Patents by Inventor Eric SHIFRUT

Eric SHIFRUT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20230310502
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: January 27, 2023
    Publication date: October 5, 2023
    Applicant: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • POOLED KNOCK-IN SCREENING AND HETEROLOGOUS POLYPEPTIDES CO-EXPRESSED UNDER THE CONTROL OF ENDOGENOUS LOCI
    Publication number: 20230066806
    Abstract: Provided herein are methods and compositions for identifying a targeted genomic insertion in a cell. Also provided are heterologous polypeptides that are co-expressed under the control of enodogenous loci and methods of using same.
    Type: Application
    Filed: March 13, 2020
    Publication date: March 2, 2023
    Applicant: The Regents of the University of California
    Inventors: Theodore Lee Roth, Po-Yi Jonathan Li, Alexander Marson, Jasper Nies, Cody Mowery, Eric Shifrut, Franziska Blaeschke, Ryan Apathy
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11590171
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: February 28, 2023
    Assignee: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20220241336
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: April 20, 2022
    Publication date: August 4, 2022
    Applicant: Regents of the University of California
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander MARSON, Cristina PUIG SAUS, Antoni RIBAS
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11331346
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: May 17, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20210353678
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: July 30, 2021
    Publication date: November 18, 2021
    Applicant: Regents of the University of California
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander Marson, Cristina PUIG SAUS, Antoni RIBAS
  • COMPOSITIONS AND METHODS FOR MODIFYING REGULATORY T CELLS
    Publication number: 20210340496
    Abstract: Provided herein are compositions and methods for modifying regulatory T cells. The inventors have identified nuclear factors that influence expression of Foxp3, a key transcriptional regulator of Treg cells. Treg cells can be modified by inhibiting and/or overexpressing one or more of these nuclear factors to produce stabilized Treg cells or destabilized Treg cells.
    Type: Application
    Filed: October 10, 2019
    Publication date: November 4, 2021
    Applicant: The Regents of the University of California
    Inventors: Alexander Marson, Jessica T. Cortez, Jeffrey A. Bluestone, Eric Shifrut, Frederic Van Gool
  • GENE TARGETS FOR T-CELL-BASED IMMUNOTHERAPY
    Publication number: 20210317406
    Abstract: Provided herein are genetically modified T cells that exhibit increased proliferation compared to wild-type T cells when stimulated, methods of generating such T cells, and methods of using the T cells for the treatment of a disease such as cancer.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 14, 2021
    Inventors: Alexander MARSON, Eric SHIFRUT, Julia CARNEVALE, Alan ASHWORTH
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11083753
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: August 10, 2021
    Assignee: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20210228631
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 29, 2021
    Inventors: Theodore Lee Roth, Eric SHIFRUT, Alexander MARSON, Cristina PUIG SAUS, Antoni RIBAS
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11033584
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: June 15, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20200000851
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 2, 2020
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander MARSON, Cristina Puig SAUS, Antoni RIBAS
  • T-CELL RECEPTOR CDR3 PEPTIDES AND ANTIBODIES
    Publication number: 20170174764
    Abstract: The present invention provides isolated peptides derived from TCR CDR3 segments, antibodies which recognize them, pharmaceutical compositions comprising them and methods of their use for modulating self-immunity.
    Type: Application
    Filed: March 26, 2015
    Publication date: June 22, 2017
    Inventors: Irun R. COHEN, Nir FRIEDMAN, Asaf MADI, Eric SHIFRUT, Shlomit REICH-ZELIGER, Asaf PORAN