Abstract: A multi-stage transimpedance amplifier (TIA) with an adjustable input linear range is disclosed. The TIA includes a first stage, configured to convert a single-ended current signal from an optical sensor of a receiver signal chain to a single-ended voltage signal, and a second stage, configured to convert the single-ended voltage signal provided by the first stage to a differential signal. In such a TIA, the input linear range may be adjusted using a clamp that is programmable with an output offset current to keep the second stage of the TIA from overloading and to maintain a linear transfer function without compression.

Abstract: Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

Abstract: The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.

Abstract: Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

Abstract: Differential clamp circuits configured to recirculate the current in one clamp, either low-side clamp or high-side clamp, from one output of a differential signal to the other output of the differential signal are disclosed. Differential clamp circuits described herein may be particularly suitable for providing programmable clamps at differential outputs of an ADC driver and may be particularly beneficial to implement clamps that are symmetrical around an ADC's input common-mode voltage. Some differential clamp circuit described herein may advantageously present a smaller capacitive load at each output, thus reducing bandwidth degradation of the output stage. Furthermore, differential clamp circuits described herein may operate with only one control voltage, making it easier to limit the output excursions symmetrically around the default common-mode voltage.

Abstract: A multi-stage transimpedance amplifier (TIA) with an adjustable input linear range is disclosed. The TIA includes a first stage, configured to convert a single-ended current signal from an optical sensor of a receiver signal chain to a single-ended voltage signal, and a second stage, configured to convert the single-ended voltage signal provided by the first stage to a differential signal. In such a TIA, the input linear range may be adjusted using a clamp that is programmable with an output offset current to keep the second stage of the TIA from overloading and to maintain a linear transfer function without compression.

Abstract: Differential clamp circuits configured to recirculate the current in one clamp, either low-side clamp or high-side clamp, from one output of a differential signal to the other output of the differential signal are disclosed. Differential clamp circuits described herein may be particularly suitable for providing programmable clamps at differential outputs of an ADC driver and may be particularly beneficial to implement clamps that are symmetrical around an ADC's input common-mode voltage. Some differential clamp circuit described herein may advantageously present a smaller capacitive load at each output, thus reducing bandwidth degradation of the output stage. Furthermore, differential clamp circuits described herein may operate with only one control voltage, making it easier to limit the output excursions symmetrically around the default common-mode voltage.

Abstract: Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.

Abstract: An analog control circuit is coupled to an apparatus having a variable characteristic over an operating range. A sensing circuit is coupled to the apparatus and the control circuit during the range of operation of the apparatus and is operative to sense the variable characteristic. The operating parameter of the apparatus is controlled to be set at a level corresponding to a prescribed criterion, which may be a maximum or minimum, of the characteristic sensed over the range of operation.

Abstract: Pulse width modulation of the connection of a load output terminal to a power supply terminal is effected. In response to a first level of the pulse width modulated signal, the load is disconnected from the power supply terminal, steady-state load voltage is preserved on a capacitor connected between a load output terminal and a power supply terminal, and steady-state load current information is held on a capacitor within the feedback loop. In response to a second level of the pulse width modulated signal, the load is reconnected to the power supply terminal, and load voltage and current instantaneously resume at their correct steady-state values.