Abstract: An implantable device that includes at least one sealed chamber containing any of a variety of therapeutic or cytotoxic agents is described. The device is implanted into the patient at one or more sited requiring treatment, e.g., at several sites within a tumor. Once the device is implanted in the patient, the chamber retains its contents until a bioresorbable element of the chamber (e.g., a seal) dissolves, creating an opening through which the agent migrates out of the chamber and enters the body. The bioresorbable element can be simply a plug seal in a plastic or metal chamber. Alternatively, all or part of the chamber itself can be formed of a bioresorbable material. The agent can be chemical or biological.

Abstract: An implantable unit for stimulating an internal body organ in which there is a power supply portion for having power induced therein from a source external of the body and electrodes adapted to be attached to a muscular organ such as a bladder or the like, said unit having an energy storage device, such as a capacitor, connected to the electrodes under the control of a transistor which is normally maintained non-conductive as a result of the voltage drop across an impedance connected to the power supply so that each time that the power supply is interrupted, the transistor becomes conductive to discharge the energy storage device through the electrodes and apply a stimulating voltage to the organ. The transmitter source external of the body is designed to periodically interrupt for a short period the voltage transmitted thereby so that the voltage produced by the power supply of the implantable unit is thus periodically interrupted.