Patents by Inventor Eun Byul Kwon

Eun Byul Kwon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9861712
    Abstract: Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: January 9, 2018
    Assignee: Hanwha Chemical Corporation
    Inventors: Taeg Hwan Hyeon, Byung Hyo Kim, No Hyun Lee, Eung Gyu Kim, Bong Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Patent number: 9771275
    Abstract: The present invention relates to a method for preparing uniform metal oxide nanoparticles. According to the preparation method of the present invention, it is possible to maintain the temperature and pressure inside the reactor in a stable and constant manner by removing water generated in the reaction step for forming metal oxide nanoparticles. Thus, the uniformity of nanoparticles formed is increased, and the reproducibility between batches can be increased even in a repeated process and and a large-scale reaction. Therefore, the preparation method of the present invention can be used to synthesize uniform nanoparticles reproducibly in large quantities.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 26, 2017
    Assignee: HANWHA CHEMICAL CORPORATION
    Inventors: Ju Young Park, Eung Gyu Kim, Wan Jae Myeong, Bong Sik Jeon, Eun Byul Kwon
  • Patent number: 9757482
    Abstract: Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5?100*D?(IO)/C?(IO)??[Relation 1] 2.5?100*D?(Cap)/C?(Cap)??[Relation 2] 0.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: September 12, 2017
    Assignee: HANWHA CHEMICAL CORPORATION
    Inventors: Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Publication number: 20160303163
    Abstract: Provided are a pharmaceutical composition including iron oxide nanoparticles for preventing or treating iron deficiency and iron deficiency anemia accompanied thereby, and a preparation method thereof.
    Type: Application
    Filed: December 23, 2014
    Publication date: October 20, 2016
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Bong Sik JEON, Eun Byul KWON, Eung Gyu KIM, Wan Jae MYEONG, Ju Young PARK
  • Publication number: 20160297687
    Abstract: The present invention relates to a method for preparing uniform metal oxide nanoparticles. According to the preparation method of the present invention, it is possible to maintain the temperature and pressure inside the reactor in a stable and constant manner by removing water generated in the reaction step for forming metal oxide nanoparticles. Thus, the uniformity of nanoparticles formed is increased, and the reproducibility between batches can be increased even in a repeated process and and a large-scale reaction. Therefore, the preparation method of the present invention can be used to synthesize uniform nanoparticles reproducibly in large quantities.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 13, 2016
    Inventors: Ju Young PARK, Eung Gyu KIM, Wan Jae MYEONG, Bong Sik JEON, Eun Byul KWON
  • Patent number: 9457104
    Abstract: Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 4, 2016
    Assignee: HANWHA CHEMICAL CORPORATION
    Inventors: Eung Gyu Kim, Bong-Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Patent number: 9028875
    Abstract: Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: May 12, 2015
    Assignee: Hanwha Chemical Corporation
    Inventors: Eun Byul Kwon, Bong-Sik Jeon, Eung Gyu Kim, Ju Young Park, Wan Jae Myeong
  • Patent number: 8906346
    Abstract: Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: December 9, 2014
    Assignee: Hanwha Chemical Corporation
    Inventors: Ju Young Park, Wan Jae Myeong, Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Taeghwan Hyeon, Daishun Ling
  • Publication number: 20140328768
    Abstract: Provided is an iron oxide nanocapsule which has extremely excellent water dispersibility, which is very stable in the body and which has very excellent MRI contrast ability, a method of manufacturing the same, and an MRI contrast agent using the same. The method of manufacturing the iron oxide nanocapsule includes the steps of: thermally decomposing an iron complex to prepare hydrophobic ligand-bonded iron oxide nanoparticles; and encapsulating the hydrophobic ligand-bonded iron oxide nanoparticles by a carboxymethyldextrandodecylamine conjugate encapsulation material or a dextran-linoleic acid conjugate encapsulation material to form an iron oxide nanocapsule.
    Type: Application
    Filed: August 31, 2011
    Publication date: November 6, 2014
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Eun Byul Kwon, Bong Sik Jeon, Eung Gyu Kim, Ju Young Park, Wan Jae Myeong
  • Publication number: 20140161734
    Abstract: Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.
    Type: Application
    Filed: August 3, 2012
    Publication date: June 12, 2014
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Eung Gyu Kim, Bong-Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Publication number: 20140023594
    Abstract: Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.
    Type: Application
    Filed: June 20, 2012
    Publication date: January 23, 2014
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Ju Young Park, Wan Jae Myeong, Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Taeghwan Hyeon, Daishun Ling
  • Publication number: 20130164222
    Abstract: Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.
    Type: Application
    Filed: August 5, 2011
    Publication date: June 27, 2013
    Applicant: Hanwha Chemical Corporation
    Inventors: Taeg Hwan Hyeon, Byung Hyo Kim, No Hyun Lee, Eung Gyu Kim, Bong Sik Jeon, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Publication number: 20130164223
    Abstract: Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5?100*D?(IO)/C ?(IO)??[Relation 1] 2.5?100*D?(Cap)/C ?(Cap)??[Relation 2] 0.
    Type: Application
    Filed: August 30, 2011
    Publication date: June 27, 2013
    Applicant: HANWHA CHEMICAL CORPORATION
    Inventors: Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong