Abstract: The present disclosure relates to a Wingless-type (wnt) inhibitor of formula (I) for use in the treatment of fibrosis and some fibrosis mediated disorders such as stiff skin syndrome and systemic sclerosis. The present disclosure also provides a method for the treatment of fibrosis, a pharmaceutical combination comprising a wnt inhibitor of formula (I) and a second active ingredient for use in the treatment of fibrosis and also the use of a wnt inhibitor of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of fibrosis and fibrosis mediated disorders.

Abstract: The invention relates to a mounting device (1, 1?) for mounting a fork, comprising at least one fork blade (2), on a machine bucket (3), wherein the mounting device (1, 1?) comprises at least one pre-tensioned plate (4) arranged on said at least one fork blade (2), and at least one upper tension stop (6) against which said at least one pre-tensioned pressure plate (4) is pre-tensioned for mounting the machine bucket (3) by clamping the bucket (3) between said at least one pre-tensioned plate (4) and said at least one upper tension stop (6). The invention also relates to a mounting method for mounting a fork (2) on a bucket (3).

Abstract: This invention relates to the use of recombinant adeno-associated virus (rAAV) vectors to transduce cardiomyocytes in vivo by infusing the rAAV into a coronary artery or coronary sinus. rAAV infection is not associated with detectable myocardial inflammation or myocyte necrosis. Thus, rAAV is a useful vector for the stable expression of therapeutic genes in the myocardium and can be used to deliver genes for inducing angiogenesis, inhibiting angiogenesis, stimulating cell proliferation, inhibiting cell proliferation and/or treating or ameliorating other cardiovascular conditions.

Abstract: This invention relates to the use of recombinant adeno-associated virus (rAAV) vectors to transduce cardiomyocytes in vivo by infusing the rAAV into a coronary artery or coronary sinus. rAAV infection is not associated with detectable myocardial inflammation or myocyte necrosis. Thus, rAAV is a useful vector for the stable expression of therapeutic genes in the myocardium and can be used to deliver genes for inducing angiogenesis, inhibiting angiogenesis, stimulating cell proliferation, inhibiting cell proliferation and/or treating or ameliorating other cardiovascular conditions.

Abstract: 3-amino-5-carbonylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

Abstract: A method is disclosed for the treatment of anxiety by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are employed as intermediates in the synthesis of aminochroman compounds useful in the treatment of CNS disorders.

Abstract: A method is disclosed for the treatment of depression by the administration of 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Abstract: A method is disclosed for the treatment of migraine by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.

Abstract: 3-amino-5-aryl- and 5-heteroarylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

Abstract: A brake adjuster for the automatic adjustment of vehicle brakes during the brake application stroke has a lever (13) which is connected to a brake cylinder (2) via a piston rod (1) and, via a slack adjuster (15), is connected to a cam shaft (4) with a brake key (5) for brake application. The slack adjuster (15) cooperates via a one-way clutch (20), a torque limiter (43) and a motion transmitter (28) with a control disc (39) which is fixedly connected to a bearing housing (9) for the cam shaft (4).

Abstract: A dust separation apparatus including a cyclone consisting of three sections, a first cylindrical section provided with a tangentially located inlet duct for dust-loaded waste gases, a second cylindrical section therebelow, and below that a third cone-shaped section. According to the invention, a rotor is located in the second section, which rotor carries outside its periphery one or more emission electrodes. A scraping device is provided outside the rotor to scrape accumulated dust from the inner surface of the second section, which surface acts as a precipitation electrode for dust particles charged by the emission electrode or electrodes.

Abstract: An anchoring device for fence posts, guard-rails, tents, garden greenhouses and the like includes a sleeve which is fluted on its inner side and provided at its bottom with two intersecting arms forming a stop device for the bottom end of the post upon insertion into the sleeve. Furthermore, the sleeve has at its bottom end a cylindrical wall formed with downwardly facing serrations to facilitate rotation of the sleeve into the ground. An anchoring member detachably fixed in the sleeve is bored into the ground for anchoring the anchoring device together with said cylindrical wall.

Abstract: A brake adjuster for the automatic adjustment of vehicle brakes has a lever (13) which is connected to a brake cylinder (2) via a piston rod (1) and which, via a slack adjuster (15), is connected to a cam shaft (4) having a brake key (5) for brake application. The slack adjuster (15) cooperates via a one-way clutch (20) and a motion transmitter (28) with a control disc (39) fixedly attached to a bearing housing (9) for the cam shaft (4). The motion transmitter (28) is formed by a worm wheel (27) which, via said one-way clutch (20), is connected to said slack adjuster (15), and a worm (29) meshing with the worm wheel. The worm (29) is axially movable against the action of a spring (34) upon brake application and is non-rotatably connected to a pinion (31) which is connected to the control disc (39) to transfer the movement thereof, relative to the lever (13 ), to the worm (29).

Abstract: An apparatus for heat treatment of food products, in the form of a product bed consisting of solid particles, includes a container with a perforated bottom for the product bed. Gas is adapted to be supplied to the product bed in the container of this apparatus generally from below upwards through the perforated bottom at such a velocity that the product bed will form a fluidized bed. The gas, which is caused to circulate in the apparatus by means of a fan and to flow through the container as well as through a heat exchanger, is adapted to pulsate through the product bed in the container. According to the invention the apparatus is provided with a conduit passing by the container and being situated before the container with the perforated bottom, as counted in the flow direction, said conduit being provided with a rotatable damper which is adapted during its rotation to raise and lower the pressure under the perforated bottom for the pulsation of the gas through the product bed.

Abstract: A device for transfer of fresh air or air mixed with gases, vapors, smaller particles etc. in one or other direction between a stationary place and a moving place. A stationary elongated box is in communication with the stationary place and has a slot in its longitudinal direction and said slot closeable by a tightening band bearing on contact surfaces at each side of the slot and on the outside of the box. A hollow connection body projects through and is movable along said slot and is in communication with the moving place. Said connection body is provided with slide shoe or shoes in the slot and carries a press roller at each end of the slide shoe or at each slide shoe pressing the band against said contact surfaces and backing rollers lifting the band from engagement with the contact surfaces.