Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: Error correction in ancestry classification includes obtaining, from a classifier, initial ancestry classifications associated with portions of two phased haplotypes of a chromosome pair of an individual; performing error correction on an initial ancestry classification, including detecting a phasing error in the initial ancestry classifications; and outputting a corrected ancestry classification in which the phasing error is corrected.

Abstract: A piezoelectric inertia actuator is disclosed herein, which includes an actuator body, a coupling body defining a receiver, a lock body positioned within the receiver, and a piezo body attached to the coupling body. At least one flexible frame configured to support an engaging body may extend from the piezo body. A spring blade configured to apply a preload force to the engaging body via a decoupling preload body may extend from the coupling body. A tension member may be positioned within the lock body and apply a preload force to the piezo body, thereby creating a net compressive stress therein. The piezoelectric inertia actuator may further include a piezo preload body configured to apply a reaction force to the piezo body in order to maintain the compressive stress therein. The preload applied to the piezo body may be substantially decoupled from the preload applied to the engaging body.

Abstract: A piezoelectric inertia actuator is disclosed herein, which includes an actuator body, a coupling body defining a receiver, a lock body positioned within the receiver, and a piezo body attached to the coupling body. At least one flexible frame configured to support an engaging body may extend from the piezo body. A spring blade configured to apply a preload force to the engaging body via a decoupling preload body may extend from the coupling body. A tension member may be positioned within the lock body and apply a preload force to the piezo body, thereby creating a net compressive stress therein. The piezoelectric inertia actuator may further include a piezo preload body configured to apply a reaction force to the piezo body in order to maintain the compressive stress therein. The preload applied to the piezo body may be substantially decoupled from the preload applied to the engaging body.

Abstract: Ancestry deconvolution includes obtaining unphased genotype data of an individual; phasing, using one or more processors, the unphased genotype data to generate phased haplotype data; using a learning machine to classify portions of the phased haplotype data as corresponding to specific ancestries respectively and generate initial classification results; and correcting errors in the initial classification results to generate modified classification results.

Abstract: According to an aspect, a helmet system includes a communication interface configured to receive a plurality of aircraft data, a memory system configured to store the aircraft data, and a processing system operably coupled to the communication interface and the memory system. The processing system is configured to format the aircraft data into a plurality of time sequential records, store the time sequential records in the memory system, and manage storage within the memory system as a circular buffer.

Abstract: A camera assembly is provided for a facial recognition system of a motor vehicle. The camera assembly includes a cosmetic panel adapted to be attached to the motor vehicle. The cosmetic panel has an outboard side and an inboard side facing the motor vehicle. The cosmetic panel is opaque to visible light and transmissive to an infrared light. The camera assembly further includes a single infrared camera adapted to be disposed adjacent to the inboard side of the cosmetic panel. The single infrared camera generates an image signal, in response to the single infrared camera receiving the infrared light transmitted through cosmetic panel.

Abstract: A piezoelectric inertia actuator is disclosed herein, which includes an actuator body, a coupling body defining a receiver, a lock body positioned within the receiver, and a piezo body attached to the coupling body. At least one flexible frame configured to support an engaging body may extend from the piezo body. A spring blade configured to apply a preload force to the engaging body via a decoupling preload body may extend from the coupling body. A tension member may be positioned within the lock body and apply a preload force to the piezo body, thereby creating a net compressive stress therein. The piezoelectric inertia actuator may further include a piezo preload body configured to apply a reaction force to the piezo body in order to maintain the compressive stress therein. The preload applied to the piezo body may be substantially decoupled from the preload applied to the engaging body.

Abstract: The present application discloses a multi-axis motion system and methods of use, using an air bearing configured to position a semiconductor wafer chuck support relative to an inspection device. The air bearing includes a vacuum clamping function operative to secure the wafer chuck support to a surface formed on the underside of a structure that houses the inspection device. In one embodiment, the system includes a first positioner operative to position a carriage assembly in a first direction, the carriage assembly including a second positioner and a third positioner operative to selectively and independently travel in a second direction orthogonal to the first direction. The chuck support is secured to the positioners by one or more pivoting decoupling systems configured to transmit actuation forces from the positioners in the first and second directions, allowing the chuck support to be decoupled from the positioners when the chuck support is vacuum clamped to the underside of the structure.

Abstract: According to an aspect, a helmet system includes a communication interface configured to receive a plurality of aircraft data, a memory system configured to store the aircraft data, and a processing system operably coupled to the communication interface and the memory system. The processing system is configured to format the aircraft data into a plurality of time sequential records, store the time sequential records in the memory system, and manage storage within the memory system as a circular buffer.

Abstract: A method for compensating for accuracy errors of a hexapod is disclosed, said hexapod comprising a base, an actuation assembly having six linear translation actuators, a control unit, and a movable carriage comprising a platform connected to the base by means of the actuation assembly. The method includes a measurement step for determining geometry and positioning errors on the hexapod, the measurement step including sub-steps for determining positioning errors of the pivot centers on the carriage and on the base, for determining length errors of the actuators and for measuring positioning errors of the actuators along the path thereof, the compensation method also including a step for calculating, from measurements taken, error compensation values and a step for applying said error compensation values to the control unit of the hexapod, during subsequent use of said hexapod.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: The invention relates to a system (1) for moving a support plate (2), the support plate (2) being, in a so-called neutral position, substantially parallel to an XY plane defined by a so-called X direction and a so-called Y direction, said system comprising at least two control stages (E1, E2) which are superimposed in a direction Z orthogonal to said X and Y directions, the two control stages (E1, E2) being secured to each other, at least one of said control stages (E1, E2) comprising a control module (M1, M2), the control module (M1, M2) comprising only movement units designed so as to each generate a translational movement in an XY plane, respectively in different directions.

Abstract: A Pockels cell that includes two similar electro-optical crystals oriented to achieve temperature compensation on a horizontal metal base common to the two crystals, and a carrier structure. It includes, between the base and the carrier structure, a thermally conductive element, which has a configuration that is symmetric about a vertical plane passing between the two crystals, in order to symmetrically distribute, to the base, a heat flux generated in the carrier structure asymmetrically with respect to the vertical plane.

Abstract: A machine having a work implement includes a sensor connected to the work implement, the sensor providing a signal indicative of a change in acceleration of the work implement. A cycle controller associated with the sensor, the cycle controller disposed to receive the signal and operating to monitor the signal. The cycle controller is programmed and operates to analyze the signal to determine at least a presence and a duration of a change in acceleration of the work implement of the machine with respect to time, compile an actual time trace of the change in acceleration of the work implement, compare the actual time trace with a predefined time trace that represents a work cycle segment, and catalog presence and duration of a work cycle segment when the actual time trace is consistent with the predefined time trace.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: Error correction in ancestry classification includes obtaining, from a classifier, initial ancestry classifications associated with portions of two phased haplotypes of a chromosome pair of an individual; performing error correction on an initial ancestry classification, including detecting a phasing error in the initial ancestry classifications; and outputting a corrected ancestry classification in which the phasing error is corrected.

Abstract: The invention relates to a system (1) for moving a support plate (2), the support plate (2) being, in a so-called neutral position, substantially parallel to an XY plane defined by a so-called X direction and a so-called Y direction, said the system comprising at least two control stages (E1, E2) which are superimposed in a direction Z orthogonal to said the X and Y directions, the two control stages (E1, E2) being secured to each other, at least one of said the control stages (E1, E2) comprising a control module (M1, M2), the control module (M1, M2) comprising only movement units designed so as to each generate a translational movement in an XY plane, respectively in different directions.