Patents by Inventor Eugene L. Giroux

Eugene L. Giroux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidase inhibitors
    Patent number: 6130315
    Abstract: This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: October 10, 2000
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: H. Michael Kolb, Joseph P. Burkhart, Michael J. Jung, Fritz E. Gerhart, deceased, Eugene L. Giroux, Bernhard Neises, Daniel G. Schirlin
  • Peptidase inhibitors
    Patent number: 5849866
    Abstract: This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 15, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: H. Michael Kolb, Joseph P. Burkhart, Michel J. Jung, Fritz E. Gerhart, deceased, Eugene L. Giroux, Bernhard Neises, Daniel G. Schirlin
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5527795
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: June 18, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Peptidase inhibitors
    Patent number: 5496927
    Abstract: This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: March 5, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: H. Michael Kolb, Joseph P. Burkhart, Michel J. Jung, Fritz E. Gerhart, deceased, Eugene L. Giroux, Bernhard Neises, Daniel G. Schirlin
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5491143
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: February 13, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5430145
    Abstract: The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: July 4, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Alan M. Warshawsky, Douglas W. Beight, Shujaath Mehdi, Eugene L. Giroux, Timothy P. Burkholder, Edward D. Daugs, John F. French
  • Snake bite therapy
    Patent number: 4439443
    Abstract: A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is O, S or NH; R is H, a straight or branched chain lower alkyl group of from 1 to 4 carbon atoms, hydroxy, a straight or branched chain lower alkoxy group of from 1 to 4 carbon atoms, fluoro, chloro, bromo, iodo or trifluoromethyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: March 27, 1984
    Assignee: Richardson-Merrell Inc.
    Inventor: Eugene L. Giroux
  • Snake bite therapy
    Patent number: 4347255
    Abstract: A method of reducing local hemorrhage and tissue necrosis resulting from the bite or sting of a venomous animal whereby an envenomated mammal is treated with a compound of the formula: ##STR1## or a corresponding disulfide wherein n is 1, 2 or 3; Z is O, S or NH; R is H, a straight or branched chain lower alkyl group of from 1 to 4 carbon atoms, hydroxy, a straight or branched chain lower alkoxy group of from 1 to 4 carbon atoms, fluoro, chloro, bromo, iodo or trifluoromethyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 7, 1981
    Date of Patent: August 31, 1982
    Assignee: Richardson-Merrell Inc.
    Inventor: Eugene L. Giroux
  • Use of .alpha.,.alpha.'-dithiobis-(.beta.-arylacrylic acid) derivatives in the treatment of hypertension
    Patent number: 4226882
    Abstract: This invention relates to a novel method for treating hypertension, which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S or NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2, or 3.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: October 7, 1980
    Assignee: Merrell Toraude et Compagnie
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Use of .alpha.,.alpha.'-dithiobis(.beta.-arylacrylic acid) derivatives in heavy metal poisoning
    Patent number: 4210665
    Abstract: This invention relates to a novel method for combatting heavy metal poisoning which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: July 1, 1980
    Assignee: Merrell Toraude et Compagnie
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Use of .alpha.,.alpha.'-dithiobis(.beta.-arylacrylic acid) derivatives to enhance zinc serum and tissue concentrations
    Patent number: 4210664
    Abstract: This invention relates to a novel method for enhancing zinc serum and tissue concentrations which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: July 1, 1980
    Assignee: Merrell Toraude et Compagnie
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Use of .alpha.-mercapto-.beta.-arylacrylic acid derivatives in heavy metal poisoning
    Patent number: 4169149
    Abstract: This invention relates to a novel method for combatting poisoning resulting from heavy metals which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: September 25, 1979
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Method of treating hypertension
    Patent number: 4130653
    Abstract: This invention relates to a novel method for the treatment of hypertension which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: December 19, 1978
    Assignee: Merrell Toraude et Compagnie
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Enhancing zinc serum and tissue levels
    Patent number: 4124718
    Abstract: Zinc serum and tissue levels are enhanced by therapeutic administration of certain .alpha.-mercapto-.beta.-aryl acrylic acids.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: November 7, 1978
    Assignee: Merrell Toraude et Compagnie
    Inventors: Eugene L. Giroux, Nellikunja J. Prakash, Paul J. Schechter
  • Method of controlling obesity with purified active principle of fruit of Synsepalum dulcificum
    Patent number: 3995031
    Abstract: A process for the purification of the active principle of the fruit of the plant Synsepalum dulcificum is disclosed. The process includes contacting the fruit with a suspension of polyvinyl pyrrolidone, followed by adsorption of the active principle by means of chromatography procedures. By following the process in accordance with the present invention, proteases and tannins are substantially completely eliminated from the final product. The active principle of this fruit, when prepared in accordance with the present invention, has been found to be particularly useful in controlling obesity in human beings.
    Type: Grant
    Filed: July 23, 1974
    Date of Patent: November 30, 1976
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Robert I. Henkin, Eugene L. Giroux