Abstract: The present invention provides microfluidic devices capable of sequestering single particles in individual microchambers and isolating the particles from one another. The devices provide a plurality of channels fluidly connected to a plurality of microchambers. A fluid suspension comprising particles of interest can be passed through the devices in a first direction to sequester single particles in each microchamber. An isolating fluid can be passed through the devices in a second, reverse direction to isolate the particles from one another. The devices can selectively isolate several particles in each microchamber.

Abstract: This invention relates to the use of angiotensin II antagonists in treating or preventing the development of disease conditions associated with impaired neuronal conduction velocity, such as diabetic neuropathy, as well as their use in the manufacture of a medicament for use in such treatment. The invention also concerns pharmaceutical compositions containing an angiotensin II antagonist together with one or more other agents known to be of value in treating or preventing the development of disease conditions associated with impaired neuronal conduction velocity.

Abstract: The invention relates to pharmaceutical compositions comprising an aldose reductase inhibitor and an ACE inhibitor, and their use in the treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy and diabetic nephropathy.

Abstract: A system for precisely determining the location of a cursor on a work surface with respect to a grid of coordinate conductors. The system is based on the time-distance relationship of current sheets caused to move sequentially along each axis of the work surface, and the detection of each current sheet as it approaches and passes an operator-movable sensor. A number of the grid wires are simultaneously energized with a fixed energization pattern which steps along the conductors, thereby generating the current sheet and consequent magnetic field which translate along the plane of the conductors parallel to the conductors. A preferred means responsive to the time of passage of the current sheet comprises an inductive pickup coil having a diameter approximately equal to the width of the current sheet and means for sensing current induced in the pickup coil. Preferably, the grid conductors are energized with substantially fixed constant currents.