Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a base, a first paddle, a second paddle, and a rack and pinion mechanism. The first paddle is pivotally connected to the base. The second paddle is pivotally connected to the base. The rack and pinion mechanism is coupled to the first paddle and the second paddle. The rack and pinion mechanism is configured to move the first paddle and the second paddle between an open position and a closed position.

Abstract: A method of identifying and quantifying copy number variations in a gene of interest for a genomic DNA sample includes (i) fragmenting a genomic DNA sample to produce a plurality of polynucleotide fragments, (ii) isolating a plurality of target polynucleotide fragments, (iii) sequencing the plurality of target polynucleotide fragments, (iv) aligning fragment sequences to a reference sequence, (v) calculating read depths for base positions of the plurality of target polynucleotide fragments, (vi) calculating copy number likelihoods for each base position of the reference sequence, (vii) performing a breakpoint analysis on a set of fragment sequences to identify at least one sequence variation located between selected breakpoint regions of the target gene and calculate modified copy number likelihoods for base positions of the reference sequence based on the at least one sequence variation, and (viii) determining whether the target gene includes at least one copy number variation.

Abstract: An assembly includes a dash and a deployable panel supported by the dash. The deployable panel is moveable relative to the dash from an undeployed position to a deployed position. The deployable panel has a proximal end at the dash in the deployed position and a distal end spaced above the dash in the deployed position. An airbag is supported by the dash and is inflatable to an inflated position. The airbag abuts the deployable panel when the deployable panel is in the deployed position and the airbag is in the inflated position. A tether extends from the airbag to the deployable panel in the undeployed position.

Abstract: A valve repair device for repairing a native valve of a patient. The valve repair device includes a paddle, a gripping member, and an indicator. The paddle and/or the gripping member are movable to form an opening or capture region between the gripping member and the paddle. The indicator is configured to indicate whether a leaflet of the native valve is inserted into the opening or capture region between the paddle and the gripping member to at least a minimum insertion depth.

Abstract: A method for manufacturing a biological field-effect transistor (BioFET) is disclosed. In some implementations, the method may include preparing a carbonaceous dispersion by adding a three-dimensional (3D) graphene into a solvent; depositing the carbonaceous dispersion onto a p-type silicon wafer; spin-coating a positive photoresist over the carbonaceous dispersion; forming source and drain terminals on the p-type silicon wafer, the source and drain terminals in contact with the 3D graphene of the carbonaceous dispersion; removing residual photoresist from the carbonaceous dispersion by placing the p-type silicon wafer in 1-methyl-2-pyrrolidone (NMP); and biofunctionalizing the carbonaceous dispersion with a molecular recognition element configured to alter one or more electrical properties of the Bio-FET in response to exposure of the molecular recognition element to the analyte.

Abstract: An on-demand insurance (ODI) server for generating dynamic user offerings may be provided. The ODI server may include at least one processor in communication with a memory device. The at least one processor may be programmed to (i) receive, from a user computing device associated with a user, an insurance policy request for a trip from a start location to an end location, (ii) determine at least one transportation mode available for the trip, (iii) access contextual data associated with the trip, (iv) assess a risk associated with the at least one transportation mode, (v) calculate a risk score associated with the at least one transportation mode based upon at least the contextual data, (vi) generate an insurance offering associated with the at least one transportation mode, and/or (vii) transmit the insurance offering in real time to the user computing device for purchase by the user.

Abstract: The present disclosure relates to a method and audio processing system for performing dynamic range adjustment of spatial audio objects. The method comprises obtaining (step S1) a plurality of spatial audio objects (10), obtaining (step S2) at least one rendered audio presentation of the spatial audio objects (10) and determining (step S3) signal level data associated with each presentation audio channel in said set of presentation audio channels. The method further comprises obtaining (step S31) a threshold value and, for each time segment, selecting (step S4) a selected presentation audio channel which is associated with a highest or a lowest signal level, determining (step S5) a gain based on the threshold value and the representation of the signal level of the selected audio channel, and applying (step S6) the gain of each time segment to corresponding time segments of the spatial audio objects.

Abstract: The present invention is directed to a personal composition comprising a) a strobilurin; b) a 2-pyridinol-N-oxide material wherein the ratio of a:b is from about 10:1 to about 1:20; wherein there is a synergistic anti-inflammatory/cellular stress activity.

Abstract: A system for interference detection includes one or more processors are configured to receive from one or more access points within a wireless network information indicative of airtime usage of one or more client devices associated with the one or more access points, determine an amount of total interference for at least one of the access points on a first channel, the total interference including foreign interference and in-network interference, determine a correlation between the total interference and the airtime usage of the one or more client devices, determine an amount of the foreign interference or an amount of the in-network interference based on the correlation, and selectively switch the at least one of the access points from communicating on the first channel to communicating on a second channel based on the determined amount of the foreign interference or the determined amount of the in-network interference.

Abstract: A system and method to manage charging priority for at least one accessory includes the steps of: providing one or more charging stations for the at least one accessory, monitoring vehicle power status, and monitoring accessory charging status. Additionally, the allocation of power supplied to the one or more charging stations is managed based on priority requirements as determined per each accessory.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: Apparatus for mixing two or more gases prior to entering a reaction chamber, reactor systems including the apparatus, and methods of using the apparatus and systems are disclosed. The systems and methods as described herein can be used to, for example, pulse a mixture of two or more precursors to a reaction chamber.

Abstract: An assembly includes a dash and a deployable panel supported by the dash. The deployable panel is moveable relative to the dash from an undeployed position to a deployed position. The deployable panel has a proximal end at the dash in the deployed position and a distal end spaced above the dash in the deployed position. An airbag is supported by the dash and is inflatable to an inflated position. The airbag abuts the deployable panel when the deployable panel is in the deployed position and the airbag is in the inflated position. A tether extends from the airbag to the deployable panel in the undeployed position.

Abstract: A unified platform may comprise a combination of independent frameworks that have been integrated and configured to collaboratively operate seamlessly. In some aspects, the unified platform may comprise one or more of an authentication and authorization framework, a dynamic user interface framework, a workflow state management framework, a notification and active data loss and prevention (DLP) engine framework, and an orchestration engine framework. Each of the frameworks included in the unified platform may comprise one or more of the plurality of computing devices executing computer-readable program instructions.

Abstract: A parameterized superconducting circuit may include a set of sub-blocks which include superconducting circuitry. Different sub-blocks in the set of sub-blocks may be clocked using clock signals having different phases. Along a first direction, relative locations of the set of sub-blocks may be fixed. Along a second direction, relative locations of the set of sub-blocks may be determined based on a set of parameter values.