Abstract: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroarylalkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v.

Abstract: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v.

Abstract: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome (e.g., obesity, waist circumference, lipid profile, and insulin sensitivity), neuroinflammatory disorders, cognitive disorders, psychosis, addictive behavior, gastrointestinal disorders, and cardiovascular conditions.

Abstract: A regenerative load that includes an input configured to draw a specified current and an output configured to provide an output voltage and current is described. The regenerative load configured to maintain the output voltage to cause the regenerative load to draw the specified current from the unit under test. The output of the regenerative load is provided back to the input of the unit under test. The input current or voltage can be AC, DC, or a combination of AC and DC. The output current or voltage can be AC, DC, or a combination of AC and DC. In one embodiment, a thermal barrier is provided between a test chamber and a load chamber to allow converters under test to be operated at a test temperature while the regenerative loads are operated at a desired operational temperature.

Abstract: A method and apparatus enabling migration of clients to a specific version of a server-hosted application, where multiple software versions of the server-hosted application are installed on the network, such that clients using the application experience minimal downtime related to upgrades and revisions of the application. When a new version of the application is to be deployed, a selected small portion of the clients is directed to the new version, to verify the functionality of that version, while the remaining clients use the previous version. If problems are discovered in the new version, the upgrade is terminated without impacting all of the clients. A register retains the identity of the clients and the version of the software with which each client is associated. The direction of the selected portion of clients to the new version of the software is done in a manner that can be completely transparent to the clients.

Abstract: A door assembly of the type having a frame mounted to a wall. The frame comprises a head portion, opposed vertical jamb portions and a sill portion. Doors are provided in the frame. A door in the frame is displaceable between an open position and a closed position. The doors comprise a sash portion supporting a see-through panel. Each of the head portion, the jamb portion, the sill portion, and the sash portion of the door has one external cladding and one internal cladding. The external cladding and the internal cladding are detachably connected to one another, such that only the external cladding is exposed to an exterior of the door assembly and only the internal cladding is exposed to an interior of the door assembly when the door is in the closed position. A method for interconnecting two hollow elongated extruded sections of the door sash is also provided.

Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

Abstract: A regenerative load that includes an input configured to draw a specified current and an output configured to provide an output voltage and current is described. The regenerative load configured to maintain the output voltage to cause the regenerative load to draw the specified current from the unit under test. The output of the regenerative load is provided back to the input of the unit under test. The input current or voltage can be AC, DC, or a combination of AC and DC. The output current or voltage can be AC, DC, or a combination of AC and DC. In one embodiment, a thermal barrier is provided between a test chamber and a load chamber to allow converters under test to be operated at a test temperature while the regenerative loads are operated at a desired operational temperature.

Abstract: The heat exchanger plate presents first adjacent first corrugations generally directed along respective alignment axes in the longitudinal direction of the plate and comprising successive segments that are substantially rectilinear and oblique, being successively inclined in a first sense and in a second sense relative to the longitudinal axis. The heat exchanger plate also has at least one deformation zone constituted by at least one set of segments of second corrugations of generally transverse direction intersecting the set of longitudinal axes along which the first corrugations are disposed. The alignment axes of the segments of second corrugations make an angle lying in the range 45° to 90° with the longitudinal axes of the first corrugations.

Abstract: Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.

Abstract: In the present disclosure, systems and methods for preventing collisions between a ground services vehicle and other objects are described. In one embodiment, a system includes a digital three dimensional map of the outer dimensions of the ground vehicle, a micro radar device, a comparator, and an indicator. The micro radar device is secured to the ground vehicle. A comparator signals when an object is within a predetermined envelope around the outer dimensions of the ground vehicle. The comparator receives signals from the micro radar device, and includes dimension data from the three dimensional map. The indicator is responsive to the signal from the comparator. The indicator alerts of possible and pending collision when the predetermined envelope is breached. The indicator may also activate a brake mechanism to stop the ground vehicle. Methods for carrying out the invention by sensing a breach of the envelope and stopping the vehicle are also disclosed.

Abstract: Apparatus and method for creating de-identified and linked records is described. More particularly, data records are de-identified at a client computer. De-identification includes field-level one-way encryption. De-identified records may then be sent to a server computer for linkage. Linkage is done using match codes created for such data records at the client computer. The server computer is configured to provide longitudinal linkage of de-identified client records to de-identified master records. In this manner, privacy may be maintained at the client computer prior to transmission of information, and longitudinal linkage of records may occur without exposing personally identifying information.

Abstract: The use of CCR3 antagonists of the formula I or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula II, pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.

Abstract: Plates of a heat exchanger plate pack are formed by a stack of plates defining at least two independent fluid flow circuits, each circuit comprising a central heater part and a border with a smooth surface. A cutout is produced on corners of each plate and on the border to be connected, of each plate to the adjacent plate, a fold is made in order to form a first flange. On this first flange a fold is made in order to form a second flange laying parallel to the central part of the corresponding plate and directed outward from the plate. The plates are superposed and held by applying the second flange of each plate to the second flange of the adjacent plate. A continuous sealed weld bead is made by completely melting the second superposed flanges of adjacent plates.

Abstract: The heat exchanger plate presents first adjacent first corrugations generally directed along respective alignment axes in the longitudinal direction of the plate and comprising successive segments that are substantially rectilinear and oblique, being successively inclined in a first sense and in a second sense relative to the longitudinal axis. The heat exchanger plate also has at least one deformation zone constituted by at least one set of segments of second corrugations of generally transverse direction intersecting the set of longitudinal axes along which the first corrugations are disposed. The alignment axes of the segments of second corrugations make an angle lying in the range 45° to 90° with the longitudinal axes of the first corrugations.

Abstract: The use of CCR5 antagonists of the formula 1

Abstract: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v, host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV o

Abstract: A door assembly of the type having a frame mounted to a wall. The frame comprises a head portion, opposed vertical jamb portions and a sill portion. Doors are provided in the frame. A door in the frame is displaceable between an open position and a closed position. The doors comprise a sash portion supporting a see-through panel. Each of the head portion, the jamb portion, the sill portion, and the sash portion of the door has one external cladding and one internal cladding. The external cladding and the internal cladding are detachably connected to one another, such that only the external cladding is exposed to an exterior of the door assembly and only the internal cladding is exposed to an interior of the door assembly when the door is in the closed position. A method for interconnecting two hollow elongated extruded sections of the door sash is also provided.

Abstract: The invention concerns a method for assembling plates (1) of a plate pack for a heat exchanger formed by a stack of plates. The invention is characterised in that it consists in producing on the edge of each plate (1) to be connected with the adjacent plate (1) a welt to form a first flange (7; 9); in producing on said first flange a welt to form a second flange (11; 13) of the adjacent plate; and in producing a continuous and sealed weld seam by melting the stacked second flanges (11; 13) of the adjacent plates (1).

Abstract: The use of CCR5 antagonists of the formula 1