Abstract: Various embodiments of the present disclosure disclose methods and systems for heat exchange in an opto-fluidic instrument. The opto-fluidic instrument includes a sample interface module (SIM), an illumination module, a camera module, and a reagent deck. A coolant from a coolant reservoir is directed into one or more of the modules so that heat exchange occurs at each module with the coolant. The heated coolant from the one or more modules flows to a radiator for cooling, for example, with fans flowing ambient air over the radiator, before the cooled coolant is returned to the coolant reservoir for subsequent use in cooling the modules.

Abstract: An imaging system includes an optical mounting plate having an aperture disposed between a first portion and a second portion, an imaging sensor disposed on the first portion, an objective lens disposed on the second portion, and an illumination assembly arranged within the aperture and disposed between the imaging sensor and the objective lens. The imaging system includes a heat sink coupled to the illumination assembly and configured to transfer heat away from light sources of the illumination assembly via a working fluid that flows through the heat sink.

Abstract: An imaging system includes an optical mounting plate having an aperture disposed between a first portion and a second portion, an imaging sensor disposed on the first portion, an objective lens disposed on the second portion, and an illumination assembly arranged within the aperture and disposed between the imaging sensor and the objective lens. The imaging system includes a heat sink coupled to the illumination assembly and configured to transfer heat away from light sources of the illumination assembly via a working fluid that flows through the heat sink.

Abstract: Various embodiments of the present disclosure disclose mitigating internal and external vibrational disturbances in opto-fluidic instrument. In various embodiments, the resonance frequency ranges and/or the vibrational frequency ranges of various modules and components of the opto-fluidic instrument may be selected to avoid resonances from occurring in the opto-fluidic instrument, thereby mitigating vibrations from internal and external sources that may distort the imaging of samples in the opto-fluidic instrument.

Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: According to an aspect, an electrochemical cell may include a vessel, at least two instances of an anode assembly, at least two instances of an oxygen evolution electrode (OEE), and a gas diffusion electrode (GDE). In the vessel, the GDE may be disposed between mirrored arrangements of the at least two instances of the OEE and the at least two instances of the anode assembly.

Abstract: A system for and a method of measuring ultrasonic wave velocities in a subterranean core specimen is provided. Ultrasonic wave velocities are measured from the side surfaces (faces) of a polygonal-shaped core specimen having at least ten sides or faces. Stress is introduced to the core specimen by hydraulic rams associated with each set of opposing sides. As stress is applied, ultrasonic waves are introduced to at least one side of the set of opposing sides and the wave transmitted through the core specimen is measured. Subsequently, the wave velocity for the ultrasonic wave can be calculated based on the measurements taken. Also, elastic properties associated with the core specimen can be calculated.

Abstract: A system for and a method of measuring ultrasonic wave velocities in a subterranean core specimen is provided. Ultrasonic wave velocities are measured from the side surfaces (faces) of a polygonal-shaped core specimen having at least ten sides or faces. Stress is introduced to the core specimen by hydraulic rams associated with each set of opposing sides. As stress is applied, ultrasonic waves are introduced to at least one side of the set of opposing sides and the wave transmitted through the core specimen is measured. Subsequently, the wave velocity for the ultrasonic wave can be calculated based on the measurements taken. Also, elastic properties associated with the core specimen can be calculated.

Abstract: Payroll requirements are compiled from a plurality of jurisdictions. A plurality of payroll codes are cataloged that are required in one of the plurality of jurisdictions. A user representation includes the plurality of payroll codes. An implementation representation of calculating pay is formed. The implementation representation is based on the user representation and includes a plurality of elements. A specification for each element of the implementation representation is created.

Abstract: A low temperature method of producing beryllium chloride dietherate through the addition of hydrogen chloride gas to a mixture of beryllium metal in ether in a reaction vessel is described. A reflux condenser provides an exit for hydrogen produced form the reaction. A distillation condenser later replaces the reflux condenser for purifying the resultant product.