Patents by Inventor Eugene A. Davidson

Eugene A. Davidson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9638702
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: May 2, 2017
    Assignee: SYSTEM OF SYSTEMS ANALYTICS, INC.
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Patent number: 9562258
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: February 7, 2017
    Assignee: Georgetown University
    Inventors: Mark Danielsen, Joel Credle, Eugene A. Davidson, Kenneth L. Dretchen
  • Publication number: 20150233948
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 20, 2015
    Applicant: Adlyfe, Inc.
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Patent number: 9012142
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: April 21, 2015
    Assignee: Georgetown University
    Inventors: Mark Danielsen, Eugene A. Davidson, Kenneth L. Dretchen, Traci K. Pals
  • Publication number: 20140256577
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Application
    Filed: February 3, 2014
    Publication date: September 11, 2014
    Applicant: Georgetown University
    Inventors: Mark DANIELSEN, Joel Credle, Eugene A. Davidson, Kenneth L. Dretchen
  • Publication number: 20120065088
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Application
    Filed: February 23, 2010
    Publication date: March 15, 2012
    Applicant: Georgetown University
    Inventors: Mark Danielsen, Joel Credle, Eugene A. Davidson, Kenneth L. Dretchen
  • Patent number: 8062895
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: November 22, 2011
    Assignee: Adlyfe, Inc.
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Publication number: 20110123980
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Application
    Filed: February 15, 2006
    Publication date: May 26, 2011
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Mark Danielsen, Eugene A. Davidson, Kenneth L. Dretchen, Traci L. Pals
  • Publication number: 20100267151
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    Type: Application
    Filed: March 18, 2010
    Publication date: October 21, 2010
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Patent number: 7691639
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: April 6, 2010
    Assignee: Adlyfe, Inc.
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Publication number: 20080171341
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 17, 2008
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Patent number: 7166471
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: January 23, 2007
    Assignee: Arete Associates
    Inventors: Cindy Orser, Anne Grosset, Eugene A Davidson
  • Publication number: 20060286672
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
    Type: Application
    Filed: May 30, 2002
    Publication date: December 21, 2006
    Inventors: Cindy Orser, Anne Grosset, Eugene Davidson
  • Publication number: 20060275910
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Inventors: Cindy Orser, Anne Grosset, Eugene Davidson
  • Publication number: 20050026165
    Abstract: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
    Type: Application
    Filed: December 4, 2003
    Publication date: February 3, 2005
    Inventors: Cindy Orser, Anne Grosset, Eugene Davidson
  • Publication number: 20030104633
    Abstract: A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
    Type: Application
    Filed: May 30, 2002
    Publication date: June 5, 2003
    Inventors: Cindy Orser, Anne Grosset, Eugene A. Davidson
  • Patent number: 6551586
    Abstract: The present invention relates to an expression vector which expresses a malaria MSA1 peptide in combination with a signal peptide and anchor peptide in a host animal. The MSA1 peptide is combined with a signal peptide and anchor peptide for expression. Chimeric peptides being expressed with both signal peptides and anchor peptides were the most effective in eliciting an immunogenic response from a vaccinated host.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: April 22, 2003
    Assignee: Georgetown University
    Inventors: Eugene A. Davidson, Shutong Yang
  • Patent number: 5808074
    Abstract: A benzoylecgonine conjugate represented by the following formula: ##STR1## wherein, R is H or CH.sub.3 ; R' is --NH--NH--, --(NH).sub.2 --CO--(CH.sub.2).sub.n --CO--NH--NH--, or related linear chains wherein at least one (CH.sub.2) is replaced with a substituent selected from the group consisting of an ether, an amide, a sulfide, a disulfide, an alkyl, an aryl, an alkoxy, an aryloxy or an alkylhalide; and T is a targeting substance selected from the group consisting of proteins, peptides, antigens, polypeptides, dyes, biotins, enzymes, antibodies, hormones, carbohydrates, polysaccharide supports, and filter paper.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 15, 1998
    Assignee: Georgetown University
    Inventors: D. Channe Gowda, Eugene A. Davidson
  • Patent number: D391546
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: March 3, 1998
    Inventors: Thomas H. Frink, Darrin Eugene Davidson
  • Patent number: RE36064
    Abstract: There is disclosed, in one aspect, chlorous acid generating compositions useful for disinfecting substrates. The compositions comprise aqueous solutions containing a suitable amount of a protic acid, such as citric or malic acid, and a suitable amount of a metal chlorite, such as sodium chlorite. The chlorite ion concentration which is in the form of chlorous acid in the composition is no more than about 15 percent by weight of the total amount of chlorite ion concentration. In a preferred embodiment, the composition also contains a vicinal dihydroxy or polyhydroxy compound. In another preferred embodiment, the composition contains at least a 10-fold molar excess of a water soluble chloride ion compared to the total concentration of chlorite ion. In another aspect, there is disclosed a process for disinfecting substrates. This process comprises applying the compositions described above to a substrate. In yet another aspect, there is disclosed a process for preparing the compositions described above.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: January 26, 1999
    Assignee: Alcide Corporation
    Inventors: Eugene A. Davidson, Robert D. Kross