Abstract: Patterned hydrogel arrays and methods of preparing patterned hydrogel arrays are disclosed. Advantageously, the methods used to prepare the patterned hydrogel arrays allow for controlling individual hydrogel spot conditions such as hydrogel spot modulus, hydrogel spot ligand identity and hydrogel spot ligand density, which allows for preparing a wide range of hydrogel spots in a single array format. Patterned hydrogel arrays can also be formed to include hydrogel-free pools surrounded by hydrogel. Additionally, the patterned hydrogel arrays of the present disclosure support the culture of a range of cell types. The patterned hydrogel arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.

Abstract: Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.

Abstract: Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.

Abstract: Patterned hydrogel arrays and methods of preparing patterned hydrogel arrays are disclosed. Advantageously, the methods used to prepare the patterned hydrogel arrays allow for controlling individual hydrogel spot conditions such as hydrogel spot modulus, hydrogel spot ligand identity and hydrogel spot ligand density, which allows for preparing a wide range of hydrogel spots in a single array format. Patterned hydrogel arrays can also be formed to include hydrogel-free pools surrounded by hydrogel. Additionally, the patterned hydrogel arrays of the present disclosure support the culture of a range of cell types. The patterned hydrogel arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.

Abstract: A method for determination of mechanical integrity of bone includes embedding a threaded rod into the bone, extracting the threaded rod out of the bone, and measuring the force required to extract the threaded rod from the bone, wherein the force required to extract the threaded rod is indicative of the mechanical integrity of the bone. A device for determining the mechanical integrity of bone includes a housing, a rod holder mounted to the housing and configured to hold a threaded rod which is embedded in the bone, a pulling force applicator which applies a pulling force to the rod holder to extract the threaded rod from the bone, and a pulling force measuring instrument which measures the pulling force applied to the rod holder by the pulling force applicator as the threaded rod is extracted from the bone.

Abstract: A method for determination of mechanical integrity of bone includes embedding a threaded rod into the bone, extracting the threaded rod out of the bone, and measuring the force required to extract the threaded rod from the bone, wherein the force required to extract the threaded rod is indicative of the mechanical integrity of the bone. A device for determining the mechanical integrity of bone includes a housing, a rod holder mounted to the housing and configured to hold a threaded rod which is embedded in the bone, a pulling force applicator which applies a pulling force to the rod holder to extract the threaded rod from the bone, and a pulling force measuring instrument which measures the pulling force applied to the rod holder by the pulling force applicator as the threaded rod is extracted from the bone.