Abstract: The present invention provides selected dihydrobenzimidazolones which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: Self-mixing interferometry (SMI) sensors can be used for generation of content using an input device without requiring a touch-sensitive surface. In some examples, the SMI sensors can be used to detect characteristics of the input device including position, orientation, and/or motion of the input device and/or force applied by the input device (e.g., force applied by a stylus tip). In some examples, some or all of the characteristics of the input device can be used in processing to generate content, including textual character input and three-dimensional objects. In some examples, the generation of content can use information from one or more additional sensors for the input device and/or from additional devices in combination with the characteristics of the input device based on the SMI sensors for generation of content.

Abstract: Two or more numerical samples are read from a storage location (or many storage locations) and the samples are compared to generate a single bit of entropy. This method is repeated to populate two arrays which are also compared to generate a single bit. Comparison of the arrays is also repeated to generate a sequence of bits which are formed into computer words. The words are combined with a shift register to generate a seed block array of any length. The seed block array is used to seed a pseudo random number generator. The storage location is a register, accumulator, buffer, clock, address, memory location, etc., that changes periodically. Comparison may be performed by counting the number of certain types of bits in the two values and returning a one or zero depending upon the count.

Abstract: Two or more numerical samples are read from a storage location (or many storage locations) and the samples are compared to generate a single bit of entropy. This method is repeated to populate two arrays which are also compared to generate a single bit. Comparison of the arrays is also repeated to generate a sequence of bits which are formed into computer words. The words are combined with a shift register to generate a seed block array of any length. The seed block array is used to seed a pseudo random number generator. The storage location is a register, accumulator, buffer, clock, address, memory location, etc., that changes periodically. Comparison may be performed by counting the number of certain types of bits in the two values and returning a one or zero depending upon the count.