Patents by Inventor Eric J. Rubin

Eric J. Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatments for
    Patent number: 9925251
    Abstract: The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: March 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Tatos Akopian, Olga Kandror, Alfred Lewis Goldberg, Ravikiran M. Raju, Meera Unnikrishnan, Eric J. Rubin
  • TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20140243255
    Abstract: The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.
    Type: Application
    Filed: October 19, 2012
    Publication date: August 28, 2014
    Inventors: Olga Kandror, Alfred Lewis Goldberg, Tatos Akopian, Eric J. Rubin, Ravikiran M. Raju
  • Hyperactive mutants of Himar1 transposase and methods for using the same
    Patent number: 6368830
    Abstract: Mariner-family transposable elements are active in a wide variety of organisms and are becoming increasingly important genetic tools in species lacking sophisticated genetics. The Himar1 element, a member of the mariner family, isolated from the horn fly, Haematobia irritans, is active in Escherichia coli when expressed appropriately. Using this fact, a genetic screen was devised to isolate hyperactive mutants of Himar1 transposase that enhance overall transposition from 4 to 50-fold as measured in an E. coli assay. These hyperactive Himar1 mutant transposases should enable sophisticated analysis of the biochemistry of mariner transposition and should improve efficiency of a variety of genetic manipulations involving transposition in vivo and in vitro such as random mutagenesis or transgenesis in a wide range of host cells than the transposable elements previously available.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: April 9, 2002
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the University of Illinois
    Inventors: David J. Lampe, Hugh M. Robertson, Eric J. Rubin, Brian J. Akerley
  • Systematic identification of essential genes by in vitro transposon mutagenesis
    Patent number: 6207384
    Abstract: The invention features a general system for the identification of essential genes in organisms. This system is applicable to the discovery of novel target genes for antimicrobial compounds, as well as to the discovery of genes that enhance cell growth or viability.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: March 27, 2001
    Assignees: The General Hospital Corporation, Trustees of Tufts College, President and Fellows of Harvard College
    Inventors: John J. Mekalanos, Brian J. Akerley, Eric J. Rubin, Andrew Camilli
  • Carrier for portable electronic devices
    Patent number: D707958
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: July 1, 2014
    Assignee: SMR Enterprises Inc.
    Inventor: Eric J. Rubin