Abstract: The present invention is directed to a composition including 1-15% by weight pro-Lycopene, and methods of using same, such as for preventing or treating an oxidative stress related condition.

Abstract: The present invention is directed to a composition comprising a cannabinoid and lycopene, kits comprising same, and methods of using same, such as for treating a subject afflicted with inflammation.

Abstract: The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.

Abstract: The present invention provides methods for deriving oligonucleotides for specific internal delivery to one or more target cell types (e.g., cancer cells). The method generally includes selecting at least once with a target cell type to provide a plurality of internalizing oligonucleotides for the target cell type, and in some embodiments, counter-selecting at least once with a non-target cell type to provide a plurality of oligonucleotides that do not bind to features present in the non-target cell type. Therapeutic and diagnostic compositions including the oligonucleotides, and methods of treatment are also provided.

Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

Abstract: This invention relates to the identification of genes linked to hair loss and the retardation of hair growth. In one embodiment, the invention relates to the identification of a gene, a mutation of which plays a role in the onset of a nonsyndromic alopecia, such as hytrichosis simplex of the scalp (HSS). More particularly, it relates to the corneodesmosin (CDSN) gene, which encodes the protein known as corneodesmosin.