Patents by Inventor Eric M. JEFFRIES
Eric M. JEFFRIES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938248Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.Type: GrantFiled: August 24, 2020Date of Patent: March 26, 2024Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang, James H. Clampffer
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Patent number: 11857631Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.Type: GrantFiled: November 23, 2021Date of Patent: January 2, 2024Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang, Daniel Long, Noah R. Johnson
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Patent number: 11779647Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.Type: GrantFiled: June 4, 2021Date of Patent: October 10, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang
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Publication number: 20220249672Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.Type: ApplicationFiled: November 23, 2021Publication date: August 11, 2022Inventors: Eric M. Jeffries, Yadong Wang, Daniel Long, Noah R. Johnson
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Patent number: 11298423Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.Type: GrantFiled: March 3, 2017Date of Patent: April 12, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Noah R. Johnson, Daniel Long, Yadong Wang
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Publication number: 20210290770Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.Type: ApplicationFiled: June 4, 2021Publication date: September 23, 2021Inventors: Eric M. Jeffries, Yadong Wang
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Patent number: 11065337Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.Type: GrantFiled: December 14, 2016Date of Patent: July 20, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang
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Publication number: 20200384159Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.Type: ApplicationFiled: August 24, 2020Publication date: December 10, 2020Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang, James H. Clampffer
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Patent number: 10780198Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.Type: GrantFiled: March 6, 2015Date of Patent: September 22, 2020Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang, James H. Clampffer
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Patent number: 10738152Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.Type: GrantFiled: February 26, 2018Date of Patent: August 11, 2020Assignee: Univeristy of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Yadong Wang, Eric M. Jeffries, Robert A. Allen
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Publication number: 20190117780Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.Type: ApplicationFiled: March 3, 2017Publication date: April 25, 2019Inventors: Eric M. Jeffries, Noah R. Johnson, Daniel Long, Yadong Wang
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Publication number: 20180360976Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.Type: ApplicationFiled: December 14, 2016Publication date: December 20, 2018Inventors: Eric M. Jeffries, Yadong Wang
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Publication number: 20180251596Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.Type: ApplicationFiled: February 26, 2018Publication date: September 6, 2018Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Yadong Wang, Eric M. Jeffries, Robert A. Allen
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Patent number: 9938373Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.Type: GrantFiled: December 20, 2013Date of Patent: April 10, 2018Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Yadong Wang, Eric M. Jeffries, Robert A. Allen
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Publication number: 20170072105Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.Type: ApplicationFiled: March 6, 2015Publication date: March 16, 2017Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Eric M. Jeffries, Yadong Wang, James H. Clampffer
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Publication number: 20150322202Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro-or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.Type: ApplicationFiled: December 20, 2013Publication date: November 12, 2015Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Yadong WANG, Eric M. JEFFRIES, Robert A. ALLEN