Abstract: A vehicle window vent is shaped and sized to fit in the opening left when the vehicle window is lowered or retracted. The vent fits in the opening, and its edges are captured by channels that hold the window when the window is closed. Along one edge, the vent comprises a channel, similar to the window-opening channel, so that the vent can accept an edge of the window. Thus, when the window is opened and then partially closed on the vent, the window and vent together are held securely in the window opening. The vent comprises louvered openings to allow air in and out of the vehicle. The openings may be covered with screen or mesh to prevent insects from entering the vehicle. Other features may be provided as well. An efficient method for manufacturing the vents is also described and claimed.

Abstract: A vehicle window vent is shaped and sized to fit in the opening left when the vehicle window is lowered or retracted. The vent fits in the opening, and its edges are captured by channels that hold the window when the window is closed. Along one edge, the vent comprises a channel, similar to the window-opening channel, so that the vent can accept an edge of the window. Thus, when the window is opened and then partially closed on the vent, the window and vent together are held securely in the window opening. The vent comprises louvered openings to allow air in and out of the vehicle. The openings may be covered with screen or mesh to prevent insects from entering the vehicle. Other features may be provided as well. An efficient method for manufacturing the vents is also described and claimed.

Abstract: The present invention relates to a plastic preform (200) for a container (300) comprising at least one elongate reinforcing element (210), and obtained by injection-molding. The present invention further relates to a container (300) blow-molded from such a preform (200), and comprising at least one reinforcing element (320), and having a continuous and smooth outer surface (310b).

Abstract: The present invention relates to a novel crystalline ethyl acetate solvate form of cabazitaxel or 4?-acetoxy-2?-benzoyloxy-5?,20-epoxy-1?-hydroxy-7?, 10?-dimethoxy-9-oxo-11-taxen-13?-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and process for preparing the same.

Abstract: Lightweight containers having improved stability and side- and top-loading features are provided. In a general embodiment, the present disclosure provides a first body portion with ribs having a constant depth and a constant width; a second body portion connected to the first body portion and having several undulating ribs, each undulating rib having a constant depth, a constant width, and at least one bridge member located within the width of its corresponding rib; and a third body portion connected to the second body portion and having at least one rib having a constant depth and a constant width. The structural features of the present containers advantageously provide for improved compression capacity and stability when compared to similar containers currently on the market.

Abstract: The present invention relates to a novel crystalline ethyl acetate solvate form of cabazitaxel or 4?-acetoxy-2?-benzoyloxy-5?,20-epoxy-1?-hydroxy-7?,10?-dimethoxy-9-oxo-11-taxen-13?-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and process for preparing the same.

Abstract: The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.

Abstract: The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Abstract: The present invention relates to a novel crystalline ethyl acetate solvate form of cabazitaxel or 4?-acetoxy-2?-benzoyloxy-5?,20-epoxy-1?-hydroxy-7?,10?-dimethoxy-9-oxo-11-taxen-13?-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and process for preparing the same.

Abstract: The present invention relates to a plastic preform (1) for a container comprising at least one elongate protrusion (10, 12, 13, 14, 15) and/or groove (20), which is obtained by injection molding. The present invention further relates to a container blow-molded from such a preform comprising at least one longitudinal protrusion (32, 33, 34) and/or groove and having a continuous inner and outer surface.

Abstract: The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Abstract: The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.

Abstract: The present invention relates to a plastic preform (200) for a container (300) comprising at least one elongate reinforcing element (210), and obtained by injection-molding. The present invention further relates to a container (300) blow-molded from such a preform (200), and comprising at least one reinforcing element (320), and having a continuous and smooth outer surface (310b).

Abstract: The present invention relates to a plastic preform (1) for a container comprising at least one elongate protrusion (10, 12, 13, 14, 15) and/or groove (20), which is obtained by injection moulding. The present invention further relates to a container blow-moulded from such a preform comprising at least one longitudinal protrusion (32, 33, 34) and/or groove and having a continuous inner and outer surface.

Abstract: The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P3 (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P2 having formula (IV) or P?2 having formula (V) so as to respectively obtain the compound P4 or P?4, which have formulas (VI) and (VII), respectively; then, during a step for deprotection in the presence of an acid and/or a base, the compound having P4 or P?4 leads, after an optional purification step, to the compound having formula (I) or (II).

Abstract: Method of making a container having an elongated body equipped with a neck, such as a bottle (2), from a preform (1) made of thermoplastic polymer, said bottle (2) having special dimensional parameters. It essentially comprises a step of stretching and blowing a thin-walled (10) preform (1) with an average thickness (e) of its wall (10) less than 2 mm and an aspect ratio u=l/e, l being the length of the thin walled-preform (1), superior to 45.

Abstract: The disclosure relates to the solubilization of docetaxel in an organic solvent, to the mixture thereof with polysorbate 80, and to the evaporation of the solvent.

Abstract: The present invention relates to a process for manufacturing a preform from a semicrystalline amorphous polymer at a slow rate of crystallization, in which: the said polymer is plasticized at (3) by rapidly raising its temperature to a temperature below the melting point; the said plasticized polymer is pressed through a die (4); on leaving the die, the said polymer is swept by a hot dry inert gas (11); the plasticized polymer is received in a first container (6), while keeping the polymer at the same temperature as the plasticizing temperature in all the steps; and a die pressing step (13) is carried out in the said first container or in a second container, transferred from the first, with sudden cooling so as to obtain the preform in an amorphous state.