Abstract: Systems and methods for making and using endoscopes comprising one or more fluid lenses. An endoscope or bore-scope for various highly accurate imaging, visual inspection and measurement applications is equipped with an adaptive lens operated based on the electrowetting or electro-capillarity phenomenon. The adaptive lens is digitally controlled and is able to provide auto-focusing and optical zooming functions while remaining in a stationary position relative to a distal end section of the endoscope. Endoscopes equipped with these adaptive lenses provide a simpler, more compact design and a faster response while providing high quality images. Several functions needed in a variety of endoscopic imaging, inspection and measurement applications are further enhanced through the addition of a number of improvements of the adaptive lens itself and of the systems incorporating the adaptive lens.