Abstract: A method for automatically processing a biological fluid is disclosed. The method includes the steps of obtaining a container having a biological fluid therein, providing a first signal and communicating with an automated control arrangement to establish flow of at least a portion of the biological fluid along a fluid flow path through a leukocyte depletion medium, providing a second signal and communicating with the automatic control arrangement to terminate flow along the fluid flow path wherein providing the second signal includes sensing the back pressure in the fluid flow path or the flow rate through the leukocyte depletion medium.

Abstract: An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier/leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.

Abstract: An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly including a first container operatively associated with the pressure differential generator, at least one satellite container in fluid communication with the first container and a porous medium including a leukocyte depletion medium interposed between the first container and the satellite container and a sensor downstream of the porous medium for sensing and providing a signal reflecting the presence of red blood cells downstream of the porous medium. An automated control arrangement is coupled to the sensor to receive the signal from the sensor and coupled to at least one of the pressure differential generator and the biological fluid processing assembly to control flow between the first container and the satellite container.