Patents by Inventor Eric H. Hill
Eric H. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10750746Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.Type: GrantFiled: November 15, 2018Date of Patent: August 25, 2020Assignees: University of Florida Research Foundation, Inc., STC.UNMInventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
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Publication number: 20200158720Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.Type: ApplicationFiled: December 9, 2019Publication date: May 21, 2020Inventors: David G. Whitten, Harry Craig Pappas, Eric H. Hill, Yue Zhang, Eva Yung Hua Chi, Arjun Thapa, Ying Wang, Patrick L. Donabedian, Kiran Bhaskar
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Patent number: 10638759Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3-R4 j times and 2,5-bonded thiophene substituted by —X—R3-R4 j times. At each occurrence, Y is independently chosen from a bond and —C?C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C?C—. The variables j, R3, and R4 are as defined herein.Type: GrantFiled: August 3, 2017Date of Patent: May 5, 2020Assignees: University of Florida Research Foundation, Inc., STC.UNMInventors: David G. Whitten, Harry Craig Pappas, Eric H. Hill, Kirk S. Schanze, Anand Parthasarathy, Yun Huang, Thomas S. Corbitt
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Patent number: 10533991Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.Type: GrantFiled: March 13, 2015Date of Patent: January 14, 2020Assignee: STC.UNMInventors: David G. Whitten, Harry Pappas, Eric H. Hill, Yue Zhang, Eva Yung Hua Chi, Arjun Thapa, Ying Wang, Patrick L. Donabedian, Kiran Bhaskar
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Publication number: 20190116797Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.Type: ApplicationFiled: November 15, 2018Publication date: April 25, 2019Inventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
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Patent number: 10174042Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.Type: GrantFiled: November 10, 2016Date of Patent: January 8, 2019Assignees: STC.UNM, University of Florida Research Foundation, Inc.Inventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
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Patent number: 10092000Abstract: The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.Type: GrantFiled: July 13, 2011Date of Patent: October 9, 2018Assignees: STC.UNM, University of Florida Research Foundation, Inc.Inventors: David G. Whitten, Kirk S. Schanze, Eunkyung Ji, Thomas S. Corbitt, Zhijun Zhou, Dimitri Dascier, Ying Wang, Linnea K. Ista, Anand Parthasarathy, Eric H. Hill, Yanli Tang
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Patent number: 9968698Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.Type: GrantFiled: November 5, 2014Date of Patent: May 15, 2018Assignee: STC. UNMInventors: David G. Whitten, Eric H. Hill, Harry C. Pappas
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Publication number: 20180020663Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C?C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C?C—. The variables j, R3, and R4 are as defined herein.Type: ApplicationFiled: August 3, 2017Publication date: January 25, 2018Inventors: David G. Whitten, Harry Craig Pappas, Eric H. Hill, Kirk S. Schanze, Anand Parthasarathy, Yun Huang, Thomas S. Corbitt
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Patent number: 9750250Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C?C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C?C—. The variables j, R3, and R4 are as defined herein.Type: GrantFiled: February 8, 2016Date of Patent: September 5, 2017Assignees: STC.UNM, University of Florida Research Foundation, Inc.Inventors: David G. Whitten, Harry Craig Pappas, Eric H. Hill, Kirk S. Schanze, Anand Parthasarathy, Yun Huang, Thomas S. Corbitt
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Publication number: 20170057970Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.Type: ApplicationFiled: November 10, 2016Publication date: March 2, 2017Inventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
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Publication number: 20170023554Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.Type: ApplicationFiled: March 13, 2015Publication date: January 26, 2017Inventors: David G. Whitten, Harry Pappas, Eric H. Hill, Yue Zhang, Eva Yung Hua Chi, Arjun Thapa, Ying wang, Patrick L. Donabedian, Kiran Bhaskar
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Patent number: 9527806Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.Type: GrantFiled: July 13, 2011Date of Patent: December 27, 2016Assignees: STC.UNM, University of Florida Research Foundation, Inc.Inventors: David G. Whitten, Kirk S. Schanze, Anand Parthasarathy, Eunkyung Ji, Motokatsu Ogawa, Thomas S. Corbitt, Dimitri Dascier, Ying Wang, Linnea K. Ista, Eric H. Hill
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Publication number: 20160222150Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C?C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C?C—. The variables j, R3, and R4 are as defined herein.Type: ApplicationFiled: February 8, 2016Publication date: August 4, 2016Inventors: David G. Whitten, Harry Craig Pappas, Eric H Hill, Kirk S. Schanze, Anand Parthasarathy, Yun Huang, Thomas S. Corbitt
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Publication number: 20150132184Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.Type: ApplicationFiled: November 5, 2014Publication date: May 14, 2015Inventors: David G. Whitten, Eric H. Hill, Harry C. Pappas
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Publication number: 20120322977Abstract: An inorganic nanoparticle array is self-assembled onto an unpatterned or patterned, peptide-functionalized substrate surface using peptide constructs comprising a substrate-binding peptide and a mineralization peptide.Type: ApplicationFiled: June 19, 2012Publication date: December 20, 2012Inventor: Eric H. Hill