Patents by Inventor Eric Gaucher
Eric Gaucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12012077Abstract: The present invention relates to an adapter (1) for a wiper system (6), comprising at least a side wall (10) and an upper wall (12) having at least one common edge between them, the side wall (10) and the upper wall (12) helping to define an inner volume of the adapter (1), the adapter (1) comprising a first inner wall (20) and a second inner wall (66) helping to delimit, at least partially, a receiving area (26) intended to receive the connector (8), the adapter (1) comprising at least one receiving housing (32) which is intended to receive the arm and which has a rectangular cross section defined by two major sides (33) and two minor sides (31), characterized in that a straight line (D) passing through one of the major sides (33) cuts the receiving area (26) intended to receive the connector (8).Type: GrantFiled: September 1, 2022Date of Patent: June 18, 2024Assignee: VALEO SYSTÈMES D'ESSUYAGEInventors: Vincent Gaucher, Stephane Houssat, Eric Poton, Olivier Jomard
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Patent number: 11975695Abstract: An adapter (1) for securing a wiper on an arm of a wiper system, the adapter (1) extending in a longitudinal direction (L), the adapter (1) being configured to be fitted such as to rotate on a connector of the wiper around an axis of rotation transverse to the longitudinal direction (L), the adapter (1) comprising at least one lateral wall (10) and one upper wall (12), the lateral wall (10) and the upper wall (12) participating in defining an inner volume of the adapter (1), the adapter (1) comprising an inner wall (20) extending at least partly into the inner volume of the adapter (1), the adapter (1) comprises a locking device (22) which is designed to render the adapter integral longitudinally relative to the arm of the wiper system, the locking device being fitted such as to pivot on the upper wall around an axis of pivoting.Type: GrantFiled: August 31, 2022Date of Patent: May 7, 2024Assignee: VALEO SYSTÈMES D'ESSUYAGEInventors: Vincent Gaucher, Stéphane Houssat, Eric Poton, Olivier Jomard
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Patent number: 11897938Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: GrantFiled: June 23, 2021Date of Patent: February 13, 2024Assignees: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATIONInventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
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Patent number: 11633504Abstract: Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B.Type: GrantFiled: May 9, 2018Date of Patent: April 25, 2023Assignees: EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC., GEORGIA TECH RESEARCH CORPORATIONInventors: Christopher Doering, Harold Trent Spencer, Eric Gaucher, Caelan Radford
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Publication number: 20210388055Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: ApplicationFiled: June 23, 2021Publication date: December 16, 2021Applicants: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATIONInventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
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Patent number: 11046750Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: GrantFiled: May 14, 2020Date of Patent: June 29, 2021Assignees: Emory University, Georgia Tech Research CorporationInventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
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Publication number: 20210052740Abstract: Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B.Type: ApplicationFiled: May 9, 2018Publication date: February 25, 2021Inventors: Christopher DOERING, Harold Trent SPENCER, Eric GAUCHER, Caelan RADFORD
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Publication number: 20200347116Abstract: A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.Type: ApplicationFiled: November 1, 2018Publication date: November 5, 2020Inventors: Philip ZAKAS, David LILLICRAP, Christopher DOERING, Eric GAUCHER, Caelan RADFORD, Harold Trent SPENCER
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Publication number: 20200277356Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: ApplicationFiled: May 14, 2020Publication date: September 3, 2020Applicants: EMORY UNIVERSITY, GEORGIA TECH RESEARCH CORPORATIONInventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
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Patent number: 10654910Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: GrantFiled: January 27, 2016Date of Patent: May 19, 2020Assignees: Emory University, Georgia Tech Research CorporationInventors: H. Trent Spencer, Christopher Doering, Philip M. Zakas, Eric Gaucher
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Publication number: 20180016562Abstract: The invention provides a method tar increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures The invention farther provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower pH than extant thioredoxin polypeptides, as well as paleoenzymologically reconstructed thioredoxin polypeptides having higher melting temperatures than extant thioredoxin polypepetides.Type: ApplicationFiled: July 27, 2017Publication date: January 18, 2018Inventors: Julio M. FERNANDEZ, Raul PEREZ-JIMENEZ, Eric GAUCHER, Pallav KOSURI
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Publication number: 20180009873Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.Type: ApplicationFiled: January 27, 2016Publication date: January 11, 2018Inventors: Trent H. Spencer, Christopher Doering, Philip M. Zakas, Eric Gaucher
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Patent number: 9428737Abstract: This patent applications concerns compositions of matter that are DNA polymerases, where those polymerases have had one or more of their amino acids replaced at sites chosen by an analysis of patterns of conservation and replacement within homologous protein sequences. Disclosed here are sites within Family A DNA polymerases where amino acid replacement creates polymerases having utility, in an example where DNA nucleotides are incorporated having modified or unnatural nucleobases, and/or nucleotides whose sugar is unnatural or derivatized, including 3?-O-amino-2?-deoxyribonucleoside triphosphates. The claimed compositions include polymerases that hold amino acid replacements at claimed sites in Taq polymerase, and are prepared by site-directed mutagenesis that modifies a gene encoding a parent Taq gene (natural or already mutated) to change the codon encoding the amino acid at the claimed site, giving a variant gene that encodes a Taq polymerase protein that has a different amino acid at the claimed site.Type: GrantFiled: January 11, 2010Date of Patent: August 30, 2016Inventor: Eric Gaucher
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Patent number: 8940861Abstract: The present invention provides uricases and methods of their production and use in reducing the amount of uric acid in a subject. The present invention further provides methods employing a uricase of this invention in the treatment and/or prevention of hyperuricemia, gout, tumor lysis syndrome and/or hypertension in a subject.Type: GrantFiled: April 8, 2011Date of Patent: January 27, 2015Assignee: Georgia Tech Research CorporationInventor: Eric A. Gaucher
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Publication number: 20130252307Abstract: The invention provides a method for increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures. The invention further provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower pH than extant thioredoxin polypepetides, as well as paleoenzymologically reconstructed thioredoxin polypeptides having higher melting temperatures than extant thioredoxin polypepetides.Type: ApplicationFiled: July 15, 2011Publication date: September 26, 2013Applicant: GEORGIA TECH RESEARCH CORPORATIONInventors: Julio M. Fernandez, Raul Perez-Jimenez, Eric Gaucher, Pallav Kosuri
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Publication number: 20110268713Abstract: The present invention provides uricases and methods of their production and use in reducing the amount of uric acid in a subject. The present invention further provides methods employing a uricase of this invention in the treatment and/or prevention of hyperuricemia, gout, tumor lysis syndrome and/or hypertension in a subject.Type: ApplicationFiled: April 8, 2011Publication date: November 3, 2011Inventor: Eric A. Gaucher