Patents by Inventor Eszter Boros

Eszter Boros has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZAMACROCYCLE-DERIVED CHELATOR COMPOSITIONS FOR COORDINATION OF IMAGING AND THERAPY METAL IONS AND METHODS OF USING SAME
    Publication number: 20210276971
    Abstract: The present invention provides a compound having the structure: and methods of using the compound in targeted PET imaging.
    Type: Application
    Filed: June 20, 2019
    Publication date: September 9, 2021
    Applicant: The Research Foundation for The State University of New York
    Inventors: Eszter Boros, Brett Vaughn
  • PEPTIDIC STRUCTURES INCORPORATING AN AMINO ACID METAL COMPLEX AND APPLICATIONS IN MAGNETIC RESONANCE IMAGING
    Publication number: 20150297761
    Abstract: A method for increasing the relaxivity of a contrast agent having a metal ion complexed to a chelator is disclosed. The metal ion complex is tethered to the remainder of the molecule by at least two points of attachment such that local motion is limited and higher relaxivity can be achieved. In one non-limiting example version of the invention, the alanine analogue of Gd(DOTA), Gd(DOTAla) wherein Gd is gadolinium and DOTA is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid was integrated into polypeptide structures. This resulted in very rigid attachment of the metal ion complex to the peptide backbone. Rigid molecular structures provide fewer degrees of rotational freedom, resulting in greater control over the rotational dynamics and resultant relaxivity. In the case of Gd(DOTAla), the metal complex is tethered to the peptide via the amino acid side chain to the DOTA moiety and via a dative bond from an amide oxygen to the Gd(III) ion.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 22, 2015
    Inventors: Peter Caravan, Eszter Boros, Eric M. Gale
  • Bifunctional chelating agents
    Patent number: 8772446
    Abstract: A bifunctional chelating agent of the formula (I): wherein the variables R1, R1?, Q1, Q2 and M are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a stable or radioactive metal; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: July 8, 2014
    Assignee: Nordion (Canada) Inc.
    Inventors: Mike Adam, Eszter Boros, Cara L. Ferreira, Chris Orvig, Eric William Price
  • BIFUNCTIONAL CHELATING AGENTS
    Publication number: 20110313130
    Abstract: A bifunctional chelating agent of the formula (I): wherein the variables R1, R1?, Q1, Q2 and M are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a stable or radioactive metal; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 22, 2011
    Inventors: Mike ADAM, Eszter Boros, Cara L. Ferreira, Chris Orvig, Eric William Price