Patents by Inventor Ernst Aufderhaar
Ernst Aufderhaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4847374Abstract: N,N-(dibenzohexatrienylene)urea medicaments can be manufactured in a smooth one-step reaction by reacting a corresponding N,N-(dibenzohexatrienylene)amine with cyanic acid.Type: GrantFiled: January 19, 1988Date of Patent: July 11, 1989Assignee: Ciba-Geigy CorporationInventors: Georg Acklin, Ernst Aufderhaar, Gunter Kaupp, Bernhard Raz, Ulrich Vogel
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Patent number: 4579683Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form.The process is illustrated by the following reaction scheme: ##STR1## The invention relates also to new intermediates produced in these reactions.Type: GrantFiled: February 27, 1984Date of Patent: April 1, 1986Assignee: Ciba-Geigy CorporationInventor: Ernst Aufderhaar
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Patent number: 4559174Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form.The process is illustrated by the following reaction scheme: ##STR1## The invention relates also to new intermediates produced in these reactions.Type: GrantFiled: December 12, 1983Date of Patent: December 17, 1985Assignee: Ciba Geigy CorporationInventor: Ernst Aufderhaar
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Patent number: 4540514Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form.The process is illustrated by the following reaction scheme: ##STR1## The invention relates also to new intermediates produced in these reactions.Type: GrantFiled: February 27, 1984Date of Patent: September 10, 1985Assignee: Ciba-Geigy CorporationInventor: Ernst Aufderhaar
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Patent number: 4452738Abstract: The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example, 5-cyano-5H-dibenz[b,f]azepine of the formula I is nitrated to form 5-cyano-10-nitro-5H-dibenz[b,f]azepine of the formula II, this is subjected to hydrolysis, then reduction, then the reduction product contained in the reaction mixture is subjected to hydrolysis and the end product of the formula III is isolated in pure form.The process is illustrated by the following reaction scheme: ##STR1## The invention relates also to new intermediates produced in these reactions.Type: GrantFiled: May 26, 1983Date of Patent: June 5, 1984Assignee: Ciba-Geigy CorporationInventor: Ernst Aufderhaar
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Patent number: 4436660Abstract: The invention relates to a novel and technically advanced process for producing 5-cyano-5H-dibenz[b,f]azepine by reacting 5H-dibenz[b,f]azepine with a halocyanogen in the presence of strongly polar substances. 5-Cyano-5H-dibenz[b,f]azepine can be used as starting material for producing 5-carbamyl-10(11)-oxo-10,11-dihydro-5H-dibenz[b,f]azepine, which is known to have central-depressant, anticonvulsive and central-muscle-relaxing activity.Type: GrantFiled: May 14, 1982Date of Patent: March 13, 1984Assignee: Ciba-Geigy CorporationInventors: Ernst Aufderhaar, Klemenz Sprecher, Janos Zergenyi
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Patent number: 4205077Abstract: Benzimidazole derivatives of the formula ##STR1## in which R and R.sub.1 independently of one another are each hydrogen, an alkanoyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms, an alkylsulphonyl group having 1 to 4 carbon atoms, a benzoyl group, a phenylsulphonyl group or a p-methylphenylsulphonyl group; R.sub.2 and R.sub.4 independently of one another are each hydrogen, halogen or a methyl group, R.sub.3 is hydrogen, halogen, a methyl group or a methoxy group; X is oxygen or sulphur; Y is halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a methylthio group, a methylsulphinyl group, a methylsulphonyl group, a trifluoromethyl group, a nitro group, a hydroxyl group, a cyano group or an acetyl group; and m is 0, 1, 2 or 3; and if one of the two radicals R or R.sub.1 is hydrogen, the position of the other of these radicals on the N atoms cannot be clearly established, including, when at least one of the two radicals R or R.Type: GrantFiled: April 10, 1978Date of Patent: May 27, 1980Assignee: Ciba-Geigy CorporationInventors: Ernst Aufderhaar, Jean J. Gallay, Manfred Kuhne, Alfred Meyer, Oswald Rechsteiner, Max Schellenbaum, Jean-Paul Fumeaux
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Patent number: 4064265Abstract: The present invention relates to new dithiocarbamic acid esters having the formula ##STR1## wherein R.sub.1 represents a phenyloxyphenyl or phenylaminophenyl radical which is unsubstituted or substituted by lower alkyl, halogen, trifluoromethyl, nitro or cyano, R.sub.2 represents hydrogen or lower alkyl, and alk represents lower alkylidene or lower alkylene, and also to salts of compounds of the formula (I), wherein R.sub.2 represents hydrogen, with pharmaceutically acceptable bases. These new compounds possess a strong anthelminthic activity and are useful for the treatment of warm-blooded animals infected with parasitic helminths. A specific embodiment is the N-[4-(4-nitroanilino)-phenyl]-dithiocarbamic acid-(2-carboxyethyl)-ester.Type: GrantFiled: June 23, 1976Date of Patent: December 20, 1977Assignee: Ciba-Geigy CorporationInventors: Denis V. Varsanyi, Ernst Aufderhaar, Ernst Schweizer
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Patent number: 4035423Abstract: A new process for the production of 3,4-dialkoxyanilines in which the two alkyl groups are different from each other is disclosed. The process comprises the stepwise introduction of the alkyl groups in different stages of the process by converting pyrocatechol into its monoalkyl ether, coupling said monoalkyl ether with a phenyldiazonium salt, alkylating the 3-alkoxy-4-hydroxy-azobenzene obtained to form 3,4-dialkoxyazobenzene and reductively cleaving the latter to the corresponding 3,4-dialkoxyaniline. The 3,4-dialkoxyanilines obtainable by the new process are valuable intermediates for the preparation of 4-hydroxy-6,7-dialkoxy-3-quinoline carboxylic acid esters which are excellent coccidiostats.Type: GrantFiled: February 20, 1976Date of Patent: July 12, 1977Assignee: Ciba-Geigy CorporationInventors: Jean-Jacques Gallay, Ernst Aufderhaar, Peter Labuhn
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Patent number: 3987181Abstract: Process for the control of parasitic helminths by the use of 2-trifluoromethyl-benzimidazole derivatives of formula I ##SPC1##whereinR.sub.1 represents halogen or a haloalkyl radical,R.sub.2 represents halogen, an alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, alkenylthio, alkylsulphinyl, alkylsulphonyl, alkenylsulphinyl or alkenylsulphonyl radical,R.sub.3 represents halogen,X represents oxygen, sulphur, sulphinyl or sulphonyl,m represents an integer from 0 to 3,n represents an integer from 0 to 2,p represents an integer from 0 to 3,And salts thereof with inorganic or organic bases, and anthelmintic compositions containing a compound of the above formulae or a salt thereof.Type: GrantFiled: January 17, 1975Date of Patent: October 19, 1976Assignee: Ciba-Geigy CorporationInventors: Walter Traber, Ernst Aufderhaar