Patents by Inventor Ernest E. Moore

Ernest E. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent
    Patent number: 11137409
    Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: October 5, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
  • Methodologies and reagents for detecting fibrinolysis and hyperfibrinolysis
    Patent number: 10935559
    Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 2, 2021
    Assignees: Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • COMPOSITIONS AND METHODS FOR WOUND CLOSURE
    Publication number: 20200129448
    Abstract: The current disclosure provides compositions and methods for wound closure. The disclosure provides an device comprising: a) a material with a surface comprising a modified fibrinogen or a modified fibrin, wherein the modified fibrinogen or modified fibrin is more resistant to fibrinolysis than an unmodified fibrinogen or an unmodified fibrin, respectively; and b) one or more dispersible fibrinolysis inhibitors in contact with the surface comprising a plasmin inhibitor; and c) optionally, a thrombin agent or platelets.
    Type: Application
    Filed: July 13, 2018
    Publication date: April 30, 2020
    Inventors: Christopher D. BARRETT, Michael B. YAFFE, Ernest E. MOORE, Hunter B. MOORE, Michael P. CHAPMAN
  • Identification of Novel Disease States Using Viscoelastic Analysis in the Presence of an Thrombolytic Agent
    Publication number: 20170336423
    Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
  • Methodologies and Reagents for Detecting Fibrinolysis and Hyperfibrinolysis
    Publication number: 20160252534
    Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
    Type: Application
    Filed: May 9, 2016
    Publication date: September 1, 2016
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • Methodologies and reagents for detecting fibrinolysis and hyperfibrinolysis in a blood sample using viscoelastic analysis
    Patent number: 9354243
    Abstract: In some embodiments, the invention provides methods for detecting fibrinolysis or hyperfibrinolysis in a blood sample from a patient. The method includes subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the first portion at a time point; and subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at the time point; wherein a difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion indicates fibrinolysis or hyperfibrinolysis in the blood sample.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 31, 2016
    Assignees: Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • Methodologies and Reagents for Detecting Fibrinolysis and Hyperfibrinolysis
    Publication number: 20150316565
    Abstract: In some embodiments, the invention provides methods for detecting fibrinolysis or hyperfibrinolysis in a blood sample from a patient. The method includes subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain the coagulation characteristic of the first portion at the time point; and subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at a time point; wherein a difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion indicates fibrinolysis or hyperfibrinolysis in the blood sample.
    Type: Application
    Filed: May 5, 2014
    Publication date: November 5, 2015
    Applicants: Haemonetics Corporation, The Regents of the University of Colorado
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem