Patents by Inventor Etsuo Ohshima
Etsuo Ohshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082194Abstract: The present invention exhibits strong preventive effects and/or therapeutic effects with regard to inflammatory disorders and/or pain disorders by combining and administering glutathione trisulfide or a pharmaceutically-acceptable salt thereof and a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 7, 2022Publication date: March 14, 2024Applicant: Kyowa Pharma Chemical Co., Ltd.Inventor: Etsuo OHSHIMA
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Publication number: 20230357141Abstract: A compound represented by Formula (1) below or a salt thereof.Type: ApplicationFiled: August 23, 2021Publication date: November 9, 2023Applicant: Kyowa Pharma Chemical Co., Ltd.Inventors: Shoichiro TOMONAGA, Takahiro ISOBE, Etsuo OHSHIMA
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Publication number: 20230331692Abstract: A compound represented by Formula (1) or (3). wherein R1 and R2 are each independently a hydrogen atom; a C1-6 alkyl group optionally having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11; or —(CH2CH2O)nR8; wherein R4 is a C1-6 alkyl group having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11, or —(CH2CH2O)nR8; wherein R5, R6, R7, R8, R9, R10 and R11 are each independently a hydrogen atom or a C1-3 alkyl group; and n is an integer of 2 to 5.Type: ApplicationFiled: August 25, 2021Publication date: October 19, 2023Applicant: Kyowa Pharma Chemical Co., Ltd.Inventors: Shoichiro TOMONAGA, Takahiro ISOBE, Etsuo OHSHIMA
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Patent number: 9663537Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: GrantFiled: March 10, 2015Date of Patent: May 30, 2017Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20160031908Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: March 10, 2015Publication date: February 4, 2016Inventors: Jay R. LULY, Yoshisuke NAKASATO, Etsuo OHSHIMA, Geraldine C.B. HARRIMAN, Kenneth G. CARSON, Shomir GHOSH, Amy M. ELDER, Karen M. MATTIA
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Publication number: 20140371207Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: December 13, 2013Publication date: December 18, 2014Applicants: Kyowa Hakko Kirin Co., Ltd., Millennium Pharmaceuticals, Inc.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C.B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Patent number: 8653096Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: GrantFiled: September 26, 2011Date of Patent: February 18, 2014Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Patent number: 8192736Abstract: The present invention provides a therapeutic agent for endometriosis comprising an interleukin-5 antagonist as an active ingredient.Type: GrantFiled: October 28, 2005Date of Patent: June 5, 2012Assignee: Kyowa Hakko Kirin Co., LtdInventors: Etsuo Ohshima, Hirokazu Kawasaki, Naoya Kimoto, Akihiko Watanabe
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Publication number: 20120046311Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: September 26, 2011Publication date: February 23, 2012Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Patent number: 8058287Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: GrantFiled: May 6, 2009Date of Patent: November 15, 2011Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20090281081Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: May 6, 2009Publication date: November 12, 2009Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20090252723Abstract: The present invention provides a therapeutic agent for endometriosis comprising an interleukin-5 antagonist as an active ingredient.Type: ApplicationFiled: October 28, 2005Publication date: October 8, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD>Inventors: Etsuo Ohshima, Hirokazu Kawasaki, Naoya Kimoto, Akihiko Watanabe
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Patent number: 7541365Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: GrantFiled: November 10, 2006Date of Patent: June 2, 2009Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Patent number: 7524852Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.Type: GrantFiled: June 6, 2003Date of Patent: April 28, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Tsutomu Matsumura, Hiroshi Ishida, Yosuke Yamaura, Seiji Aratake, Etsuo Ohshima, Koji Yanagawa, Motoki Miyama, Koji Suzuki, Ari Kawabe, Satoshi Nakanishi, Katsuya Kobayashi, Takashi Sato, Ichiro Miki, Kimihisa Ueno, Shinya Fujii, Miho Iwase
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Publication number: 20080085858Abstract: The present invention provides a pharmaceutical composition comprising (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, a therapeutic and/or preventive agent for chronic skin diseases comprising (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, a therapeutic and/or preventive agent for chronic skin diseases to be administered simultaneously or separately with an interval comprising (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, as active ingredients; and the like.Type: ApplicationFiled: October 13, 2005Publication date: April 10, 2008Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Daisuke Harada, Katsuya Kobayashi, Haruhiko Manabe, Etsuo Ohshima
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Publication number: 20070287689Abstract: The present invention provides: a therapeutic and/or preventive agent for chronic skin diseases which comprises (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a steroid agent as active ingredients; a therapeutic and/or preventive agent for chronic skin diseases to be administered simultaneously or separately with an interval which comprises (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a steroid agent, as active ingredients; a kit for treating and/or preventing chronic skin diseases characterized by comprising (a) a first component comprising a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a second component comprising a steroid agent; and the like.Type: ApplicationFiled: October 13, 2005Publication date: December 13, 2007Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Daisuke Harada, Katsuya Kobayashi, Haruhiko Manabe, Etsuo Ohshima
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Patent number: 7271176Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.Type: GrantFiled: November 13, 2002Date of Patent: September 18, 2007Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20070060592Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.Type: ApplicationFiled: November 10, 2006Publication date: March 15, 2007Inventors: Jay Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine Harriman, Kenneth Carson, Shomir Ghosh, Amy Elder, Karen Mattia
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Patent number: 7186729Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.Type: GrantFiled: November 13, 2002Date of Patent: March 6, 2007Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
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Publication number: 20070037834Abstract: [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(?O)—, —SO2—, —OC(?O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided.Type: ApplicationFiled: June 6, 2003Publication date: February 15, 2007Inventors: Hitoshi Arai, Tsutomu Matsumura, Hiroshi Ishida, Yosuke Yamaura, Seiji Aratake, Etsuo Ohshima, Koji Yanagawa, Motoki Miyama, Koji Suzuki, Ari Kawabe, Satoshi Nakanishi, Katsuya Kobayashi, Takashi Sato, Ichiro Miki, Kimihisa Ueno, Shinya Fujii, Miho Iwase