Abstract: A system for use during surgical procedures. The system includes an implant and a tool. The implant combines a modular adjustable cage and a shim that locks the cage into position, after the cage has been adjusted to its final position and at its final height, in situ. The tool combines an expander and an inserter. A related method of using the system is also provided.

Abstract: A catheter interface protection device can include a shield. The shield can include an open bottom, a transparent upper surface, sidewalls, and a cavity at least partially defined by the bottom, the upper surface, and the sidewalls. The device can include a vent. The device can include a clip, a tether, and a latch. A non-therapeutic method of protecting a catheter interface can include extending a catheter in the subject through a slot in a catheter interface protection device, wrapping the catheter at least partially around a clip of the catheter interface protection device, and securing a latch of the catheter interface protection device around the clip. A device for positioning a subject in a prone position can include a padded area including an opening configured to accommodate a catheter interface protection device.

Abstract: A golf ball including an outer surface having dimples located on the outer surface, at least one core, at least one mantle layer, at least one cover layer, and a plurality of images located on the outer surface, the images being provided with at least two contrasting colors, wherein the plurality of images each have a Major Peak Ratio of between 0.18 and 1, a Major Valley Ratio of between 0.18 and 1, a slope value of between ?5 and 5, and an intercept value between 5 and 80.

Abstract: Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.

Abstract: Detecting analytes using proximity-induced tagmentation, strand invasion, restriction, or ligation is provided herein. In some examples, detecting an analyte includes coupling a donor recognition probe to a first portion of the analyte. The donor recognition probe includes a first recognition element specific to the first portion of the analyte, a first oligonucleotide corresponding to the first portion, and a transposase coupled to the first recognition element and the first oligonucleotide. An acceptor recognition probe is coupled to a second portion of the analyte. The acceptor recognition probe includes a second recognition element specific to the second portion of the analyte and a second oligonucleotide coupled to the second recognition element and corresponding to the second portion. The transposase is used to generate a reporter polynucleotide including the first and second oligonucleotides. The analyte is detected based on the reporter including comprising the first and second oligonucleotides.

Abstract: A system for use during surgical procedures. The system includes an implant and a tool. The implant combines a modular adjustable cage and a shim that locks the cage into position, after the cage has been adjusted to its final position and at its final height, in situ. The tool combines an expander and an inserter. A related method of using the system is also provided.

Abstract: An apparatus includes a body, and anchoring feature, and a guide feature. The body is sized and configured to be positioned on an eye of a patient. The anchoring feature is configured to secure the body to the eye of the patient. The guide feature is configured to guide a cannula into a scleral incision formed in the eye of the patient along a path that is substantially tangential relative to the eye of the patient. The guide feature is sized and configured to allow the cannula to pivot laterally through a range of angular motion at the scleral incision.

Abstract: Implants for vertebral body or functional spinal unit replacement comprise a bioactive surface roughening on one or more of the anterior, posterior, and lateral surfaces of the implant. The bioactive surface includes macro-, micro-, and nano-scale structural features that contact vertebral bone that lines a specialized channel in a vertebrae, and thereby facilitate bone growth and osteointegration of the implant with the vertebral bone.

Abstract: A system for use during surgical procedures. The system includes an implant and a tool. The implant combines a modular adjustable cage and a shim that locks the cage into position, after the cage has been adjusted to its final position and at its final height, in situ. The tool combines an expander and an inserter. A related method of using the system is also provided.

Abstract: A system for use during surgical procedures. The system includes an implant and a tool. The implant combines a modular adjustable cage and a shim that locks the cage into position, after the cage has been adjusted to its final position and at its final height, in situ. The tool combines an expander and an inserter. A related method of using the system is also provided.

Abstract: Implants for vertebral body or functional spinal unit replacement comprise a bioactive surface roughening on one or more of the anterior, posterior, and lateral surfaces of the implant. The bioactive surface includes macro-, micro-, and nano-scale structural features that contact vertebral bone that lines a specialized channel in a vertebrae, and thereby facilitate bone growth and osteointegration of the implant with the vertebral bone.

Abstract: Implants for vertebral body or functional spinal unit replacement comprise a bioactive surface roughening on one or more of the anterior, posterior, and lateral surfaces of the implant. The bioactive surface includes macro-, micro-, and nano-scale structural features that contact vertebral bone that lines a specialized channel in a vertebrae, and thereby facilitate bone growth and osteointegration of the implant with the vertebral bone.

Abstract: A screwdriver for resisting premature disengagement of a screw from the screwdriver. The screwdriver includes a shaft having a central axis; a tip radially aligned with the central axis of the shaft which includes an end opposite the shaft, at least one radial protrusion extending away from the central axis, and a notch; and a screw retention mechanism including a flexible member aligned with the notch and attached to either the tip or the shaft. The flexible member has an unattached end which is separated from the second end of the tip. When the tip is inserted into a recess of a screw, the flexible member flexes toward the central axis and creates an opposing elastic force which holds the screw to the tip.

Abstract: A system for use during surgical procedures. The system includes an implant and a tool. The implant combines a modular adjustable cage and a shim that locks the cage into position, after the cage has been adjusted to its final position and at its final height, in situ. The tool combines an expander and an inserter. A related method of using the system is also provided.

Abstract: A system for affixing a stop plate to an interbody implant. The system includes a clamping device, a stop plate, and an inserter tool. The clamping device includes a body, a first clamping portion attached to the body including a stepped seat and a guide slot, and a second clamping portion attached to the body by a spring. Compressing the spring moves the second clamping portion away from the first clamping portion and expanding the spring moves the second clamping portion toward the first clamping portion.

Abstract: A screwdriver for resisting premature disengagement of a screw from the screwdriver. The screwdriver includes a shaft having a central axis; a tip radially aligned with the central axis of the shaft which includes an end opposite the shaft, at least one radial protrusion extending away from the central axis, and a notch; and a screw retention mechanism including a flexible member aligned with the notch and attached to either the tip or the shaft. The flexible member has an unattached end which is separated from the second end of the tip. When the tip is inserted into a recess of a screw, the flexible member flexes toward the central axis and creates an opposing elastic force which holds the screw to the tip.

Abstract: A system for affixing a stop plate to an interbody implant. The system includes a clamping device, a stop plate, and an inserter tool. The clamping device includes a body, a first clamping portion attached to the body including a stepped seat and a guide slot, and a second clamping portion attached to the body by a spring. Compressing the spring moves the second clamping portion away from the first clamping portion and expanding the spring moves the second clamping portion toward the first clamping portion.

Abstract: A system for anchoring implants to bones comprises a screw and fixation collar that when connected together inhibit axial movement of the screw and that when connected to an implant with a compatibly shaped aperture inhibit the screw's ability to back out from the bone and back out from the implant. The fixation collar includes a substantially C-shaped configuration partially surrounding a void, with first and second ends defining a gap that is slightly narrower in width than the diameter of the screw and being partially flexible to allow compression and expansion of the fixation collar to snap fit the collar around the screw.

Abstract: Implants for vertebral body or functional spinal unit replacement comprise a bioactive surface roughening on one or more of the anterior, posterior, and lateral surfaces of the implant. The bioactive surface includes macro-, micro-, and nano-scale structural features that contact vertebral bone that lines a specialized channel in a vertebrae, and thereby facilitate bone growth and osteointegration of the implant with the vertebral bone.

Abstract: A system for anchoring implants to bones comprises a screw and fixation collar that when connected together inhibit axial movement of the screw and that when connected to an implant with a compatibly shaped aperture inhibit the screw's ability to back out from the bone and back out from the implant. The fixation collar includes a substantially C-shaped configuration partially surrounding a void, with first and second ends defining a gap that is slightly narrower in width than the diameter of the screw and being partially flexible to allow compression and expansion of the fixation collar to snap fit the collar around the screw.