Abstract: Disclosed herein are protein-targeting chimeric molecules (PROTACs) that recruit a specific ubiquitin ligase, such as LRL4DCAF15, to a chosen target protein, causing its degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: DCAF15 is a substrate recognition (adaptor) protein of E3 ubiquitin ligase. Disclosed herein are compounds that recruit ubiquitin ligase CRL4DCAF15, to a target RNA recognition motif (RRM), causing its degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: A method for generating a dimerization and/or degradation moiety for a first protein and a second protein, where the method includes (a) generating, in silico a set of poses by docking a first protein, and a second protein, (b) generating a subset of poses by selecting one or more poses from the set of poses based on the scores of the poses, (c) identifying a candidate pose from the subset of poses based on the spatial relationship between the two proteins, (d) designing a linker between the first ligand and the second ligand that accommodates the candidate pose, and (e) synthesizing or having synthesized the dimerization and/or degradation moiety having the first ligand, the second ligand, and the linker.

Abstract: An adjusting device is proposed for adjusting a first component and a second component of a passenger or freight transport vehicle relative to each other, wherein the two components are arranged adjacent to each other to form a gap. The device includes a base body, an adjusting element mounted in the base body and movable along a first axis and an actuating body mounted in the base body and movable along a second axis which cooperates with the adjusting element such that the movement of the adjusting element along the first axis converted into a movement of the actuating body and/or the adjusting element along the second axis; and a fixing device for fixing the adjusting element and the actuating body in a selectable position. The invention also relates to a passenger or freight transport vehicle with such a device.

Abstract: A measurement instrument and its associated method of use to record a pupil center position of a person's eye and determine rear vertex distance to a lens. The instrument has a chassis and a free swinging assembly that is pivotably attached to the chassis. The swinging assembly has alignment points that remain in a horizontal plane as the swinging assembly swings. The instrument is attached to a set of eyeglass that are worn on that person's head. A prism is suspended adjacent the eye. The pupil is viewed through the prism. The offset of the viewed image is measured and used to calculate the rear vertex distance.

Abstract: A patient manager provides activity recommendations to a patient based on monitored data. The patient manager monitors personal, environmental, and external data to identify baseline and personal best thresholds to determine appropriate activity recommendations for a patient that is trying to manage a disease such as asthma. A personal monitor measures a peak flow rate by having the patient blow through the personal monitor. An environmental monitor measures ambient conditions in a room and communicates the conditions with the patient manager. The patient manager also pulls in third-party regional weather information, and generates activity recommendations based on the personal, environmental, and regional information.

Abstract: A gas-impervious container having a gas-permeable porous insert, wherein the insert contacts a flowable biomedical material, for improving access of the sterilant gas to the material.

Abstract: A method and apparatus for treating a coal combustion flue gas. In one embodiment, the method includes injecting a halogen into a flue gas, and injecting partially combusted, carbon enriched alkaline coal ash solid particles into the flue gas ahead of a particulate collection device. In another embodiment, the method includes exposing partially combusted, carbon enriched alkaline coal ash solid particles to a halogen containing atmosphere, and injecting the halogen atmosphere treated alkaline carbon containing solid particles into the flue gas ahead of a particulate collection device.

Abstract: A gas-impervious container having a gas-permeable porous insert, wherein the insert contacts a flowable biomedical material, for improving access of the sterilant gas to the material.

Abstract: A gas-impervious container having a gas-permeable porous insert, wherein the insert contacts a flowable biomedical material, for improving access of the sterilant gas to the material.

Abstract: A method for recording changing boiler conditions over time in three spatial dimensions including: sensing the boiler conditions in real time using sensors which traverse the combustion chamber and gas path generating data from a plurality of positions in one or more supervisory spaces of interest within the boiler system; transmitting the generated data to a computer system; presenting data containing sensor position information and which optionally contains temperature, chemical species information, and other combustor condition information for delivery to a boiler management system to enable said boiler management system to make real time operational adjustments.

Abstract: A method and apparatus for treating a coal combustion flue gas. In one embodiment, the method includes injecting a halogen into a flue gas, and injecting partially combusted, carbon enriched alkaline coal ash solid particles into the flue gas ahead of a particulate collection device. In another embodiment, the method includes exposing partially combusted, carbon enriched alkaline coal ash solid particles to a halogen containing atmosphere, and injecting the halogen atmosphere treated alkaline carbon containing solid particles into the flue gas ahead of a particulate collection device.

Abstract: A measurement instrument and its associated method of use to record a pupil center position of a person's eye and determine rear vertex distance to a lens. The instrument has a chassis and a free swinging assembly that is pivotably attached to the chassis. The swinging assembly has alignment points that remain in a horizontal plane as the swinging assembly swings. The instrument is attached to a set of eyeglass that are worn on that person's head. A prism is suspended adjacent the eye. The pupil is viewed through the prism. The offset of the viewed image is measured and used to calculate the rear vertex distance.

Abstract: A measurement instrument and its associated method of use to record a pupil center position of a person's eye. The instrument has a chassis and a free swinging assembly that is pivotably attached to the chassis. The swinging assembly has alignment points that remain in a horizontal plane as the swinging assembly swings. The instrument is attached to a set of eyeglass that are worn on that person's head. While wearing the measuring instrument, a person is made to assume a natural head position for a specific activity. Once a natural head position is found, the swinging assembly is set into a locked position. The pupil center point can then be determined by observing the now locked alignment points from a predetermined vantage point.

Abstract: A gas-impervious container having a gas-permeable porous insert, wherein the insert contacts a flowable biomedical material, for improving access of the sterilant gas to the material.

Abstract: A measurement instrument and its associated method of use to record a pupil center position of a person's eye. The instrument has a chassis and a free swinging assembly that is pivotably attached to the chassis. The swinging assembly has alignment points that remain in a horizontal plane as the swinging assembly swings. The instrument is attached to a set of eyeglass that are worn on that person's head. While wearing the measuring instrument, a person is made to assume a natural head position for a specific activity. Once a natural head position is found, the swinging assembly is set into a locked position. The pupil center point can then be determined by observing the now locked alignment points from a predetermined vantage point.

Abstract: The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the insulin resistance syndrome (IRS). It is such a process that the present inventions sets out to define, and more particularly for the preparation of the (S)-enantioner of certain 2-ethoxy-3-(4-hydroxyphenyl)propanoic acids and derivatives thereof.

Abstract: The present invention relates to universal joints, and more particularly, to an apparatus and method for servicing staked universal joints as well as a u-joint serviced with the method and apparatus of the present invention. The service kit includes a replacement bearing assembly, a retention assembly and a spacer sized to fit between the retention assembly and the replacement bearing assembly. The method generally includes the steps of removing the stakes from an aperture on a driveshaft, removing an original bearing assembly from the aperture, inserting the replacement bearing assembly into the aperture, inserting the spacer into the aperture and retaining the spacer and replacement bearing assembly within the aperture with the retention assembly.

Abstract: A low profile cable connector includes a mating connector face, and first and second lateral sides extending from said mating connector face. One of the first and second sides comprises a bail latch retainer thereon, and a jack screw latch is located adjacent the other of said first and second sides. The cable exit extends from one of the first and second sides at an angle to the mating connector face. The bail latch retainer comprises a bail latch slot, and the jack screw extends through a top surface of the connector. The connector is defined by first and second backshells joined to one another.

Abstract: Methods and structures for integrated presentation of data from legacy systems utilized in pharmaceutical development enterprises. Aspects of the invention retrieve data from any of a plurality of legacy systems. The retrieved data may be converted to XML messages and may be forwarded through a centralized portal server for integrated presentation to a user. In another aspect of the invention, the XML messages may be used to automatically generate and submit regulatory submission information regarding the new pharmaceutical development. Legacy systems may include any systems used in pharmaceutical development including, for example: manufacturing, marketing, analytical services, clinical trials, registration, project management and lab management.