Patents by Inventor Eric Abel
Eric Abel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100361Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: August 24, 2023Publication date: March 28, 2024Applicant: Varian Medical Systems, Inc.Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
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Publication number: 20240075314Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: November 1, 2023Publication date: March 7, 2024Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AG, Varian Medical Systems Particle Therapy GmbHInventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Patent number: 11865361Abstract: Embodiments of the present invention provide methods and systems for proton therapy planning that maximize the dose rate for different target sizes for FLASH therapy treatment are disclosed herein according to embodiments of the present invention. According to embodiments, non-standard scanning patterns can be generated, for example, using a TPS optimizer, to maximize dose rate and the overall FLASH effect for specific volumes at risk. The novel scanning patterns can include scanning subfields of a field that are scanned independently or spiral-shaped patterns, for example. In general, spot locations and beam paths between spots are optimized to substantially achieve a desired dose rate in defined regions of the patient's body for FLASH therapy treatment.Type: GrantFiled: April 3, 2020Date of Patent: January 9, 2024Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG, SIEMENS HEALTHINEERS INTERNATIONAL AGInventors: Jessica Perez, Eric Abel, Michael Folkerts, Christel Smith, Adam Harrington, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Michiko Rossi
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Patent number: 11865364Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: December 22, 2022Date of Patent: January 9, 2024Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GmbH, Siemens Healthineers International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
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Publication number: 20230381537Abstract: Radiation treatment planning includes determining a number of beams to be directed into a target, determining directions (e.g., gantry angles) for the beams, and determining an energy level for each of the beams. The number of beams, the directions of the beams, and the energy levels are determined such that the beams do not overlap outside the target and the prescribed dose will be delivered across the entire target.Type: ApplicationFiled: July 28, 2023Publication date: November 30, 2023Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AGInventors: Reynald VANDERSTRATEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Josh STAR-LACK
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Patent number: 11771920Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: GrantFiled: September 27, 2021Date of Patent: October 3, 2023Assignee: Varian Medical Systems, Inc.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
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Patent number: 11766574Abstract: Radiation treatment planning includes determining a number of beams to be directed into a target, determining directions (e.g., gantry angles) for the beams, and determining an energy level for each of the beams. The number of beams, the directions of the beams, and the energy levels are determined such that the beams do not overlap outside the target and the prescribed dose will be delivered across the entire target.Type: GrantFiled: January 31, 2020Date of Patent: September 26, 2023Assignees: VARIAN MEDICAL SYSTEMS, INC., SIEMENS HEALTHINEERS INTERNATIONAL AGInventors: Reynald Vanderstraten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Josh Star-Lack
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Publication number: 20230271030Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: May 5, 2023Publication date: August 31, 2023Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AGInventors: Reynald VANDERSTRAETEN VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
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Patent number: 11712579Abstract: A system for treating a patient during radiation therapy includes range compensators. Each of the range compensators shapes a distribution of a dose delivered to the patient by a beam emitted from a nozzle of a radiation treatment system. A positioning component holds the range compensator in place relative to the patient such that the range compensator lies on a path of the beam.Type: GrantFiled: July 21, 2017Date of Patent: August 1, 2023Assignee: VARIAN MEDICAL SYSTEMS, INC.Inventors: Eric Abel, Corey Zankowski
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Publication number: 20230211178Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: December 22, 2022Publication date: July 6, 2023Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Publication number: 20230201630Abstract: Dose analysis radiotherapy systems and methods for determine delivered radiotherapy dose, dose rate, irradiation time and position information and planned radiotherapy dose, dose rate, irradiation time and position information. The dose analysis systems and methods further compare the as delivered dose, dose rate, irradiation time and position information to the planned dose, dose rate, irradiation time and position information to generate a graphical representation of one or more of the delivered dose, dose rate, irradiation time and position information versus planned dose, dose rate, irradiation time and position information.Type: ApplicationFiled: December 28, 2021Publication date: June 29, 2023Inventors: Sylvie SPIESSENS, Michael FOLKERTS, Eric ABEL, Isabel HUTH, Tina PFEILER, Pierre LANSONNEUR
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Publication number: 20230191154Abstract: A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.Type: ApplicationFiled: February 14, 2023Publication date: June 22, 2023Inventors: Eric ABEL, Corey ZANKOWSKI, Jessica PEREZ, Anthony MAGLIARI, Christel SMITH, MIchael FOLKERTS, Bill HANSEN, Reynald VANDERSTRAETEN, Timo KOPONEN
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Patent number: 11673003Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: GrantFiled: November 6, 2020Date of Patent: June 13, 2023Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS INTERNATIONAL AGInventors: Reynald Vanderstraeten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
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Publication number: 20230125147Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: ApplicationFiled: December 23, 2022Publication date: April 27, 2023Inventors: Deepak KHUNTIA, Edward VERTATSCHITSCH, Eric ABEL, Anthony MAGLIARI, Christel SMITH
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Patent number: 11590364Abstract: A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.Type: GrantFiled: June 10, 2019Date of Patent: February 28, 2023Assignees: Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GmbH & Co. KG, Varian Medical Systems, Inc.Inventors: Eric Abel, Corey Zankowski, Jessica Perez, Anthony Magliari, Christel Smith, Michael Folkerts, Bill Hansen, Reynald Vanderstraeten, Timo Koponen
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Patent number: 11554271Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: January 12, 2021Date of Patent: January 17, 2023Assignees: Varian Medical Systems, Inc, Varian Medical Systems Particle Therapy GMBH & Co. KG, Varian Medical Systems International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
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Patent number: 11541252Abstract: The dose rate of voxels within a particle beam (e.g., proton beam) treatment field delivered using pencil beam scanning (PBS) is calculated, and a representative dose rate for the particle beam treatment field is reported. The calculations account for a dose accumulation in a local region or a sub-volume (e.g., a voxel) as a function of time.Type: GrantFiled: June 23, 2020Date of Patent: January 3, 2023Assignee: Varian Medical Systems, Inc.Inventors: Michael Folkerts, Eric Abel, Simon Busold, Jessica Perez, Vidhya Krishnamurthi, C. Clifton Ling
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Patent number: 11534625Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: GrantFiled: September 24, 2020Date of Patent: December 27, 2022Assignee: Varian Medical Systems, Inc.Inventors: Deepak Khuntia, Edward Vertatschitsch, Eric Abel, Anthony Magliari, Christel Smith
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Publication number: 20220176158Abstract: Information that describes a target inside a patient to be treated with radiation is accessed from computer system memory. An arrangement of spots inside the target is determined. Each the spots corresponds to a location inside the target where a respective beam of radiation is to be directed during radiation treatment of the patient. A dose rate for each of the beams is determined. The dose rate for each beam is a dose delivered in less than one second to a spot corresponding to that beam. For example, each beam can deliver at least four grays (GY) in less than one second, and may deliver as much as 20 Gy to 50 Gy or 100 Gy or more in less than one second. A radiation treatment plan, that includes the arrangement of the spots and the dose rate for each of the beams, is stored in computer system memory.Type: ApplicationFiled: February 25, 2022Publication date: June 9, 2022Inventors: Eric ABEL, Alexander KATSIS
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Publication number: 20220176159Abstract: Information that describes a target inside a patient to be treated with radiation is accessed from computer system memory. An arrangement of spots inside the target is determined. Each the spots corresponds to a location inside the target where a respective beam of radiation is to be directed during radiation treatment of the patient. A dose rate for each of the beams is determined. The dose rate for each beam is a dose delivered in less than one second to a spot corresponding to that beam. For example, each beam can deliver at least four grays (GY) in less than one second, and may deliver as much as 20 Gy to 50 Gy or 100 Gy or more in less than one second. A radiation treatment plan, that includes the arrangement of the spots and the dose rate for each of the beams, is stored in computer system memory.Type: ApplicationFiled: February 25, 2022Publication date: June 9, 2022Inventors: Eric ABEL, Alexander KATSIS