Abstract: The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.

Abstract: Disclosed are methods and systems of providing carbon nanotubes decorated with polymer coated metal nanoparticles. Then, annealing the metal coated carbon nanotubes to reduce a quantity of hydrophilic components of the polymer coating.

Abstract: A system of sensor nodes is combined with an RF hub that transmits RF power to the sensors and receives data therefrom. The sensor nodes contain: one or more sensors for measuring indoor conditions, an antenna, an energy storage element, and electronics for powering the system via harvesting RF energy, reading sensor data, and communicating sensor data. The sensors, antenna, and other components on the nodes can be fabricated conventionally, or via printing. They may be fabricated as “flexible hybrid electronics”, in which conventional components are bonded onto flexible substrates. The RF hub consists of one or more antennas capable of transmitting RF power electronics for steering the center of radiation of the RF power in at least one direction or in more than one direction electronics for receiving a demodulating RF data signal. The RF hub may be powered directly from the building.

Abstract: A memory circuit has a ferroelectric memory cell having a word line and a bit line, an input transistor connected to the bit line, a gain element electrically connected the bit line, wherein the gain element includes a feedback capacitor, and an output terminal. A method of reading a memory cell includes applying a voltage to a word line of the memory cell, causing charge to transfer from the memory cell to a feedback capacitor, generating a voltage, amplifying the voltage by applying a gain having a magnitude of less than three, sensing an output voltage at an output node to determine a state of the memory cell, and storing the memory state in a latch.

Abstract: The present disclosure provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: A method for generating a microchannel heat pipe on a substrate surface includes co-extruding a primary material and a secondary material such that the primary material forms side walls that are spaced apart by the secondary material to form a composite structure. After the primary material hardens, the secondary material is removed, whereby the hardened primary material forms a pipe body structure having an elongated central channel defined between opposing end openings. A working fluid is then inserted into the elongated central channel, and sealing structures are then formed over both end openings to encapsulate the working fluid. The co-extrusion process is modified such that the side and upper walls are self-formed either while flowing inside a co-extrusion printhead, or immediately upon exiting the printhead.

Abstract: Printed flexible hybrid electronic systems may require electrical interconnection to peripheral elements. For example, a printed sensor tag with wireless communication may need to connect to a printed sensing electrode on a separated substrate. Frequently, it is desired that these interconnections be detachable in order to replace peripheral elements or to facilitate low cost and simplified assembly, test, rework, and repair. Unlike conventional printed circuit board, mounting a connector on a flexible substrate for detachable connection is challenging due to low temperature requirements. Provide is a teaching of a thin film or form of electrical connection for two circuit elements on separate flexible substrates. The connection is detachable and re-attachable for replacing different circuit elements. The detachable connection is in embodiments realized by selective deposition of fine patterns of conductive materials and non-conductive repositionable pressure-sensitive adhesive.

Abstract: Disclosed herein are embodiments of compositions for gas sensing and sensors utilizing the same. In one embodiment, a composition comprises carbon nanotubes and and polymer-coated metal nanoparticles bound to the carbon nanotubes.

Abstract: A printed resistive gas detector configuration that is simple, inexpensive and compact, fabricated for incorporation into an electronic device, such as an electronic computing and/or communication device, the printed resistive gas detector configuration designed to continuously monitor for predetermined types of gasses. The printed resistive gas detector configuration manufactured by the use of printing technology to print on a flexible substrate.

Abstract: A turbine of a gas turbine engine comprising a stator sealing ring element arranged so as to form a labyrinth sealing joint in combination with at least one wiper, rotatable about the axis of the sealing ring. The element includes an abradable material layer with a surface portion engageable with said movable wiper. The abradable material layer on the surface portion axially includes a first area having a first wiper penetration resistance, said first area corresponding to the axial position of the wiper during nominal operation of the turbine, and a second area adjacent to the first area) and having lower wiper penetration resistance than the first area. The second area is located downstream from the first area and corresponds to the axial position that the wiper takes when a flame goes out in the combustion chamber of the engine.

Abstract: The present disclosure provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: A thin film device has a source region, a drain region, a first gate disposed between the source region and the drain region, a second gate disposed between the source region and the drain region, wherein the second gate region is in close proximity with the first gate region, a semiconductor film disposed between the source region, the drain region, and the first and second gate regions, and a dielectric material disposed between the source region, the drain region, the first and second gate regions, and the semiconductor film.

Abstract: Various systems and methods are provided that retrieve raw data from issuers, reorganize the raw data, analyze the reorganized data to determine whether the risky or malicious activity is occurring, and generate alerts to notify users of possible malicious activity. For example, the raw data is included in a plurality of tables. The system joins one or more tables to reorganize the data using several filtering techniques to reduce the processor load required to perform the join operation. Once the data is reorganized, the system executes one or more rules to analyze the reorganized data. Each rule is associated with a malicious activity. If any of the rules indicate that malicious activity is occurring, the system generates an alert for display to a user in an interactive user interface.

Abstract: A system of sensor nodes is combined with an RF hub that transmits RF power to the sensors and receives data therefrom. The sensor nodes contain: one or more sensors for measuring indoor conditions, an antenna, an energy storage element, and electronics for powering the system via harvesting RF energy, reading sensor data, and communicating sensor data. The sensors, antenna, and other components on the nodes can be fabricated conventionally, or via printing. They may be fabricated as “flexible hybrid electronics”, in which conventional components are bonded onto flexible substrates. The RF hub consists of one or more antennas capable of transmitting RF power electronics for steering the center of radiation of the RF power in at least one direction or in more than one direction electronics for receiving a demodulating RF data signal. The RF hub may be powered directly from the building.

Abstract: A first structure has alternating fingers of first and second materials, the first material having a higher thermal conductivity than the second material, a second structure has alternating fingers of third and fourth materials, positioned to selectively contact the first structure, and an actuator connected to move the second structure. A method of manufacturing a heat switch includes forming a first structure in a first material having finger separated from each other by gaps, forming a second structure in the first material having fingers at least partially separated from each other by gaps, positioning the first and second structure adjacent to and in contact with each other, and connecting the second structure to an actuator. A method of operating includes receiving an activation signal at an actuator, and using the actuator to move one structure relative to another structure to change alignment between two regions of different thermal conductivity.

Abstract: Dye-sensitized ion-pumping membranes and methods of preparing said membranes are described herein. A regenerative and reversible photoactive dye is covalently-bonded to membrane or separator for ion-pumping. The photoactive dye-functionalized membranes can be arranged with other ion-exchange membranes, which serve as selective contacts to afford photovoltaic action and therefore form a power-producing membrane that pumps ions for use in driving an ion-exchange or ion-transport process, such as desalination and electrodialysis.

Abstract: Various systems and methods are provided that retrieve raw data from issuers, reorganize the raw data, analyze the reorganized data to determine whether the risky or malicious activity is occurring, and generate alerts to notify users of possible malicious activity. For example, the raw data is included in a plurality of tables. The system joins one or more tables to reorganize the data using several filtering techniques to reduce the processor load required to perform the join operation. Once the data is reorganized, the system executes one or more rules to analyze the reorganized data. Each rule is associated with a malicious activity. If any of the rules indicate that malicious activity is occurring, the system generates an alert for display to a user in an interactive user interface.

Abstract: The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.

Abstract: A thin film device has a source region, a drain region, a first gate disposed between the source region and the drain region, a second gate disposed between the source region and the drain region, wherein the second gate region is in close proximity with the first gate region, a semiconductor film disposed between the source region, the drain region, and the first and second gate regions, and a dielectric material disposed between the source region, the drain region, the first and second gate regions, and the semiconductor film.

Abstract: A centralized server-based system and method for managing and reserving parking spaces capable of charging an EV, that is, a plug-in hybrid or fully electric vehicle, treats sets of parking spaces as interchangeable pooled resources. An EV motorist can book a reservation with charging of the EV by specifying parking in a desired location. Parking spaces serve dual uses for parking alone or parking with charging. The parking spaces are handled as a common parking pool, such as on one side of a city block, and each space has equal access to a charging station. The server determines charging capacity availability within a time window and the motorist can choose a parking time up to or beyond, if permitted, the maximum charging time needed to charge the EV. Non-EV motorists can similarly reserve parking within a parking pool with the server ensuring optimal use of charging capacity and parking spaces.