Abstract: A method of coating a substrate including loading a calcium phosphate substance at a first crystallinity with a therapeutic agent; depositing the loaded calcium phosphate substance at the first crystallinity onto a least a portion of the substance; loading a calcium phosphate substance at a second, lower, crystallinity with a therapeutic agent; and depositing the loaded calcium phosphate substance at the second crystallinity onto the deposited loaded calcium phosphate substance at the first crystallinity to control and sustain a long-term osseointegration response and to control the release rate of the therapeutic substance from the calcium phosphate substance.

Abstract: Polymeric implants provided with coatings of bactericidal compounds in the form of ionized atoms by a vapor process. The polymeric implants include products designed to penetrate or enter the body, such as catheters, shunts connectors and the like. Coatings of bactericidal compounds on the polymeric implants are intended to make their use safe. The coatings are formed thereon in the form of ionized atoms of the compounds by ion-beam-assisted deposition in a vacuum chamber. The vacuum chamber is provided, inter alia, with an evaporator and an ion source mounted in operative association therein, including means for rotatably mounting a plurality of polymeric implants for exposure to the evaporator and the ion source.

Abstract: An improved surgical implant, formed of cobalt-chromium and its alloys in contact with a bearing surface formed by UHMWPE, and a process of its manufacture are disclosed. The improved surgical implant is designed to reduce the wear of the UHMPE component of the surgical implant, enhancing its useful life. The process essentially includes the ion implantation of the cobalt-chromium component, with a resultant increase in its microhardness and a decrease in its coefficient of friction, particularly when articulating against the UHMWPE component.