Abstract: A substrate assembly includes a first substrate having a first surface and an oppositely facing second surface. Signal pathways are provided on the first surface. The signal pathways extend to first openings which extend inward from an edge of the substrate. First ground pathways are provided on the first surface. Each of the first ground pathways are positioned adjacent at least one of the signal pathways. The first ground pathways extend to second openings which extend inward from the edge of the substrate. Signal contacts are mounted to the first substrate. The signal contacts have first mounting surfaces which provide mechanical and electrical engagement with the first openings. Ground contacts are mounted to the first substrate. The ground contacts have second mounting surfaces which provide mechanical and electrical engagement with the second openings.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: The present invention relates to a monitoring method for generating a distraction indicator, including: receiving data from an implantable bone distraction device, corresponding to a mechanical vibration response of a medium comprising the implantable bone distraction device, as measured by at least one vibration sensor; computing from the received data a distraction indicator through at least the steps of: determining at least one vibration pattern of said medium from the vibration response measured by the at least one vibration sensor; analyzing the evolution of a first value of the at least one vibration pattern of said medium determined from the measured vibration response during a first period; and generating a distraction indicator as a function of the first value.

Abstract: The present invention relates to an implantable bone distraction device (1) for distracting osteotomically separated bone sections (2, 2?), said implantable distraction device (1) comprising a first block (3), a second block (3?), and an actuator (4) including means for adjusting the space between the two blocks, enabling distraction between the first bone section (2) and the second bone section (2?). The implantable bone distraction device (1) further comprises at least one vibration sensor (6) arranged in an area located between the first block (3) and the second block (3?) and oriented in order to measure a vibration response of a medium comprising the implantable bone distraction device (1).

Abstract: A device for determining features of a subject's spine, including a processing unit having: a first module configured to receive a first set of spine image data of the subject, and to compute, based on spine image data of an examined spine, at least one first output relating to a first anatomical structure of the examined spine, at least one first output including a first feature of the examined spine; a second module configured to receive a first output of the first module and a second set of spine image data of the subject, and further configured to compute, based on spine image data of the examined spine and the first output, a second output relating to a second anatomical structure of the examined spine, and including a second feature of the examined spine.

Abstract: The present disclosure provides dynamic interbody fusion devices and methods of making and using same.

Abstract: An implantable bone elongation device including an inner rod defining an internal cavity housing a rotational actuator having an output shaft connected to a lead screw disposed at the end of the inner rod and in threaded engagement with a threaded inner surface of an outer rod. Rotation of the lead screw converts rotation motion into linear motion resulting in telescopic movement of the outer rod relative to the inner rod. Rotational motion is converted into linear motion by components disposed in a parallel configuration thereby minimizing the overall length of the bone elongating device while maintaining a maximum stroke length. In various embodiments, additional components, such as electronic circuit boards, electrical power supply or battery power source, may be housed within the internal cavity formed by the inner rod.

Abstract: Systems and methods describe providing for the intelligent assessment and analysis of medical patient data. In one embodiment, the system receives medical imaging data of a patient, as well as connected implant data from an implant device implanted in the patient. A number of features are extracted via artificial intelligence (AI) algorithms from the medical imaging data and connected implant data. One or more reports are then generated based on the extracted features. In some embodiments, the systems and methods provide for indices, features, information, and/or metrics which have clinical value, and which enable a surgeon to support his or her decisions (related to, e.g., diagnosis, prognosis, monitoring, or any other suitable subject area).

Abstract: A system for evaluating the evolution of the structure of a subject's bone, the system including an implantable medical device including an implant body intended to be attached to the bone of the subject and at least one reflector coupled to the implant body, the reflector being configured to reflect an electromagnetic signal and being embedded in a surrounding tissue of the subject when the implant body is attached to the subject's bone and a calculation module configured to compute a parameter representative of the structure of the subject's bone, wherein the parameter is computed from a reflected signal corresponding to a reflection, on the reflector embedded in the surrounding tissue of the subject, of an excitation signal including at least one frequency in the characteristic frequency range of the reflector, the reflected signal being representative of at least one electrical property of the surrounding tissue.

Abstract: A system for evaluating the evolution of a subject's bone structure, including an implantable medical device and a calculation module for computing a parameter representative of the bone structure. The implantable medical device has a distraction body and reflector(s). The distraction body distracts osteotomically separated bone section bodies and includes first/second blocks for implantation and attachment to first/second bone sections, the second bone section separated from the first bone section by an osteotomy, and an actuator for adjusting space between the first/second blocks, enabling distraction between the first/second bone sections. Each reflector reflects an electromagnetic signal and is embedded in a surrounding tissue when the distraction body is attached to the bone.

Abstract: A implantable bone distraction device for distracting osteotomically separated bone sections includes a first block, a second block, and an actuator including elements for adjusting the space between the two blocks, a vibration sensor arranged in an area located between the first block and the second block and oriented in order to measure a vibration response of a medium of the implantable bone distraction device. A medical monitoring device includes a receiver for receiving data from an implantable bone distraction device, corresponding to a mechanical vibration response of a medium; a calculator for computing from the received data a distraction indicator by: (i) determining a vibration pattern of the medium from the measured vibration response; (ii) analyzing the evolution of a value of the vibration pattern from the measured vibration response during a first period; and (iii) generating a distraction indicator when the value exceeds a predefined threshold.

Abstract: A method of communication between a remote action manager and a communication box, for interacting with equipment connected to the communication box, by creating an association of a communication mechanism with the box, receiving an action request at the action manager destined for the equipment, identifying the communication mechanism associated with the box, and communicating the action request to the box via the identified communication mechanism.

Abstract: Disclosed is an invasive intervertebral fusion cage, the intervertebral fusion cage including: a vibration sensor; and a frame configured to support surrounding tissues used to create a bone fusion process; wherein the vibration sensor is integral with the frame in order to measure the mechanical vibrations the vibrations arising from the medium consisting of the frame, the surrounding tissues and/or the fusionned bone, and wherein the intervertebral fusion cage does not include a vibration excitation transducer. Also disclosed is a remote medical monitoring device including a receiver for receiving data from an intervertebral fusion cage, reflecting the mechanical vibrations of a medium and a calculator computing from the received data a medium indicator by: determining at least one vibration pattern of the received data; comparing the at least one vibration pattern with at least one reference model; generating a medium indicator in function of the comparing step.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.

Abstract: The present disclosure provides implantable bone distraction devices and methods of using same to elongate a bone.

Abstract: Method of communication between a remote action manager (14) and a communication box (5) for interacting with a device (1) connected to said communication box (5), this box (5) and this device (1) being included in a local network, the box (5) being connected to said remote action manager (14) by way of an integrated access apparatus (25) having a public address, this method comprising the following steps—association of a communication mechanism with said box (5), this association being stored in a database (15) associated with said action manager (14); —reception, by the action manager (14), of a request (16) for action destined for said device; —identification, in said database (15), of the communication mechanism associated with said box (5); —communication of the request (16) for action to said communication box (5) via the identified communication mechanism.

Abstract: The present invention relates to an implantable bone distraction device (1) for distracting osteotomically separated bone sections (2, 2?), said implantable distraction device (1) comprising a first block (3), a second block (3?), and an actuator (4) including means for adjusting the space between the two blocks, enabling distraction between the first bone section (2) and the second bone section (2?). The implantable bone distraction device (1) further comprises at least one vibration sensor (6) arranged in an area located between the first block (3) and the second block (3?) and oriented in order to measure a vibration response of a medium comprising the implantable bone distraction device (1).

Abstract: The present invention relates to a system for evaluating the evolution of the structure of a bone of a subject, said system comprising an implantable medical device comprising a distraction body and at least one reflector coupled to the distraction body, said distraction body being configured to distract osteotomically separated bone section bodies and comprising a first block for implantation and attachment to a first bone section, a second block for implantation and attachment to a second bone section separated from the first bone section by an osteotomy, an actuator configured to adjust the space between the first block and the second block when activated, enabling distraction between the first bone section and the second bone section, wherein said at least one reflector is configured to reflect an electromagnetic signal and is embedded in a surrounding tissue of the subject when the distraction body is attached to the bone of the subject, a calculation module configured to compute a parameter representati

Abstract: Disclosed is an invasive intervertebral fusion cage, the intervertebral fusion cage including: a vibration sensor; and a frame configured to support surrounding tissues used to create a bone fusion process; wherein the vibration sensor is integral with the frame in order to measure the mechanical vibrations the vibrations arising from the medium consisting of the frame, the surrounding tissues and/or the fusionned bone, and wherein the intervertebral fusion cage does not include a vibration excitation transducer. Also disclosed is a remote medical monitoring device including a receiver for receiving data from an intervertebral fusion cage, reflecting the mechanical vibrations of a medium and a calculator computing from the received data a medium indicator by: determining at least one vibration pattern of the received data; comparing the at least one vibration pattern with at least one reference model; generating a medium indicator in function of the comparing step.