Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: The present disclosure relates more to mode mixing optical fibers useful, for example in providing optical fiber laser outputs having a desired beam product parameter and beam profile. In one aspect, the disclosure provides a mode mixing optical fiber that includes a core having a refractive index profile; and a cladding disposed about the core. The core of the mode mixing optical fiber supports at least two (e.g., at least five) guided modes at the wavelength. The mode mixing optical fiber is configured to substantially distribute optical radiation having the wavelength propagating therein (e.g., input at its input end or generated or amplified within the core) among a plurality of the guided modes (e.g., to distribute a substantial fraction of the optical radiation having the wavelength propagating therein from its lower-order guided modes to its higher-order guided modes).

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: The present disclosure relates more to mode mixing optical fibers useful, for example in providing optical fiber laser outputs having a desired beam product parameter and beam profile. In one aspect, the disclosure provides a mode mixing optical fiber that includes a core having a refractive index profile; and a cladding disposed about the core. The core of the mode mixing optical fiber supports at least two (e.g., at least five) guided modes at the wavelength. The mode mixing optical fiber is configured to substantially distribute optical radiation having the wavelength propagating therein (e.g., input at its input end or generated or amplified within the core) among a plurality of the guided modes (e.g., to distribute a substantial fraction of the optical radiation having the wavelength propagating therein from its lower-order guided modes to its higher-order guided modes).

Abstract: An integrated electrode structure can comprise a catheter shaft comprising a proximal end and a distal end, the catheter shaft defining a catheter shaft longitudinal axis. A flexible tip portion can be located adjacent to the distal end of the catheter shaft, the flexible tip portion comprising a flexible framework. A plurality of microelectrodes can be disposed on the flexible framework and can form a flexible array of microelectrodes adapted to conform to tissue. A plurality of conductive traces can be disposed on the flexible framework, each of the plurality of conductive traces can be electrically coupled with a respective one of the plurality of microelectrodes.

Abstract: A process for carrying out hematoxylin and eosin staining in a microfluidic device is described.

Abstract: A Mach-Zehnder (MZ) interferometer modulator structure for fiberoptic telecommunications is disclosed in which drift of the operating point can be monitored with a reduced phase tracking error. One or more components of free-space light radiated into the substrate of the MZ modulator are selectively detected with one or more photodetectors. Suitable summing circuits are described for nulling out undesired photocurrent contributions in the photodetector(s) from on-state and off-state light radiated from the MZ.

Abstract: A Mach-Zehnder (MZ) interferometer modulator structure for fiberoptic telecommunications is disclosed in which drift of the operating point can be monitored with a reduced phase tracking error. One or more components of free-space light radiated into the substrate of the MZ modulator are selectively detected with one or more photodetectors. Suitable summing circuits are described for nulling out undesired photocurrent contributions in the photodetector(s) from on-state and off-state light radiated from the MZ.