Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: Aspects of the subject disclosure may include, for example, receiving avatar definition information from a user, the avatar definition information defining aspects of a user avatar to represent the user in an immersive experience in a first metaverse; activating the user avatar in the first metaverse, the user avatar defined according to the avatar definition information; and activating the user avatar in a second metaverse, the user avatar representing the user in the second metaverse, the user avatar defined in the second metaverse according to the avatar definition information, the activating the user avatar in the second metaverse being responsive to a request from the user to change from the first metaverse to the second metaverse. Other embodiments are disclosed.

Abstract: Synchronized satellite communications can include receiving, at a computer having a processor, a data request that identifies a requesting device, data to be received by the requesting device, and a time at which the data is to be received by the requesting device. The processor can determine a geographic location of the requesting device and locations of a plurality of satellites; identify, based on the geographic location of the requesting device and the locations of the plurality of satellites, satellites that are to provide the data to the requesting device; generate instructions for loading network requirements to the satellites; and provide, to at least one of the satellites, the instructions. Additionally, embodiments of the concepts and technologies disclosed herein can be used to provide the same data and/or different data to multiple devices at the same time.

Abstract: A system and method for slowing the rotation of a rotor using, for example, rotor brake system for a rotorcraft comprises: one or more generators connected to a main rotor gearbox; an electric distributed anti-torque system mounted on a tail boom of the rotorcraft comprising two or more electric motors connected to the one or more generators, wherein the two or more electric motors are connected to one or more blades; and wherein a rotation of the rotor is slowed by placing a drive load on the main rotor gearbox with the one or more generators to bleed the mechanical power from rotor into electrical power via the two or more electric motors, wherein the electric distributed anti-torque system generates thrust in opposing directions.

Abstract: The disclosed computer-implemented methods and systems provide solutions for mitigating misdetection of display devices in connection with a subscription service. In some examples, the described methods and systems receive a content request from a display device, where the content request is correlated with a particular subscription service account. In some examples, the systems and methods further determine that the display device is not associated with the particular subscription service account. To verify the display device, the systems and methods utilize display timings and scan timings associated with a verification token to prove that the display device is validly located and can therefore be trusted in connection with the subscription service account. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Provided are novel anti-av?6 antibodies and antibody-drug conjugates and methods of using such anti-av?6 antibodies and antibody-drug conjugates to treat cancer.

Abstract: The disclosed technology is directed towards virtual reality collaboration spaces with associated context data. Once created, a virtual reality collaboration space can be pervasively existent, such that the space can be joined or returned to as needed by any admitted participants. The existence of a created collaboration space in association with its collaboration context data can be advertised to specific invitees or general invitees, and can be searchable. In general, upon receiving a reservation request for reservation of a virtual reality collaboration space, a virtual location for the collaboration space is reserved. Access is granted to requesting entities authorized to access the space. Permissions can differ for different invitees, e.g., such that only permitted users can access proprietary information presented as a virtual reality element within the collaboration space. The collaboration space can also be used to drop off virtual reality elements, e.g., from one user to another user.

Abstract: The disclosed technology relates to detection of attention exhibited by a second user to a first user's avatar in a virtual reality environment. A first user's avatar activity and the second user's activity are evaluated to determine the second user's (e.g., via another avatar) attention level directed towards first user's avatar. Information can be sent to notify the first user that the second user's attention level has satisfied attention-level criterion data. For example, if the second user is viewing and/or is within audio range of the first user for too long of a time or too frequently, then the first user can be notified and/or other action taken. Remedial action is available for negative attention, such blocking the second user from experiencing the first user in the environment. Detection of attention for positive purposes is available, such as to reward an influencer whose avatar is receiving significant attention from followers.

Abstract: The disclosed technology is directed towards virtual reality bookmarks that maintain state data for a user in a virtual reality environment, such that the user can to return to that virtual reality environment at a later time. While presenting virtual reality session content to a user, a system or the like can receive a request to pause the virtual reality session from a user. Session state data, e.g., in the form of a virtual reality bookmark, is saved based on the pause request. A later request to resume presentation of the virtual reality content results in the system accessing the virtual reality session data, which is used to present resumed virtual reality session content to the user based on the session state data. A pause request may be for an individual user or for each user participating in a session. Virtual reality bookmarks may be shared with other users.

Abstract: The disclosed technology is directed towards presenting a medical practitioner with information that assists the practitioner in communicating with a given patient. Baseline data describing a medical patient is obtained, such as from one or more previous visits. The baseline data can be compared with current data, e.g., sensed by patient biosensors and/or discerned from a current video of the patient during the visit. Historical and/or known healthy data can be used as baseline data. Interaction data representing an interaction (e.g., a conversation during a current visit) between the medical practitioner and the medical patient is determined. Based on the baseline data and the interaction data, during the interaction between the medical practitioner and the medical patient the medical practitioner can be presented with coaching data to assist the medical practitioner in communicating with the patient.

Abstract: Provided are novel anti-?v?6 antibodies and antibody-drug conjugates and methods of using such anti-?v?6 antibodies and antibody-drug conjugates to treat cancer.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to systems, methods, and apparatuses relating to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: Aspects relate to a portable device that may be used to identify a critical intensity and an anaerobic work capacity of an individual. The device may utilize muscle oxygen sensor data, speed data, or power data. The device may utilize data from multiple exercise sessions, or may utilize data from a single exercise session. The device may additionally estimate a critical intensity from a previous race time input from a user.

Abstract: In one aspect, the invention relates to recycled polyethylene terephthalate compositions, fibers and articles produced therefrom, and methods for producing same. In a further aspect, the invention relates to homogenized post-consumer polyethylene terephthalate. In a further aspect, the invention relates to extruded polymer compositions, polymer mixtures, fibers, and/or Bulked Continuous Filament fibers comprising post-consumer polyethylene terephthalate. In a further aspect, the invention relates to processes for preparing recycled polyethylene terephthalate compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In one aspect, the invention relates to recycled polyethylene terephthalate compositions, fibers and articles produced therefrom, and methods for producing same. In a further aspect, the invention relates to homogenized post-consumer polyethylene terephthalate. In a further aspect, the invention relates to extruded polymer compositions, polymer mixtures, fibers, and/or Bulked Continuous Filament fibers comprising post-consumer polyethylene terephthalate. In a further aspect, the invention relates to processes for preparing recycled polyethylene terephthalate compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.