Patents by Inventor Eugene V. Koonin

Eugene V. Koonin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING CLASS 2 CRISPR-CAS SYSTEMS
    Publication number: 20210166783
    Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 3, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH
    Inventors: Sergey SHMAKOV, Kira S. MAKAROVA, Yuri I. WOLF, Aaron SMARGON, Neena PYZOCHA, David COX, Winston YAN, David SCOTT, Konstantin SEVERINOV, Feng ZHANG, Eugene V. KOONIN
  • Regulation of target protein activity through modifier proteins
    Patent number: 7291494
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: November 6, 2007
    Assignees: California Institute of Technology, National Institutes of Health
    Inventors: Gregory Cope, Rati Verma, Lakshminarayanan Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio
  • Regulation of target protein activity through modifier proteins
    Publication number: 20030166243
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g. isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: January 14, 2002
    Publication date: September 4, 2003
    Inventors: Gregory Cope, Rati Verma, L. Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio