Abstract: The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human CD-22. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing CD-22, such as B-cell lymphomas. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. As the transactions are received, the transactions may be analyzed to detect duplicate transactions and/or errors in the transactions. The transaction exchange platform may take steps to remediate transactions that are recognized as duplicates or predicted to generate one or more errors. Similarly, the transaction exchange platform may take steps to remediate transactions that are rejected by a clearinghouse.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. As the transactions are received, the transactions may be analyzed to detect duplicate transactions and/or errors in the transactions. The transaction exchange platform may take steps to remediate transactions that are recognized as duplicates or predicted to generate one or more errors. Similarly, the transaction exchange platform may take steps to remediate transactions that are rejected by a clearinghouse.

Abstract: An electric fillet knife and components thereof. The electric fillet knife includes an electronic switch and a trigger arranged to actuate the electronic switch. The trigger and electronic switch are arranged in a compact configuration permitting reduction of a size of the handle.

Abstract: Techniques are disclosed for advantageously forecasting an inventory of a product having a particular duration (e.g., video content). The technique can include determining the particular configuration (e.g., maximum number of impressions, maximum amount of time permitted) of breaks identified within an impression log. Based on the number of breaks and the configurations of the breaks, the technique can forecast a future inventory of the product. In some implementations, the disclosed technique can identify an amount of a previous break that was not filled with video content. These forecasts can enable product sellers to better communicate with their customers, negotiate supply contracts, price their products, plan for business operations, etc.

Abstract: The protein known as six-transmembrane epithelial antigen of prostate 2 (STEAP2) is highly expressed in prostate cancer and is associated with the expression of other prostate cancer-associated genes. The present invention provides novel full-length human IgG antibodies that bind to human STEAP2 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both STEAP2 and CD3 and activate T cells via the CD3 complex in the presence of STEAP2-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds humanSTEAP2. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing STEAP2.

Abstract: A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

Abstract: A multi-robot system includes a first a mobile cleaning robot that has a local storage device to store a persistent map of an environment, at least one sensor to sense the environment, and a control module. The control module is configured to: control the mobile cleaning robot to navigate in the environment using the persistent map and sensing data provided by the at least one sensor, share the persistent map with a second mobile cleaning robot, and coordinate with the second mobile cleaning robot to perform cleaning tasks.

Abstract: A method for controlling a hydraulic control system that includes a variable pressure relief valve and may include steps for calibrating the hydraulic control system. The hydraulic control system may be calibrated by: controlling, with the controller, the variable pressure relief valve to move to a fully open position, increasing, with the pump, a fluid pressure upstream of the variable pressure relief valve, controlling, with the controller, the variable pressure relief valve to move from the fully open position toward a fully closed position by adjusting a control signal supplied to the variable pressure relief valve, monitoring, with the controller, the pressure detected by the pressure sensor, and recording, with the controller, a parameter of the control signal supplied to the variable pressure relief valve when the pressure detected by the pressure sensor reaches a target pressure.

Abstract: A system and method for determining location information of a portable device relative to an object is provided. In one embodiment, aspects of the system to determine location with respect to the portable device may be distributed among more than one device in the system.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: Soft bait lures emulating a fish are provided. The lure can provide at least one channel within at least one of the exterior surfaces of the tail. Methods for manufacturing a soft bait fishing lure are also provided. The methods can include removing one or more portions of one or more exterior surfaces of the tail to define one or more channels within the one or more surfaces of the tail. Methods for luring fish using a soft bait fishing lure are also provided. The methods can include channeling at least some of the water through one or more channels within the surface of the tail of the fishing lure.

Abstract: Provided herein are processes for recovering lithium ions from a brine source. The process can comprises increasing the pH of a brine source comprising lithium ions to at least about 5.5; contacting the pH-elevated brine source with a bed of protonated ion exchange media to produce a lithiated ion exchange media and a lithium-depleted brine stream; contacting the lithiated ion exchange media with an acidic aqueous wash liquid; and contacting the washed lithiated ion exchange media with an elution liquid comprising an acid. Also provided herein is a process for increasing the pH of brine comprising obtaining brine from a brine source comprising lithium ions; adding the brine to a continuously stirred tank reactor without preprocessing the brine to remove solid matter; adding a strong base to the continuously stirred tank reactor; contacting the brine with the base.

Abstract: This invention relates to compositions of matter, methods, modules and automated, end-to-end closed instruments for automated mammalian cell growth, reagent bundle creation and mammalian cell transfection followed by nucleic acid-guided nuclease editing in live mammalian cells. The disclosed compositions and method entail making “reagent bundles” comprising many (hundreds of thousands to millions) clonal copies of an editing cassette and delivering or co-localizing the reagent bundles with live mammalian cells such that the editing cassettes edit the cells and the edited cells continue to grow.

Abstract: A system and method for determining location information with respect to a portable device and an object. The system and method may be based on UWB communications, and more particularly with respect to a first path power determined with respect the UWB communications. In one embodiment, a differential first path power may be determined based on first and second first path power values obtained respectively by first and second devices via UWB communications with the portable device.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: The present disclosure relates to IL12 receptor agonists with improved therapeutic profiles.

Abstract: The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human PSMA. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing PSMA, such as prostate tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: The present disclosure relates to a fusion protein comprising an antigen-binding moiety that binds specifically to human PD-1 and an IL2 moiety, and methods of use thereof.

Abstract: Geolocating one or more emitters includes obtaining a set of lines of bearing (LOBs) indicative of location(s) of emitter(s), determining intersections of LOBs of the set and generating clusters informed by those intersections, assigning the LOBs of the set to cluster(s) based on proximity, identifying a cluster having the greatest number of assigned LOBs from the set; determining an emitter location area based on a best point estimate for the cluster, and indicating a location of an emitter as the emitter location area. Additional emitters can be located by removing from the set of LOBs those LOBs assigned to the identified cluster, and repeating aforementioned aspects. Initially, the set of LOBs can be selected from a larger collection as a representative subset thereof.