Abstract: Methods, systems, and software are provided for detecting gene fusions in a subject with a cancer condition through mRNA boundary analysis of next generation sequencing of a transcriptome or relevant part thereof. Methods, systems, and software are provided for detecting splice variants in a subject with a cancer condition through mRNA boundary analysis of next generation sequencing of a transcriptome or relevant part thereof. Methods, systems, and software are provided for evaluating the complexity of an RNA-seq sequencing reaction through mRNA boundary analysis. Generally, the methods described herein include obtaining sequences of mRNA molecules for a plurality of genes in a sample of a subject. For each gene, an RNA boundary distribution including relative abundance value for each respective RNA boundary sub-sequence of the gene is determined from the plurality of sequences. These abundance values are evaluated using one or more models to provide the analyses described herein.

Abstract: A heating element for a vaporizer cartridge is provided. The vaporizer cartridge may include a reservoir containing vaporizable material and a wicking element in fluid communication with the reservoir. The heating element may include a heating portion, a cartridge contact, and a leg. The heating portion includes at least two tines spaced apart from one another. The cartridge contact may be in in electrical communication with a power source. The leg extends between the heating portion and the cartridge contact. The heating portion may be crimped around the wicking element such that the heating portion secures the wicking element to the heating element and contacts at least two surfaces of the wicking element.

Abstract: A CO2 sequestration site is evaluated by incorporating a consistent petrophysical framework having uncertainties expressed in the form of probability density functions of wellbore measurements, by systematically propagating the uncertainties in generating probability density functions or cumulative distribution functions of the parameters used in a reservoir simulation, by using the reservoir simulation to transform the first set of parameters into output variables with uncertainties, and by using the output variables and uncertainties to generate an answer product from which uncertainty levels of performance metrics can be ascertained.

Abstract: An improved regenerative heat exchanger and seal assembly employ a plurality of instances of a seal apparatus, with each seal apparatus including a seal member that includes a seal tab that extends from one end of the seal member and further includes a corresponding notch at the opposite end of the seal member. The seal tab is receivable in a notch of an adjacent seal apparatus, and the engagement of the seal tabs in the notches creates a labyrinth seal by providing a tortuous path that resists the flow of exhaust gases and air past the seal assembly.

Abstract: A CO2 sequestration site is evaluated by incorporating a consistent petrophysical framework having uncertainties expressed in the form of probability density functions of wellbore measurements, by systematically propagating the uncertainties in generating probability density functions or cumulative distribution functions of the parameters used in a reservoir simulation, by using the reservoir simulation to transform the first set of parameters into output variables with uncertainties, and by using the output variables and uncertainties to generate an answer product from which uncertainty levels of performance metrics can be ascertained.

Abstract: A system for delivering tooling around the annulus of a steam generator without damaging any part of the steam generator is provided where the tooling delivery device travels between the tube bundle and the vessel shell and delivers tooling for cleaning, inspection, retrieval and repair. The device has various types of locomotion system including treads, rollers, magnets and vacuum. The cleaning device has multiple high pressure nozzles that rotate 180 degrees about a horizontal axis and 360 degrees about a vertical axis enabling the device to sweep multiple lanes of tubes simultaneously and also clean the front and back of the annulus floor and tube sheet.

Abstract: A system for delivering tooling around the annulus of a steam generator without damaging any part of the steam generator is provided where the tooling delivery device travels between the tube bundle and the vessel shell and delivers tooling for cleaning, inspection, retrieval and repair. The device has various types of locomotion system including treads, rollers, magnets and vacuum. The cleaning device has multiple high pressure nozzles that rotate 180 degrees about a horizontal axis and 360 degrees about a vertical axis enabling the device to sweep multiple lanes of tubes simultaneously and also clean the front and back of the annulus floor and tube sheet.

Abstract: A system is provided for delivering tooling, suction pickup, and alignment platforms to a stay dome region of a stem generator or the tube-free lane regions adjacent to the stay dome region and includes a suction device positioned in the stay dome region of a steam generator capable of rotating 360° about a vertical axis which also acts as a platform for mounting inter-bundle tooling and alignment devices used to position the suction device radially at any given tube location around the stay dome region to align it with an annulus based spray nozzle tube cleaning system.

Abstract: A water-saving diffuser for which a user perceives a relatively higher flow rate than the actual flow rate includes a lower chamber portion housing a distributor disk therein, and an accelerator portion attached to the lower chamber portion, the accelerator portion having a plurality of apertures for producing a multiple-stream output from the water-saving diffuser. A central aperture of the distributor disk can be custom-tailored to produce a specific flow rate for a given water supply pressure. The water-saving diffuser may be used in a water distribution system to provide a predetermined uniform flow rate to all regions of a single- or multi-story building.

Abstract: A variable-demand flow regulator regulates water flow into a building based on variable water supply and variable demand pressures. When water demand increases downstream of the variable-demand flow regulator, the water pressure decreases on the downstream side of the piston valve and a piston of a piston valve moves in the downstream direction. This results in an increased number of access holes being exposed to water flow, thus allowing a higher flow of water when water demand increases. An adjustable bleeder valve controls the flow characteristics of the regulator by affecting the movement of the piston.

Abstract: A water-saving diffuser for which a user perceives a relatively higher flow rate than the actual flow rate includes a hollow barrel for housing an accelerator disk having a plurality of apertures, a distributor disk having a central aperture of a predetermined size, and a chamber ring interposed between the distributor disk and the accelerator disk to define a chamber region therebetween. The central aperture of the distributor disk can be custom-tailored to produce a specific flow rate for a given water supply pressure. The water-saving diffuser may be used in a water distribution system to provide a predetermined uniform flow rate to all regions of a multi-story building.

Abstract: An automatic variable demand flow regulator regulates water flow into a building based on variable supply and demand pressures. The regulator is positioned between a building and a water supply meter for the building. The regulator includes a piston that moves in response to pressure at both the supply side and the demand side of the regulator, and the piston is brought to rest when equilibrium is reached and the supply side and demand side pressures are balanced. When demand is low the piston is in a closed position and flow through the regulator is minimal. When demand increases to a condition where flow through the supply side of the regulator cannot provide equal pressures on both the supply and demand sides, the piston will automatically move toward the demand side to convey additional water to the demand side until the pressures are equalized on both sides of the piston.

Abstract: The invention provides a cloth forming jig for use with a conventional clothing press in the formation of garment parts such as pockets and collars in preparation for their being stitched into position. The jig broadly comprises a base plate formed with a cut-out corresponding in shape to a part to be formed, a forming plate corresponding to said cut-out and pivotal in, and out of, said cut-out, and a forming arm or arms displaceable on said base plate from a position or positions clear of said cut-out to a position or positions overlapping said cut-out.