Patents by Inventor Eric B. Shain
Eric B. Shain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20090314802Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.Type: ApplicationFiled: June 17, 2009Publication date: December 24, 2009Applicant: ABBOTT LABORATORIESInventors: Scott Safar, Stephen L. Herchenbach, Chadwick M. Dunn, Charles Michael Galitz, Julius J. Toth, Ronald E. Kukla, Michael G. Lowery, Eric B. Shain
-
Publication number: 20090252652Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.Type: ApplicationFiled: June 17, 2009Publication date: October 8, 2009Applicant: ABBOTT LABORATORIESInventors: Scott Safar, Stephen Herchenbach, Chadwick M. Dunn, Charles Michael Galitz, Julius J. Toth, Ronald E. Kukla, Michael G. Lowery, Eric B. Shain
-
Publication number: 20090246777Abstract: In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree of amplification of each target nucleic acid in the amplification reaction and the time point in the amplification reaction at which the amplitude is measured; determining an efficiency related transform of the data, determining an efficiency related value for each target nucleic acid that is the maximum magnitude of the efficiency related transform; and outputting the efficiency related values in the amplification reaction for each target nucleic acid, where the relative amplitudes of the efficiency related values for each target nucleic acid is an indicator of the presence of each of said nucleic acids in said sample.Type: ApplicationFiled: December 23, 2008Publication date: October 1, 2009Applicant: ABBOTT LABORATORIESInventor: Eric B Shain
-
Patent number: 7565250Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: GrantFiled: November 17, 2004Date of Patent: July 21, 2009Assignee: Abbott Laboratories Inc.Inventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
-
Publication number: 20090047679Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: February 19, 2009Applicant: Abbott LaboratoriesInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
-
Publication number: 20080299583Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.Type: ApplicationFiled: August 11, 2008Publication date: December 4, 2008Applicant: ABBOTT LABORATORIESInventors: Eric B. Shain, John M. Clemens, Tzyy-Wen Jeng, George J. Schneider
-
Patent number: 7303922Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: April 22, 2004Date of Patent: December 4, 2007Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 7254425Abstract: A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelengths, at different distances between the light introduction site(s) and the light collection site(s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts.Type: GrantFiled: January 23, 2004Date of Patent: August 7, 2007Assignee: Abbott LaboratoriesInventors: Michael G. Lowery, Eric B. Shain, Omar S. Khalil
-
Patent number: 7167734Abstract: A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserted into a mathematical relationship, e.g., an algorithm, that can be used to predict a disease state (such as the diabetes mellitus disease state) or the concentration of an analyte for indicating a physical condition (such as blood glucose level). This invention can be used to differentiate between disease status, such as, for example, diabetic and non-diabetic. The method involves the generation of a calibration (or training) set that utilizes the relationship between optical signals emanating from the skin under different thermal stimuli and disease status, e.g., diabetic status, established clinically. This calibration set can be used to predict the disease state of other subjects.Type: GrantFiled: April 13, 2001Date of Patent: January 23, 2007Assignee: Abbott LaboratoriesInventors: Omar S. Khalil, Shu-jen Yeh, Stanislaw Kantor, Charles F. Hanna, Eric B. Shain
-
Patent number: 6837858Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained, (b) forming a seal between said blood collection device and said surface of the skin, (c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood, (d) triggering a lancing assembly and causing a lancet to penetrate said skin, (e) retracting said lancet, (f) withdrawing blood toward and onto a fluid collector, and (g) releasing the vacuum. In another aspect of the invention, an apparatus for carrying out the method described previously is provided.Type: GrantFiled: October 5, 2001Date of Patent: January 4, 2005Assignee: Abbott LaboratoriesInventors: David D. Cunningham, Timothy P. Henning, Eric B. Shain, Douglas F. Young, Andrew J. Muetterties, Thomas G. Schapira, Geoffrey R. Chambers, Graham J. Hughes, Jared L. Watkin, Gary F. Prokop, Joshua P. Goldfarb
-
Publication number: 20040197927Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: ApplicationFiled: April 22, 2004Publication date: October 7, 2004Inventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 6773922Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: July 9, 2002Date of Patent: August 10, 2004Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 6569157Abstract: The invention involves a method for focusing light comprising the steps of: projecting at least one pulse of light onto the surface of the skin of a patient; collecting at least a portion of the light that is reflected from the skin of the patient; projecting the collected, reflected light onto a detector; and adjusting the projection of the pulsed light onto the surface of the skin of the patient in such a manner that the signal projected onto the detector is optimized. When the light pulse is properly focused, e.g., when it is characterized by the best focus, it can be used to provide energy to form an opening in the skin of the patient. When more than one pulse of light is required to form an opening in the skin of the patient, aligning the light prior to each pulse will improve the efficiency of formation of the opening.Type: GrantFiled: May 18, 1998Date of Patent: May 27, 2003Assignee: Abbott LaboratoriesInventors: Eric B. Shain, Mark R. Pope, Joseph L. Pezzaniti
-
Publication number: 20030048432Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: ApplicationFiled: July 9, 2002Publication date: March 13, 2003Inventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Publication number: 20030023151Abstract: A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserted into a mathematical relationship, e.g., an algorithm, that can be used to predict a disease state (such as the diabetes mellitus disease state) or the concentration of an analyte for indicating a physical condition (such as blood glucose level). This invention can be used to differentiate between to disease status, such as, for example, diabetic and non-diabetic. The method involves the generation of a calibration (or training) set that utilizes the relationship between optical signals emanating from the skin under different thermal stimuli and disease status, e.g., diabetic status, established clinically. This calibration set can be used to predict the disease state of other subjects.Type: ApplicationFiled: April 13, 2001Publication date: January 30, 2003Inventors: Omar S. Khalil, Shu-jen Yeh, Stanislaw Kantor, Charles F. Hanna, Eric B. Shain
-
Publication number: 20020169393Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring.Type: ApplicationFiled: October 5, 2001Publication date: November 14, 2002Inventors: David D. Cunningham, Timothy P. Henning, Eric B. Shain, Douglas F. Young
-
Patent number: 6426045Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: September 28, 1999Date of Patent: July 30, 2002Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 6365109Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: September 28, 1999Date of Patent: April 2, 2002Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 6312888Abstract: An article and a method for monitoring the concentration of an analyte, e. g., glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one embodiment, the article comprises: a multiple-layer element comprising: (a) a base layer (b) a cover layer, the cover layer having a first opening for venting the multiple-layer element and a second opening for receiving a biological sample; and (c) a core layer having a first major surface and a second major surface, the core layer disposed between the base layer and the cover layer, the core layer comprising a sample introduction chamber and a optical reading chamber, the first major surface of the core layer in face-to-face contact with the base layer, the second major surface of the core layer in face-to-face contact with the cover layer.Type: GrantFiled: October 16, 2000Date of Patent: November 6, 2001Assignee: Abbott LaboratoriesInventors: Sie Ting Wong, Robert G. Hiltibran, Tung-Ming Huang, Brenda B. Calfin, Mark R. Pope, Thomas G. Schapira, Eric B. Shain, Douglas F. Young
-
Patent number: 6306104Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained, (b) forming a seal between said blood collection device and said surface of the skin, (c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood, (d) triggering a lancing assembly and causing a lancet to penetrate said skin, (e) retracting said lancet, (f) withdrawing blood toward and onto a fluid collector, and (g) releasing the vacuum. In another aspect of the invention, an apparatus for carrying out the method described previously is provided.Type: GrantFiled: July 10, 2000Date of Patent: October 23, 2001Assignee: Abbott LaboratoriesInventors: David D. Cunningham, Timothy P. Henning, Eric B. Shain, Douglas F. Young, Andrew J. Muetterties, Thomas G. Schapira, Geoffrey R. Chambers, Graham J. Hughes, Jared L. Watkin, Gary F. Prokop, Joshua P. Goldfarb