Abstract: A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit.

Abstract: A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI).

Abstract: Method for determining anesthesia dosage includes following steps. First Interventional Agent (“FIA”) is administered to Patient at a first rate to achieve First Predetermined Plane of Anesthesia (“FPPA”). Brain waves of Patient are analyzed to formulate First Set of Data (“FSD”) corresponding to a self-norm during administration of FIA. First transfer function corresponding to patient biochemical reactions to FIA is computed from FSD. Rate of administration of FIA to Patient is altered by a selected amount after achievement of FPPA for first time required for Patient to deviate from FPPA by predetermined degree. An altered amount of FIA required to cause the predetermined deviation is determined as difference between amount of FIA that would have been delivered to Patient during first time at the first rate and an amount delivered to Patient during the first time at the altered rate. Patient is administered the altered amount of FIA.

Abstract: A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit.

Abstract: An osmotic pump includes a plurality of agent reservoirs; first and second solute chambers; a semi-permeable membrane separating the first and second solute chambers from one another; a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and a plurality of valves. Each of the valves is moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet.

Abstract: Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories.

Abstract: An osmotic pump includes a plurality of agent reservoirs; first and second solute chambers; a semi-permeable membrane separating the first and second solute chambers from one another; a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and a plurality of valves. Each of the valves is moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet.

Abstract: A system for treating a disorder of a central nervous system (CNS) comprises first and second conduits, distal ends of which are open to a patient's cerebrospinal fluid (CSF). A proximal end of the second conduit opens to drain CSF from the CNS. A first implantable reservoir holds a first material to be introduced to the CNS. An intracranial pressure detecting unit includes a transmitter for providing auditory signals to the patient and a BAUR analyzer for analyzing brainstem evoked auditory potentials to determine current intracranial pressure. A pump is coupled to the first reservoir and introduces the first material to the CNS via the first conduit. A brain activity detection unit delects and analyzes brain activity of the patient and controls drainage of CSF based on input from the intracranial pressure detecting unit to maintain intracranial pressure within a predetermined range.

Abstract: A system and method for analyzing electrophysical signals produced by a brain involves comparing a first selected one of the numerical values to control data including one of a self-norm and a population-norm associated with electrophysical activity in a brain region corresponding to a brain region of origin of the electrophysical activity on which the numerical value is based; calculating a standard score for the brain region of origin based on the comparing; and repeating the comparing and calculating operations for a second selected one of the numerical values, the regions of the brain including subcortical regions extending to a brain stem of the brain.

Abstract: Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories.

Abstract: Data corresponding to brain electrical activity of a patient from a QEEG is processed to determine which brain activity data deviates from that of a normative profile. The deviant brain activity data is used to determine a brain state vector (BSV) in a multidimensional brain electrical signal space, wherein the orientation of the BSV indicates the nature of the deviation from a normal state and may be used to prescribe a medicine to the patient and wherein the length of the BSV quantifies the degree of abnormality exhibited by the patient and may indicate the dosage of the medicine to be prescribed to the patient.

Abstract: A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.

Abstract: A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.

Abstract: A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit.

Abstract: Described is a system and method which includes the following steps. A plurality of interventional agents are administered to a patient until the patient attains a predetermined plane of anesthesia. Brain waves of the patient are amplified and digitized before and after the administering step to generate a first set of digital data. The brain waves of the patient are amplified and digitized during a medical procedure to generate a second set of digital data. Separate trajectories for at least two different indices of an anesthetic state of the patient are computed during the medical procedure as a function of a comparison of the first and second sets of digital data. The indices include a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI). The DI corresponds to a depth of anesthesia of the patient, the PI corresponds to a sensitivity of the patient to pain and the MI corresponds to an ability of the patient to form and store memories.

Abstract: A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit.

Abstract: A system, comprises a plurality of neurometric analyzing software modules operating on electroencephalogram (EEG) data, each module performing a defined task with respect to neurometric analysis of the EEG data and a database including normative neurometric data in combination with a server including an authorization module, the authorization module comparing data received from a remote user to determine whether the user is authorized to utilize any of the plurality of analyzing software modules and an analysis module configured to receive input data from a patient and select one of the neurometric analyzing modules based on the input data, wherein the selected one of the neurometric analyzing modules compares the input data to the normative neurometric data to generate an output, the analysis module selecting the one of neurometric analyzing modules from a set of subscribed neurometric analyzing modules.

Abstract: A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI).

Abstract: A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI).

Abstract: In a computer based system and method for behavior testing of human subjects, the subject is simultaneously presented with stimuli in two modes, for example, a screen showing a moving target spot and a subject controlled pursuer, and also a tone which varies in pitch and changes in amplitude as between left and right earphones. In one embodiment, the subject's brain waves are detected and measured, using an electroencephalograph (EEG) instrument, at the same time the subject is performing the test.