Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: The present invention relates to a nucleic acids and variants thereof, as well as uses thereof. The present nucleic acids are useful for detecting indels (insertions and deletions) as small as 1 nucleotide in a target nucleic acid. They have a broad applicability for detecting indels following genome editing and can also be used in methods for amplifying a target nucleic acid.

Abstract: The display of 3D-representations involves navigation and interaction with users engaged with the display. Points of interest (POIs), as applied to areas of interest for a 3D-representation, are anchored to the 3D-representation on the display and are moveable in synchrony with the 3D-representation navigation. POIs are presented in which interactive actions are associated with the POIs. When a user selects one of the interactive actions associated with a POI, the selection can prompt the display of a new 3D-representation of an item related to the 3D-representation to which the POI is anchored, thereby improving access and analysis about information for related items.

Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: Systems and methods are described for providing an image validation module. The image validation mobile enables capture, enhancement, validation, and upload of a digital image to a networked computing service, applying criteria that correspond to image validation criteria used by the networked computing service. The image validation mobile may be executed on a mobile computing device, and may authenticate itself to the networked computing service to indicate that digital images have already been validated. The image validation module may provide feedback before, during, or after image capture to enable the capture of valid images, and may provide feedback before, during, or after image enhancement to allow issues that prevent a digital image from passing validation to be addressed.

Abstract: The present invention relates to a nucleic acids and variants thereof, as well as uses thereof. The present nucleic acids are useful for detecting indels (insertions and deletions) as small as 1 nucleotide in a target nucleic acid. They have a broad applicability for detecting indels following genome editing and can also be used in methods for amplifying a target nucleic acid.

Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: Systems and methods are described for providing an image validation module. The image validation mobile enables capture, enhancement, validation, and upload of a digital image to a networked computing service, applying criteria that correspond to image validation criteria used by the networked computing service. The image validation mobile may be executed on a mobile computing device, and may authenticate itself to the networked computing service to indicate that digital images have already been validated. The image validation module may provide feedback before, during, or after image capture to enable the capture of valid images, and may provide feedback before, during, or after image enhancement to allow issues that prevent a digital image from passing validation to be addressed.

Abstract: The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

Abstract: The display of 3D-representations involves navigation and interaction with users engaged with the display. Points of interest (POIs), as applied to areas of interest for a 3D-representation, are anchored to the 3D-representation on the display and are moveable in synchrony with the 3D-representation navigation. POIs are presented in which interactive actions are associated with the POIs. When a user selects one of the interactive actions associated with a POI, the selection can prompt the display of a new 3D-representation of an item related to the 3D-representation to which the POI is anchored, thereby improving access and analysis about information for related items.

Abstract: Systems, methods, and computer-readable storage media for enabling immersive, interactive desktop image presentation are provided. Upon receiving a request for presentation of a background image of a search engine home page as a desktop image, the background image is transmitted for presentation on a desktop associated with a computing device. In embodiments, the background image, and likewise the desktop image, permits user interaction therewith. For instance, a user may zoom into the image, pan around the image or otherwise interact with enabled regions of the background and/or desktop image that offer additional content and/or navigate the user to another location where additional information may be found. In this way, the user is provided an immersive, interactive experience with the image whether at the search engine home page, the desktop, or both.

Abstract: Content may be collected, annotated, and propagated in a unified process. In one example, a mobile device such as a smart phone is used to collect information. The information may be text, video, audio, etc. The information may be sent to a reaction service, which may return an annotation of the information. The annotation may be attached to the information to create an annotated document. The annotated document may be communicated to other users. Additionally, the annotated document may be stored in a way that associated the annotated document with the user who created or captured the information. The ability to capture information, obtain annotations to the information, and propagate the annotated information may facilitate the creation of social media, such as social network postings or online photo albums.

Abstract: Systems, methods, and computer-readable storage media for presenting interactive images associated with a search engine in association with a search engine results page (SERP) are provided. Upon receiving a search query at a search engine, it is determined that the search query content has a related interactive image associated with the search engine. An interactive image may be associated with the search engine, for instance, by having been previously presented as a background image for a search engine home page. A link to the interactive image may be presented as a search result on the SERP, the interactive image may be automatically presented as a background image of the SERP, or the interactive image may be determined to be related to an algorithmically-derived search result and a visual indicator thereof may be presented in association with the search result.

Abstract: Systems, methods, and computer-readable storage media for presenting interactive images associated with a search engine in association with a search engine results page (SERP) are provided. Upon receiving a search query at a search engine, it is determined that the search query content has a related interactive image associated with the search engine. An interactive image may be associated with the search engine, for instance, by having been previously presented as a background image for a search engine home page. A link to the interactive image may be presented as a search result on the SERP, the interactive image may be automatically presented as a background image of the SERP, or the interactive image may be determined to be related to an algorithmically-derived search result and a visual indicator thereof may be presented in association with the search result.

Abstract: A digital imaging tool and a method for enhancing, or adjusting, a saturation contrast of a digital image is provided. The digital imaging tool may convert an original color space of a digital image to a second color space having a saturation channel. The digital imaging tool may define a function based, at least partially, on one or more user-provided parameters. Saturation values of pixels of the digital image, in the second color space, may be adjusted, or enhanced, by applying each of the saturation values to the defined function to produce corresponding enhanced saturation values. The second color space then may be converted back to the original color space and a saturation-enhanced version of the digital image may be presented and/or saved.

Abstract: Systems, methods, and computer-readable storage media for enabling immersive, interactive desktop image presentation are provided. Upon receiving a request for presentation of a background image of a search engine home page as a desktop image, the background image is transmitted for presentation on a desktop associated with a computing device. In embodiments, the background image, and likewise the desktop image, permits user interaction therewith. For instance, a user may zoom into the image, pan around the image or otherwise interact with enabled regions of the background and/or desktop image that offer additional content and/or navigate the user to another location where additional information may be found. In this way, the user is provided an immersive, interactive experience with the image whether at the search engine home page, the desktop, or both.

Abstract: Systems, methods, and computer-readable storage media for enabling immersive, interactive search engine home pages are provided. Upon receiving a request for a search engine home page, an image is presented that covers only a portion of the available display. The image includes a portion of a larger image but appears as a complete image. Additional image portions are transmitted for presentation on portions of the display not covered by the first image. Collectively, the image and the additional image portions make up a larger image configured to cover the entire available display. Additionally, portions of the larger image may not be visible on the available display absent some type of user interaction with the larger image. Interactions with the larger image, for instance panning, zooming, and the like are enabled providing the user with an immersive, interactive experience with the search engine home page.

Abstract: An authoring system on a mobile device (or other type of device) may help a user to author a message based on context available on the device. Context data comes to exist on the device in some manner. For example, the context may contain the results of a search that a user has performed on the device. A message may be proposed based on the search query and/or the result—e.g., if a user searches for “Edinburgh,” the authoring system may propose the message “Username likes Edinburgh” or “Username is learning about Edinburgh.” The authoring system may allow the user to change the message and/or to add additional content and/or links to the message. The user may then to send the message over some channel such as e-mail, a social network, a microblogging site, etc.