Patents by Inventor Erich Lehr
Erich Lehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050032806Abstract: A method of treating anhedonia in a patient in need thereof, comprising administering to the patient an effective amount of a dopamine agonistType: ApplicationFiled: September 15, 2004Publication date: February 10, 2005Applicant: Boehringer ingelheim pharma GmnH & Co. KGInventors: Erich Lehr, Joachim Mierau, Michael Pieper
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Publication number: 20030036548Abstract: A method of treating anhedonia in a patient in need thereof, comprising administering to the patient an effective amount of a dopamine agonistType: ApplicationFiled: August 6, 2002Publication date: February 20, 2003Applicant: Boehringer Ingelheim Pharma KGInventors: Erich Lehr, Joachim Mierau, Michael P. Pieper
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Patent number: 6492377Abstract: New imidazotriazolopyrimidine derivatives of the formula Preferred are those compounds wherein: R1 denotes methyl, which is optionally substituted by phenyloxy or pyrrole; or R1 denotes benzyl which is optionally substituted by hydroxy, methoxy, dimethylaminoethoxy or fluorine; or R1 denotes cyclopentyl, furan or phenylethyl; R2 or R3 denote ethyl, n-propyl, allyl or propargyl; R4 or R6 denote hydrogen; and, R5 denotes methyl, n-propyl, tert.butyl, cyclopentyl or norbornenyl. These are adenosine antagonists are are useful for, inter alia, the treatment of senile dementia of the Alzheimer's type.Type: GrantFiled: April 26, 2000Date of Patent: December 10, 2002Assignee: Boehringer Ingelheim Pharma KGInventors: Stefan Blech, Adrian Carter, Wolfram Gaida, Matthias Hoffmann, Ulrike Kuefner-Muehl, Christopher John Montague Meade, Gerald Pohl, Werner Kummer, Erich Lehr, Joachim Mierau, Thomas Weiser
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Patent number: 6191153Abstract: The invention relates to the use of pramipexol as a pharmaceutical composition having an antidepressant activity.Type: GrantFiled: March 15, 2000Date of Patent: February 20, 2001Assignee: Boehringer Ingelheim KGInventors: Rudolf Hammer, Joachim Mierau, Erich Lehr, Franco Borsini
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Patent number: 6187780Abstract: Asymmetrically substituted xanthine derivatives having adenosine A1 antagonistic activity. These are useful as pharmaceuticals. Exemplary are: (a) 3-(2-(2-acetyloxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanthine; (b) 3-(2-(hydroxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanthine; and, (c) 3-(2-(carbamoylethyl)-8-(1-noradanantyl)-1-n-propyl-xanthine.Type: GrantFiled: April 7, 1999Date of Patent: February 13, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Stefan Blech, Adrian Carter, Wolfram Gaida, Ursula Gath, Matthias Hoffmann, Ulrike Kuefner-Muehl, Erich Lehr, Joachim Mierau, Gerald Pohl, Thomas Weiser
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Patent number: 5719279Abstract: Xanthine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkynyl,R.sub.2 is different and is alkyl, alkynyl, phenyl-alkylene, phenyl alkenylene, cycloalkyl, inter alia,R.sub.3 is cycloalkyl, phenyl, norbornane, inter alia andR.sub.4 is hydrogen, methyl, benzyl, inter alia.Type: GrantFiled: June 11, 1996Date of Patent: February 17, 1998Assignee: Boehringer Ingelheim KGInventors: Ulrike Kufner-Muhl, Helmut Ensinger, Joachim Mierau, Franz Josef Kuhn, Erich Lehr, Enzio Muller
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Patent number: 5696124Abstract: The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.Type: GrantFiled: May 30, 1995Date of Patent: December 9, 1997Assignee: Boehringer Ingelheim KgInventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Waither, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz Josef Kuhn, Erich Lehr
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Patent number: 5688802Abstract: The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.Type: GrantFiled: June 14, 1996Date of Patent: November 18, 1997Assignee: Boehringer Ingelheim KGInventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Walther, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz Josef Kuhn, Erich Lehr
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Patent number: 5641784Abstract: New xanthine compounds of formula I: ##STR1## wherein the substituents are defined herein, which xanthines are useful as adenosine antagonists.Type: GrantFiled: December 22, 1994Date of Patent: June 24, 1997Assignee: Boehringer Ingelheim KGInventors: Ulrike Kufner-Muhl, Werner Stransky, Gerhard Walther, deceased, Karl-Heinz Weber, Helmut Ensinger, Franz Josef Kuhn, Gunter Schingnitz, Erich Lehr
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Patent number: 5532368Abstract: Xanthines of the formula I ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group:R.sub.2 is a C.sub.1 -C.sub.4 alkyl group;R.sub.3 tetrahydropyran-4-yl or 1,3-dithiolan or;R.sub.3 represents one of the groups of formula ##STR2## and pharmaceutically acceptable acid addition salts thereof. These are adenosine antagonists, capable of acting as cholinomimetics, useful for the treatment of CNS disorders such as senile dementia and Alzheimer's disease.Type: GrantFiled: July 27, 1993Date of Patent: July 2, 1996Assignee: Boehringer Ingelheim GmbHInventors: Ulrike Kufner-Muhl, Karl-Heinz Weber, Gerhard Walther, Werner Stransky, Helmut Ensinger, Gunter Schingnitz, Franz J. Kuhn, Erich Lehr
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Patent number: 5422353Abstract: The invention relates to new tetrahydropyridine derivatives, processes for preparing them and their use as pharmaceutical compositions with cholinomimetic properties.Type: GrantFiled: October 29, 1993Date of Patent: June 6, 1995Assignee: Boehringer Ingelheim KGInventors: Gerhard Walther, Karl-Heinz Weber, Werner Stransky, Franz J. Kuhn, Erich Lehr, Enzio Muller, Gunter Schingnitz, Helmut Ensinger
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Patent number: 5217967Abstract: An improved process for employing tricyclic antidepressants involving co-administration of a N-benzyl-pyrrolidin-2-one.Type: GrantFiled: September 6, 1991Date of Patent: June 8, 1993Assignee: Boehringer Ingelheim GmbHInventors: Erich Lehr, Wolf-Dietrich Bechtel, Astrid Schuster
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Patent number: 5149808Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di-substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; andR.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; orR.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring;where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.Type: GrantFiled: September 4, 1991Date of Patent: September 22, 1992Assignee: Boehringer Ingelheim KGInventors: Karl-Heinz Weber, Gerhard Walther, Claus Schneider, Dieter Hinzen, Franz J. Kuhn, Erich Lehr
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Patent number: 5073671Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di-substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; andR.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; orR.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring;where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.Type: GrantFiled: December 21, 1990Date of Patent: December 17, 1991Assignee: Boehringer Ingelheim KGInventors: Karl-Heinz Weber, Gerhard Walther, Claus Schneider, Dieter Hinzen, Franz J. Kuhn, Erich Lehr
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Patent number: 4996224Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di- substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; andR.sub.3 and R.sub.4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; orR.sub.3 and R.sub.4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring;where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.Type: GrantFiled: May 11, 1989Date of Patent: February 26, 1991Assignee: Boehringer Ingelheim KGInventors: Karl-Heinz Weber, Gerhard Walther, Claus Schneider, Dieter Hinzen, Franz J. Kuhn, Erich Lehr
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Patent number: 4954516Abstract: The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.Type: GrantFiled: July 20, 1989Date of Patent: September 4, 1990Assignee: Boehringer Ingelheim KGInventors: Erich Lehr, Wolf-Dietrich Bechtel, Karin Boke-Kuhn, Claus Schneider, Gerhard Walther, Karl-Heinz Weber
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Patent number: 4931435Abstract: An improved process for employing tricyclic antidepressants involving co-administration of a N-benzyl-pyrrolidin-2-one.Type: GrantFiled: February 26, 1988Date of Patent: June 5, 1990Assignee: Boehringer Ingelheim KGInventor: Erich Lehr
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Patent number: 4912129Abstract: The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.Type: GrantFiled: August 7, 1989Date of Patent: March 27, 1990Assignee: Boehringer Ingelheim GmbHInventors: Erich Lehr, Wolf-Dietrich Bechtel, Karin Boke-Kuhn, Claus Schneider, Gerhard Walther, Karl-Heinz Weber
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Patent number: 4891378Abstract: The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.Type: GrantFiled: June 12, 1989Date of Patent: January 2, 1990Assignee: Boehringer Ingelheim Zentrale GmbHInventors: Karl-Heinz Weber, Claus Schneider, Gerhard Walther, Dieter Hinzen, Franz J. Kuhn, Erich Lehr, Helmut Ensinger, Wolfgang Troger
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Patent number: 4857528Abstract: The invention relates to substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.Type: GrantFiled: April 20, 1988Date of Patent: August 15, 1989Assignee: Boehringer Ingelheim KGInventors: Karl-Heinz Weber, Claus Schneider, Gerhard Walther, Dieter Hinzen, Franz J. Kuhn, Erich Lehr, Helmut Ensinger, Wolfgang Troger