Patents by Inventor Eric Sirota

Eric Sirota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline form of a BACE inhibitor, compositions, and use
    Patent number: 11306080
    Abstract: The present invention provides a novel crystalline form of verubecestat (Crystalline Form II of Verubecestat) and pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease and mild cognitive impairment, are disclosed herein.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: April 19, 2022
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Laura M. Artino, William Morris, Eric Sirota, Richard J. Varsolona
  • A NOVEL CRYSTALLINE FORM OF A BACE INHIBITOR, COMPOSITIONS, AND USE
    Publication number: 20200199117
    Abstract: The present invention provides a novel crystalline form of verubecestat (Crystalline Form II of Verubecestat) and pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an A? pathology and/or a symptom or symptoms thereof. Non-limiting examples of such A? pathologies, including Alzheimer's disease and mild cognitive impairment, are disclosed herein.
    Type: Application
    Filed: June 8, 2018
    Publication date: June 25, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Laura M. Artino, William Morris, Eric Sirota, Richard J. Varsolona
  • Preparation of crystalline forms of dihydropyrazolopyrimidinone
    Patent number: 9388186
    Abstract: The instant invention relates to crystalline forms of MK-1775, an inhibitor of Weel kinase. Specifically, the instant invention relates to hemihydrates of MK-1775.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: July 12, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Rositza Petrova, Eric Sirota, Robert Wenslow
  • PREPARATION OF CRYSTALLINE FORMS OF DIHYDROPYRAZOLOPYRIMIDINONE
    Publication number: 20140187562
    Abstract: The instant invention relates to crystalline forms of MK-1775, an inhibitor of Weel kinase. Specifically, the instant invention relates to hemihydrates of MK-1775.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 3, 2014
    Inventors: Rositza Petrova, Eric Sirota, Robert Wenslow
  • Preparation of crystalline forms of dihydropyrazolopyrimidinone
    Patent number: 8703779
    Abstract: The instant invention relates to crystalline forms of MK-1775, an inhibitor of Weel kinase. Specifically, the instant invention relates to hemihydrates of MK-1775.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: April 22, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Rositza Petrova, Eric Sirota, Robert Wenslow
  • PREPARATION OF CRYSTALLINE FORMS OF DIHYDROPYRAZOLOPYRIMIDINONE
    Publication number: 20120172370
    Abstract: The instant invention relates to crystalline forms of MK-1775, an inhibitor of Weel kinase. Specifically, the instant invention relates to hemihydrates of MK-1775.
    Type: Application
    Filed: September 2, 2010
    Publication date: July 5, 2012
    Inventors: Rositza Petrova, Eric Sirota, Robert Wenslow
  • Paraffinic hydroisomerate as a wax crystal modifier
    Publication number: 20060219597
    Abstract: Heavy fractions of paraffinic lubes produced over dewaxing catalysts are effective as wax crystal modifiers for being hydrocarbons notwithstanding that such heavy fractions have pour points above that of the liquid hydrocarbon.
    Type: Application
    Filed: March 14, 2006
    Publication date: October 5, 2006
    Inventors: Adeana Bishop, Loren Ansell, W. Genetti, Michel Daage, Daniel Ryan, Eric Sirota, Jack Johnson, Patrick Brant
  • Production of extra-heavy lube oils from fischer-tropsch wax
    Publication number: 20060006103
    Abstract: Extra heavy lube base stocks are separated from heavy lube oils with a polar solvent in an amount sufficient to form a first light phase and a second heavy phase. The phases are then separated and the solvent is removed from the second heavy phase to yield an extra heavy lube.
    Type: Application
    Filed: June 17, 2005
    Publication date: January 12, 2006
    Inventors: Eric Sirota, Jack Johnson, Robert Simpson
  • Computer-controlled automated titration apparatus for optically determining incompatibility of petroleum oils
    Publication number: 20050013740
    Abstract: An automatic titration apparatus for optically determining incompatibility of petroleum oils. The apparatus includes reservoirs for oil and solvent, a sealed temperature-controlled mixing vessel, including a liquid mixer, pumps and transfer lines for dispensing oil and solvent from said reservoirs to said mixing vessel wherein oil and solvent are mixed to form a mixture, an aggregate detector, transfer lines for transferring said mixture to the aggregate detector, and a computer programmed to operate and monitor all elements of said apparatus.
    Type: Application
    Filed: June 10, 2004
    Publication date: January 20, 2005
    Inventors: Thomas Mason, Joseph Paszek, Eric Sirota, Mohankumar Sowlay, Lynda Smith, James Sung