Patents by Inventor Eva Kudova

Eva Kudova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3ALPHA, 5BETA-NEUROACTIVE STEROIDS FOR THE TREATMENT OF EPILEPSY AND SEIZURE DISEASES
    Publication number: 20220162257
    Abstract: 3?5?-steroid compounds of general formula I is disclosed. These compounds are useful in the treatment of epilepsy or comorbidities associated with epilepsy or conditions associated with convulsions, such as seizures associated with hypoxia, seizures associated with traumatic brain damage, seizures associated with intoxication, pathological changes caused by hyperexcitation, or in treatment of conditions accompanying epilepsy, such as affective disorders, depression, post-traumatic stress disorder (PTSD) and stress-related diseases, anxiety, schizophrenia and psychotic disorders, related ischemic CNS damage, neurodegenerative changes and disorders, multiple sclerosis. The compounds of general formula I also show age-specific efficacy.
    Type: Application
    Filed: April 2, 2020
    Publication date: May 26, 2022
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., FYZIOLOGICKY USTAV AV CR, V. V. I.
    Inventors: Eva KUDOVA, Hana CHODOUNSKA, Pavel MARES, Karel VALES
  • STEROIDAL COMPOUNDS FOR TREATMENT OF MENTAL AND NEUROLOGICAL DISORDERS
    Publication number: 20200330484
    Abstract: The present invention provides steroidal compounds for the treatment of mental and neurological disorders by targeted rectification of defects caused by a mutation occurring in the membrane region of a human N-methyl-D-aspartate receptor subunit by potentiation of the effects of the said receptor.
    Type: Application
    Filed: November 26, 2018
    Publication date: October 22, 2020
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., FYZIOLOGICKY USTAV AV CR, V. V. I.
    Inventors: Eva KUDOVA, Ladislav VYKLICKY
  • Amphiphilic compounds with neuroprotective properties
    Patent number: 10017535
    Abstract: Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing compound.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: July 10, 2018
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., FYZIOLOGICKY USTAV AV CR, V.V.I.
    Inventors: Eva Kudova, Hana Chodounska, Vojtech Kapras, Ladislav Vyklicky, Karel Vales, Ullrich Jahn
  • AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES
    Publication number: 20170240588
    Abstract: Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing compound.
    Type: Application
    Filed: August 25, 2015
    Publication date: August 24, 2017
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, v.v.i., FYZIOLOGICKY USTAV AV CR, v.v.i.
    Inventors: Eva KUDOVA, Hana CHODOUNSKA, Vojtech KAPRAS, Ladislav VYKLICKY, Karel VALES, Ullrich JAHN
  • Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
    Patent number: 9388210
    Abstract: The present disclosure is generally directed to neuroactive 17(20)-Z-vinylcyano-substituted compound of Formula (I) and (II), as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: July 12, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Douglas Covey, Eva Kudova