Abstract: A therapeutic device includes a catheter and a temporary vessel occluder. The vessel occluder has a plurality of elastic strands extending in a tubular arrangement from the first end to the second, a primer on the strands, and a polymer filter coating over the primer. The primer is unevenly distributed to the plurality of elastic strands between the plurality of elastic strands. The filter coated is applied over the primer and on the strands. A portion of the polymer coating may be removed.

Abstract: A vascular treatment device for use in a vessel includes a catheter and a microvalve occluder. The occluder includes braided elastic strands, each with a proximal portion, a central portion, and a distal portion, that are fixed to the outer surface of the catheter. The elastic strands. In an embodiment, the distal portions are attached circumferentially about an outer surface of the catheter at a location toward the distal end of the catheter, the central portions extend proximal and radially outward from the distal end, and the proximal portions of the strands are inverted back radially within the central portions are and coupled circumferentially about the outer surface of the catheter at a location proximally displaced from the distal portions. The proximal portion of the microvalve is coated in a fluid-impermeable membrane, and the distal portions of the strands are substantially uncoated.

Abstract: A method of delivering a therapeutic agent into a patient vessel with a delivery device is provided. The delivery device includes an infusion lumen through which the agent is delivered, a vessel occluder that can be operated between a collapsed and an expanded configuration, and when in the expanded configuration occludes the vessel, and a pressure sensor shielded from the effects of turbulent flow at an exit of the infusion lumen. The shield pressure sensor is able to accurately sense pressure in the vessel. The sensed pressure is used to determine a dwell time for the vessel occluder in the expanded configuration.

Abstract: An atraumatic vessel occlusive system includes a flexible tubular member with an infusion lumen, a vessel occluder mounted at the distal end of the tubular member, and a pressure sensor located within a chamber defined by the occluder. The occluder has a braided construct provided with a fluid impermeable membrane over its proximal portion and a fluid permeable covering over its distal portion. The pressure sensor is adapted to sense pressure within the vessel through the fluid permeable membrane without being subject to the effects of turbulent flow at the exit of the infusion lumen. The accurately sensed pressure can be used to determine a dwell time for the occluder.