Abstract: The present disclosure provides methods for the rapid synthesis of large libraries of spherical nucleid acid (SNA) nanoparticles, their screening for activity, and a machine learning algorithm to analyze the data.

Abstract: The disclosure provides a cell-based, label-free assay compatible with high-throughput screening (HTS) that can report quantitatively on enzyme activities by measuring mass changes of substrates with MALDI-mass spectrometry.

Abstract: The disclosure provides a cell-based, label-free assay compatible with high-throughput screening (HTS) that can report quantitatively on enzyme activities by measuring mass changes of substrates with MALDI-mass spectrometry.

Abstract: An end effector is configured to grasp articles that have deviated from their original shape. The end effector can return the article to its expected condition. The end effector can include a main platform, a first sub-platform and a second sub-platform. A first suction cup extends vertically below the main platform. Each of the sub-platforms includes one or more suction cups, respectively, that protrude vertically below the sub-platforms. Each sub-platform is connected to the main platform via a bellows actuator that can be extended and retracted via positive and negative pressures. The main platform can include fittings to allow the end effector to be attached to a wide variety of robotic arms, such as a delta robot.

Abstract: The disclosure provides a cell-based, label-free assay compatible with high-throughput screening (HTS) that can report quantitatively on enzyme activities by measuring mass changes of substrates with MALDI-mass spectrometry.

Abstract: An end effector is configured to grasp articles that have deviated from their original shape. The end effector can return the article to its expected condition. The end effector can include a main platform, a first sub-platform and a second sub-platform. A first suction cup extends vertically below the main platform. Each of the sub-platforms includes one or more suction cups, respectively, that protrude vertically below the sub-platforms. Each sub-platform is connected to the main platform via a bellows actuator that can be extended and retracted via positive and negative pressures. The main platform can include fittings to allow the end effector to be attached to a wide variety of robotic arms, such as a delta robot.

Abstract: The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration.

Abstract: The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration.

Abstract: A fouling resistant fluid dispensing assembly including a metering device and a nozzle assembly. The nozzle assembly generally includes a nozzle holder including a body defining a cylindrical bore. The nozzle has a cylindrical portion proportioned to be inserted into the cylindrical bore in a close fitting relationship. The nozzle holder is pierced by a passage oriented substantially perpendicular to the bore axis and passing through the cylindrical bore on a non-diametrical chord and the nozzle has a complementary passage that can be aligned with the nozzle holder passage. Once the holder passage and the nozzle passage are aligned, a retaining member proportioned to pass through the nozzle holder passage and the nozzle passage retains the nozzle in the cylindrical bore. The fluid dispensing assembly further includes a floating head and a mass distribution to maintain a viscous fluid at a desired temperature.