Abstract: In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.

Abstract: A system for actuating an engine valve to decompress an engine cylinder for engine start up and/or engine braking is disclosed. The system may include a first member, such as an outer piston, disposed above an engine valve, which receives an inner piston extending into a bore provided in the first member. One or more springs may bias the inner piston into a predefined position in the first member. The inner piston may include a lower surface that directly, or through an intervening sliding pin, actuates an engine valve in response to the application of fluid pressure on the inner piston. The inner piston may be used to decompress an engine cylinder for engine start up and/or to provide engine braking.

Abstract: The present disclosure provides an overhead console for a motor vehicle that can firmly hold, store and allow viewing of a portable electronic device. The overhead console can include a sunglass storage bin that is pivotally attached to an overhead console storage structure, the sunglass storage bin having a closed position and an open position. The console can also include a storage unit insert that is attached to and located at least partially within the sunglass storage bin. The storage unit insert can be dimensioned to hold a portable electronic device within the sunglass storage bin and allow the device to be stored out of view when the sunglass storage bin is in the closed position and allow viewing of the electronic device when the sunglass storage bin is in the open position.

Abstract: The present disclosure provides an overhead console for a motor vehicle that can firmly hold, store and allow viewing of a portable electronic device. The overhead console can include a sunglass storage bin that is pivotally attached to an overhead console storage structure, the sunglass storage bin having a closed position and an open position. The console can also include a storage unit insert that is attached to and located at least partially within the sunglass storage bin. The storage unit insert can be dimensioned to hold a portable electronic device within the sunglass storage bin and allow the device to be stored out of view when the sunglass storage bin is in the closed position and allow viewing of the electronic device when the sunglass storage bin is in the open position.

Abstract: A system for actuating an engine valve to decompress an engine cylinder for engine start up and/or engine braking is disclosed. The system may include a first member, such as an outer piston, disposed above an engine valve, which receives an inner piston extending into a bore provided in the first member. One or more springs may bias the inner piston into a predefined position in the first member. The inner piston may include a lower surface that directly, or through an intervening sliding pin, actuates an engine valve in response to the application of fluid pressure on the inner piston. The inner piston may be used to decompress an engine cylinder for engine start up and/or to provide engine braking.

Abstract: The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LT?R signaling are also provided.

Abstract: Disclosed herein is a system comprising a reciprocating water gas shift reactor; the water gas shift reactor being operative at speeds down to about 1 revolution per minute, while converting carbon monoxide (CO) and steam (H2O) into carbon dioxide (CO2) and hydrogen (H2). Disclosed herein too is a system comprising a hydrogen engine, or fuel cell with electric motor, and a water gas shift reactor; the hydrogen engine, or fuel cell with electric motor being in operative to drive the water gas shift reactor at speeds down to about 1 revolution per minute; and operative to convert carbon monoxide (CO) and steam (H2O), into carbon dioxide (CO2) and hydrogen (H2).

Abstract: Disclosed herein is system comprising a system comprising a high temperature gasifier; the high temperature gasifier being operative to function at temperatures of greater than or equal to about 450° F.; and a synthesizing reactor in fluid communication with the high temperature gasifier; the synthesizing reactor being operative to convert carbon dioxide into another form of carbon. Disclosed herein too a method comprising gasifying a waste stream to produce a composition that comprises syngas; the syngas comprising carbon monoxide and hydrogen; the gasifying being conducted in a high temperature gasifier; the high temperature gasifier being operative to function at temperatures of greater than or equal to about 450° F.; converting the carbon monoxide into carbon dioxide; and feeding the carbon dioxide to an synthesizing reactor to produce an oil rich algae.

Abstract: The system, based on a recirculating Carbon Flow Loop, neutralizes toxins within municipal waste or other feedstock. A Plasma Syngas Gasifier is used to generate ultra high temperatures in an oxygen controlled atmosphere. This breaks down the feedstock into its basic elements, predominantly hydrogen and carbon monoxide, known as syngas. This can be used as a fuel, and/or be processed using water shift reaction, to yield additional hydrogen plus carbon dioxide. Following processing the carbon dioxide gas flow continues in the Carbon Flow Loop to an Algae Bioreactor. Here photosynthesis transforms it into oil rich algae. This can continue in the Carbon Flow Loop as feedstock for the Plasma Syngas Gasifier, and/or exit the loop, and be used to manufacture biofuels or other products. New feedstock is added to the Carbon Flow Loop to replace carbon lost or removed.

Abstract: The system, based on an enclosed recirculating Carbon Flow Loop, uses plasma to neutralizes toxins within municipal waste or other feedstock. This breaks down the feedstock into its basic elements, predominantly hydrogen and carbon monoxide, known as syngas. The syngas is further processed using combustion, to transform the carbon monoxide into carbon dioxide. The carbon dioxide gas flow continues in the Carbon Flow Loop to an Algae Bioreactor. Here photosynthesis of algae transforms the carbon dioxide into an oil rich carbohydrate. This can either continue in the Carbon Flow Loop as feedstock, and/or exit the loop, and be used to manufacture biofuels or other products. New feedstock is added to the system to replace removed carbon.

Abstract: The system is based on a recirculating Carbon Flow Loop, within which toxins in municipal waste or other feedstock are neutralized in a plasma reactor, by using an electric arc in ionized gas to generate ultra high temperatures. This breaks down substances into their basic molecules, and transforms the feedstock into syngas (which is comprised predominantly of hydrogen and carbon monoxide). This can be processed by a water shift reactor, an engine driven electric generator or another exothermic device where carbon monoxide is transformed into carbon dioxide. This continues flowing in the carbon loop to an Algae Bioreactor. Here photosynthesis of the algae transforms the carbon dioxide to become part of an oil rich carbohydrate. This can either continue to the next stage as feedstock and recirculate again around the Carbon Loop and/or exit, and be used to manufacture biofuel or other substances.

Abstract: A blended composition having a polyester component, an olefin-vinylalcohol component, and an impact modifier component. The compositions of the present invention may be formed into containers and are specifically suitable for making fuel tanks.

Abstract: An apparatus for limiting the travel of a slave piston (110) in a slave piston cylinder (100) in a compression release engine brake is disclosed. The apparatus provides stroke-limiting means and independent lash adjustment means which may be installed in a common rail, variable valve actuation system. The independent lash adjustment means comprises a sleeve (300) around the slave piston (110), threadably mounted in the brake housing (40). The stroke-limiting means comprises a slave piston (110) in a slave piston cylinder (100), a trigger valve (90) and a hydraulic circuit connected thereto. The slave piston stroke is limited when a lower flow port (130) in the slave piston cylinder (100) is opened to drain (81) slightly before high-pressure flow is cut off through an upper flow port (120) in the slave piston cylinder (100).

Abstract: An actuator for moving a solenoid armature to control fuel in response to a control current is built into a fuel pump, with trapped air in and around the actuator preventing contamination of the actuator by ferromagnetic particles in the liquid fuel from the fuel pump.

Abstract: An inexpensive type of linear solenoid actuator for moving a plunger along a straight line, while providing a force on the plunger due to the actuator which does not vary greatly over the length of stroke of the plunger; a spring opposes the force exerted on the plunger by the solenoid, so that the plunger will assume any of a range of positions in response to different currents through the solenoid. The plunger has a first larger portion of magnetic material sliding in a first bearing; a tapered second magnetic portion extending forwardly from the first portion; a magnetic third portion of substantially cylindrical form extending forwardly from the tapered portion; and a front non-magnetic portion sliding in a second bearing and supporting the front end of the plunger. The second bearing is in a magnetic end piece having substantial axial width.

Abstract: First and a second rotating members are driven in syntony with each other but at variable advance angles with respect to each other. A sensor (32) provides a position signal indicative of a predetermined rotational position of the first rotating member. A toothed wheel (40) is fixed to the second rotating member and a sensor (44) adjacent to the wheel provides a pulse indicative of each occurrence of tooth (42)/sensor (44) juxtaposition. The speed of the rotating members is determined by the pulse frequency or the time interval between the pulses. The advance angle is determined by measuring the time interval between the position signal and a particular pulse, such as the one immediately after the position signal, and multiplying the result by the determined speed.

Abstract: A stepper motor (40) is used to position the pump rack (32A) via a preloaded compliant linkage (52,54,56) in a fuel injection pump (18), thereby exercising control over the end of injection event in response to various engine operating parameters. One part (52) of the compliant linkage (52,54,56) is engaged with the output shaft (46) of the stepper motor (40). The stop (96) is provided at the zero throttle position of the engaged part (52) of the linkage (52,54,56), at the exteme distal end of its positional range. A position sensor (100) is located at a predetermined reference position away from the stop (96) to provide a signal indicative of the engaged part (52) being at that position. When the stepper motor (40) is advanced to move the engaged part (52) away from the stop (96), the pulse count to the stepper motor is rereferenced when the reference position is reached.

Abstract: Information relating to relative fuel pump camshaft advance angle is compared with a SOC signal indicative of the start of combustion in a reference cylinder to generate an adaptive trim table which is used, in a first control scheme to calculate an actual combustion angle for closed loop control over combustion timing only in the event of a loss of the SOC signal. In an alternate control scheme, the values from the adaptive trim table are always used to calculate the actual combustion angle for closed loop control.

Abstract: According to the invention, the time for start of combustion in an engine cylinder is provided by disposing a sensor in the combustion chamber of the cylinder, said sensor providing a signal indicative of the amplitude/time of the combustion event within the cylinder. Two signal levels are measured, a first level which is above the noise in the signal and a second level which is below the maximum amplitude of the signal which may be attenuated by carbon buildup on the sensor. By extrapolating backwards from these two sensed levels, a reference time for start of combustion is calculated.

Abstract: The disclosure illustrates an electronically controlled fuel pump in which the microprocessor is cooled by the fuel extending to the inlet of a positive displacement pump. The cooling passage has a labyrinth flow path and the heat sinks of the microprocessor transfer heat to the passage through conduction. An auxiliary pump causes fuel to flow through the heat exchange passage during certain conditions, such as shutdown, to maintain the temperature of the microprocessor below a predetermined maximum. Transducers and other control elements associated with the microprocessor are maintained in a cavity in the fuel pump to protect them from the environment and a pivotal connection with appropriate placement of the leads is provided in the housing for ready access to these transducers and control elements.