Patents by Inventor Eric Meggers

Eric Meggers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal complex phosphatidyl-inositol-3-kinase inhibitors
    Patent number: 8106039
    Abstract: Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: January 31, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, The Wistar Institute Of Anatomy And Biology
    Inventors: Eric Meggers, Peng Xie, Douglas S. Williams, Ronen Marmorstein
  • Metal complex glycogen synthase kinase 3 inhibitors
    Patent number: 8080660
    Abstract: The present inventive subject matter relates to novel metal complex glycogen synthase kinase 3 inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by glycogen synthase kinase 3 activity.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: December 20, 2011
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Eric Meggers, Howard Bregman, Douglas S. Williams
  • In vivo incorporation of unnatural amino acids
    Patent number: 7915025
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: March 29, 2011
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • Metal complex protein kinase inhibitors
    Patent number: 7671046
    Abstract: This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: March 2, 2010
    Assignee: The Trustees of the University of Pennyslvania
    Inventors: Eric Meggers, Lilu Zhang
  • In vivo incorporation of unnatural amino acids
    Patent number: 7638300
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: December 29, 2009
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric Meggers, Ryan Aaron Mehl, Miro Pastrnak
  • METAL COMPLEX PHOSPHATIDYL-INOSITOL-3-KINASE INHIBITORS
    Publication number: 20090275547
    Abstract: Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.
    Type: Application
    Filed: April 30, 2008
    Publication date: November 5, 2009
    Inventors: Eric Meggers, Peng Xie, Douglas S. Williams, Ronen Marmorstein
  • Metal complex protein kinase inhibitors
    Patent number: 7488817
    Abstract: This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: February 10, 2009
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Eric Meggers, Lilu Zhang
  • METAL COMPLEX PROTEIN KINASE INHIBITORS
    Publication number: 20080275019
    Abstract: This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.
    Type: Application
    Filed: July 23, 2008
    Publication date: November 6, 2008
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Eric Meggers, Lilu Zhang
  • In vivo incorporation of unnatural amino acids
    Patent number: 7368275
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: May 6, 2008
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric Meggers, Ryan Aaron Mehl, Miro Pastrnak, Steven William Santoro, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20070117184
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 18, 2006
    Publication date: May 24, 2007
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20060233744
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 18, 2005
    Publication date: October 19, 2006
    Inventors: Peter Shultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastmark, Steven Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20060234367
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: October 18, 2005
    Publication date: October 19, 2006
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20060063244
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: December 1, 2004
    Publication date: March 23, 2006
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Metal complex glycogen synthase kinase 3 inhibitors
    Publication number: 20060019942
    Abstract: The present inventive subject matter relates to novel metal complex glycogen synthase kinase 3 inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by glycogen synthase kinase 3 activity.
    Type: Application
    Filed: September 19, 2005
    Publication date: January 26, 2006
    Inventors: Eric Meggers, Howard Bregman, Douglas Williams
  • In vivo incorporation of unnatural amino acids
    Publication number: 20050250183
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: December 17, 2004
    Publication date: November 10, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20050208536
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: December 10, 2004
    Publication date: September 22, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Metal complex protein kinase inhibitors
    Publication number: 20050171076
    Abstract: This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 4, 2005
    Inventors: Eric Meggers, Lilu Zhang