Abstract: Various systems and methods for non-invasively monitoring and treating a medical condition of interest via transcutaneous stimulation of a target nerve are described. For instance, a subject can be monitored for improvement of a medical condition, where such improvement corresponds with a decrease in the threshold level at which a sensory or motor response is elicited in a subject upon stimulation as compared to a baseline level. Further, transcutaneous stimulation of the nerve can also treat the condition. Both monitoring and treatment can be carried out in a non-invasive manner substantially free of a painful response via electrical nerve stimulation of a target nerve, where the stimulation is delivered from an electrode placed on a non-glabrous skin surface. The electrode placement sufficiently immobilizes the target nerve such that the stimulation is effective and can be delivered in a controlled manner.

Abstract: A system for selectively blocking nerve fiber activity in a target nerve is provided. The system includes one or more electrodes. The system further includes an electronic control system electrically attached to each electrode to deliver electrical stimulation to a target nerve to block nerve signal transmission of C-fibers in the target nerve such that the nerve signal transmission of A-fibers in the target nerve providing motor function and/or low-threshold sensory function is not blocked. A method of delivering electrical stimulation to selectively block nerve fiber activity in a target nerve and a kit for performing a procedure to selectively block nerve fiber activity are disclosed.

Abstract: A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.