Abstract: The present invention relates to a Trolox-peptide conjugate having a structure in which Trolox and a peptide are chemically bonded. The Trolox-peptide conjugate not only very effectively inhibits the activity of 5?-reductase, but also inhibits the death of papilla cells and keratinocytes, promotes the growth thereof, and has antioxidative effects, and thus can remarkably promote hair formation while avoiding or preventing hair loss.

Abstract: A peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, 3, or 4, a pharmaceutical composition for preventing or treating skin disease including the peptide, a cosmetic composition for skin condition improvement including the peptide, a food composition for skin condition improvement including the peptide, a method of preventing or treating skin disease using the peptide, and a use of the peptide in preventing or treating skin disease or improving skin condition are described.

Abstract: Provided are a peptide having skin-whitening activity and use thereof, and a peptide consisting of an amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, a skin-whitening composition including the peptide, a cosmetic composition including the skin-whitening composition, and a pharmaceutical composition for preventing or treating a melanin hyperpigmentation disease, the pharmaceutical composition including the skin-whitening composition.

Abstract: An electrostatic cleaning device includes: a static electricity generator configured to generate static electricity; a handle part connected to one side of the static electricity generator; and a cleaning tool adapted to be assembled to and disassembled from the static electricity generator. The static electricity generator includes a first electrified body part configured as a donut-shaped case and configured to deliver a negative charge to the cleaning tool; a belt rotatably installed in an inner space of the first electrified body part and configured to transfer the negative charge; and a second electrified body part configured to supply the negative charge to the belt.

Abstract: The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.

Abstract: Provided are a peptide with a cytoprotective effect against environmental pollutants and a use thereof. The peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3 directly binds to 2,3,7,8-tetrachlorodibenzo-p-dioxin (hereinafter, referred to as TCDD), known as being the most toxic among the class of dioxins, to prevent dermal penetration and the activation mechanism of AhR by TCDD and polycyclic aromatic hydrocarbons contained in fine dust. Such a direct cytoprotective effect against environmental pollutants is distinguished from preexisting methods that are configured to indirectly block opportunities to contact these materials or to reduce toxicity through barrier reinforcement.

Abstract: A method for processing data in the ETL process according to an embodiment of the present disclosure includes retrieving data having a preset size from a database, storing the retrieved data having the preset size as raw data, performing a type casting operation of converting a type of the data to store the raw data in a target storage, loading the raw data converted via the type casting operation into a memory and when a size of the raw data loaded into the memory reaches a reference value, batch-processing the raw data loaded into the memory and storing the raw data in the target storage.

Abstract: The present invention provides a peptide exhibiting melanogenesis promoting activity. A peptide according to the present invention increases the activity and expression of tyrosinase and the expression of factors involved in melanogenesis, thereby exhibiting an outstanding effect on melanogenesis. The peptide of the present invention can be used for the prevention, alleviation, and treatment of hypomelanosis. The outstanding activity and stability stated above allow the peptide of the present invention to be very favorably applied to medicines, quasi-medicines, and cosmetics.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: Embodiments herein describe an integrated circuit that includes a NoC with at least two levels of switching: a sparse network and a non-blocking network. In one embodiment, the non-blocking network is a localized interconnect that provides an interface between the sparse network in the NoC and a memory system that requires additional bandwidth such as HBM2/3 or DDR5. Hardware elements connected to the NoC that do not need the additional benefits provided by the non-blocking network can connect solely to the sparse network. In this manner, the NoC provides a sparse network (which has a lower density of switching elements) for providing communication between lower bandwidth hardware elements and a localized non-blocking network for facilitating communication between the sparse network and higher bandwidth hardware elements.

Abstract: Provided are a peptide having skin-whitening activity and use thereof, and a peptide composed of an amino acid sequence of SEQ ID NO: 1, a skin-whitening cosmetic composition including the peptide, a pharmaceutical composition for preventing or treating a hyperpigmentation disease, the pharmaceutical composition including the peptide, and a method of whitening the skin using the same, or a method of preventing, improving or treating a hyperpigmentation disease using the same.

Abstract: The present invention relates to: a novel peptide having activity of preventing skin damage caused by pollutants, and skin anti-aging and wrinkle alleviation activities; and a use of the peptide, which is related to the prevention or treatment of diseases caused by pollutants or to the improvement of skin anti-aging. Particularly, the novel peptide of the present invention inhibits the inflow, into skin cells, of pollutants such as dioxin, particulate matter, and cigarette smoke, and regulates the expression of a skin aging-related gene, and thus may be effectively used as an active ingredient of a pharmaceutical composition for preventing or treating cancer, skin diseases, and lung diseases, which are caused by pollutants, or skin aging-related diseases, or as an active ingredient of a cosmetic composition for preventing skin damage caused by pollutants or for a skin anti-aging effect.

Abstract: A compound comprising a structure in which isotretinoin is linked to a peptide via a covalent bond and an antibiotic, anti-inflammatory, or anti-oxidative pharmaceutical or cosmetic composition comprising the same. A compound having a structure in which isotretinoin is linked to a peptide via a covalent bond according to the present invention exhibits excellent physiological activity such as antibiotic, anti-inflammatory, or anti-oxidative actions, as well as having outstanding properties, such as solubility in water, etc., and thus can find useful applications in various fields including medicines, cosmetics, etc.

Abstract: Provided are a peptide having an activity of promoting hair generation and use thereof. In particular, provided are a peptide consisting of an amino acid sequence of SEQ ID NO: 1, a composition including the peptide for improving hair loss or promoting hair generation, and a pharmaceutical composition including the peptide for preventing or treating hair loss.

Abstract: Provided are a peptide having an activity of promoting hair generation and use thereof. In particular, provided are a peptide consisting of an amino acid sequence of SEQ ID NO: 1, a composition including the peptide for improving hair loss or promoting hair generation, and a pharmaceutical composition including the peptide for preventing or treating hair loss.

Abstract: A facial beauty device according to an embodiment may comprise: a face body; a seating member coupled to the face body; and a support part disposed on one side of the face body. The face body may comprise: a first face body; a second face body; and a circuit board disposed between the first face body and the second face body. The circuit board may include a predetermined stimulation providing part disposed thereon. The second face body may include a mask sheet disposed at the inner side thereof.

Abstract: Provided are a peptide having an activity of improving skin condition and use thereof. In particularly, provided are a peptide consisting of an amino acid sequence of SEQ ID NO: 1, a cosmetic composition including the peptide for improving skin condition, and a pharmaceutical composition including the peptide for preventing or treating an inflammatory skin disease.

Abstract: The present invention is for providing a skin care apparatus which provides skin care focusing on eye rims, forehead and the like. The skin care apparatus comprises: a main body; and a mounting body for mounting the main body on a user's face. A sheet accommodation part for accommodating a sheet is formed on the main body. The main body comprises at least one first area coming into contact with a sheet accommodated in the sheet accommodation part and a second area between the edge of the main body and the first area. The thickness of the first area can be smaller than the thickness of the second area.

Abstract: The present invention relates to a co-crystalline form of efinaconazole and a pharmaceutically acceptable coformer forming a co-crystalline phase. The present invention also relates to a method for preparing the co-crystalline form. The co-crystallization product of efinaconazole according to the present invention meets all requirements for use as an active ingredient of a pharmaceutical composition and is highly stable to heat and other one or more other ingredients of the composition. Therefore, the co-crystallization product of efinaconazole is suitable for use in the preparation of pharmaceuticals. In addition, the method of the present invention enables the preparation of the co-crystallization product of efinaconazole in a simple and easy manner on a commercial scale.

Abstract: Provided are a peptide having skin-whitening activity and use thereof, and a peptide consisting of an amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, a skin-whitening composition including the peptide, a cosmetic composition including the skin-whitening composition, and a pharmaceutical composition for preventing or treating a melanin hyperpigmentation disease, the pharmaceutical composition including the skin-whitening composition.