Abstract: Presented are methods of assessing the teratogenicity of agents by measuring the degradation of SALL4, and related compounds with reduced teratogenicity. Provided herein is a method for assessing the teratogenicity of an agent comprising: contacting an agent with SALL4; and measuring levels of SALL4, wherein the agent is teratogenic if SALL4 levels are substantially reduced in the presence of the agent relative to in the absence of the agent.

Abstract: DCAF15 is a substrate recognition (adaptor) protein of E3 ubiquitin ligase. Disclosed herein are compounds that recruit ubiquitin ligase CRL4DCAF15, to a target RNA recognition motif (RRM), causing its degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: A thermal battery system may be provided comprising: a vessel comprising a phase change material and a gas; a heat exchanger configured to transfer heat to and/or from the phase change material; a temperature sensor configured to detect an indication of a temperature of the gas; a pressure sensor configured to detect an indication of a pressure of the gas; and a processor configured to determine a state of charge of the thermal battery system from the indication of the pressure and the indication of the temperature of the gas.

Abstract: An electronics cabinet cooling system may include multiple cabinet heat exchangers mounted at an air discharge of respective different electronic cabinets. Heat from a flow of air heated by electronic components in the electronic cabinets may be received by respective cabinet heat exchangers. A liquid refrigerant flowing through the heat exchangers in parallel may be at least partially changed from liquid to gas and absorb the heat from the flow of air. A three-way tee in a common outlet header downstream from the cabinet heat exchangers may direct the gas refrigerant to a condenser and the liquid refrigerant to a receiver. The condenser may condense the gas refrigerant to liquid refrigerant, which may be routed to the receiver.

Abstract: A thermal battery system may be provided comprising: a vessel comprising a phase change material and a gas; a heat exchanger configured to transfer heat to and/or from the phase change material; a temperature sensor configured to detect an indication of a temperature of the gas; a pressure sensor configured to detect an indication of a pressure of the gas; and a processor configured to determine a state of charge of the thermal battery system from the indication of the pressure and the indication of the temperature of the gas.

Abstract: A heat transfer system for high transient heat loads includes a fluid, a heat exchanger; a compressor downstream of the heat exchanger outlet; a condenser downstream of the compressor outlet, and a thermal energy storage (TES) section downstream of the condenser outlet and upstream of the heat exchanger. The TES section may include a first pressure regulating valve downstream of a TES unit; and a second pressure regulating valve upstream of the first pressure regulating valve.

Abstract: A heat transfer system for high transient heat loads includes a fluid, a heat exchanger; a compressor downstream of the heat exchanger outlet; a condenser downstream of the compressor outlet, and a thermal energy storage (TES) section downstream of the condenser outlet and upstream of the heat exchanger. The TES section may include a first pressure regulating valve downstream of a TES unit; and a second pressure regulating valve upstream of the first pressure regulating valve.

Abstract: A thermal system may comprise a reservoir, a first fluid flowpath, and a second fluid flowpath. The first fluid flowpath may start at the reservoir and return to the reservoir. The first fluid flowpath may comprise, in a direction of the fluid flow, a first side of a sub-cooler, a liquid pump, a first side of a pre-heater, and a first side of an evaporator. The second fluid flowpath may start at the reservoir and return to the reservoir. The second fluid flowpath may comprise, in a direction of a fluid flow, a pressure regulator, a vapor compressor, a first side of a condenser, and an expansion value.

Abstract: A heat transfer system for high transient heat loads includes a fluid, a heat exchanger; a compressor downstream of the heat exchanger outlet; a condenser downstream of the compressor outlet, and a thermal energy storage (TES) section downstream of the condenser outlet and upstream of the heat exchanger. The TES section may include a first pressure regulating valve downstream of a TES unit; and a second pressure regulating valve upstream of the first pressure regulating valve.

Abstract: A heat transfer system for high transient heat loads includes a fluid, a heat exchanger; a compressor downstream of the heat exchanger outlet; a condenser downstream of the compressor outlet, and a thermal energy storage (TES) section downstream of the condenser outlet and upstream of the heat exchanger. The TES section may include a first pressure regulating valve downstream of a TES unit; and a second pressure regulating valve upstream of the first pressure regulating valve.

Abstract: A thermal system may comprise a reservoir, a first fluid flowpath, and a second fluid flowpath. The first fluid flowpath may start at the reservoir and return to the reservoir. The first fluid flowpath may comprise, in a direction of the fluid flow, a first side of a sub-cooler, a liquid pump, a first side of a pre-heater, and a first side of an evaporator. The second fluid flowpath may start at the reservoir and return to the reservoir. The second fluid flowpath may comprise, in a direction of a fluid flow, a pressure regulator, a vapor compressor, a first side of a condenser, and an expansion value.

Abstract: Systems and methods for suppressing infrared radiation generated by a turbine engine. A system comprises a primary assembly having a center body, a plurality of vanes extending from the center body, an outer radial duct with the plurality of vanes extending therethrough, a structural baffle, and a mixer. The primary assembly is disposed in the exhaust flow path of a turbine engine and encased in ducting and/or an airfoil. An air flow path defined between the center body and outer radial duct is axially spit by an interface rim and flow segregator. The flow segregator segregates engine core flow from ambient air flow.

Abstract: Systems and methods for suppressing infrared radiation generated by a turbine engine. A system comprises a primary assembly having a center body, a plurality of vanes extending from the center body, an outer radial duct with the plurality of vanes extending therethrough, a structural baffle, and a mixer. The primary assembly is disposed in the exhaust flow path of a turbine engine and encased in ducting and/or an airfoil. An air flow path defined between the center body and outer radial duct is axially spit by an interface rim and flow segregator. The flow segregator segregates engine core flow from ambient air flow.